Curcumin 관련 Ulcerative Colitis (UC)
BMulticenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
결론
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
vs: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
효과: None
None
대상 집단: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
vs: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
효과: None
None
대상 집단: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
vs: Various comparators
Outcome: Multiple health outcomes
효과: None
None
대상 집단: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
vs: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
효과: None
None
대상 집단: DSS-induced UC murine model
Key Statistics
5
연구
400
참여자
↑
Positive
B
등급
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 인용
Frontiers in immunology
2025
20 인용
Naunyn-Schmiedeberg's archives of …
2025
14 인용
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 인용
BioFactors (Oxford, England)
2025
9 인용
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 인용
European journal of …
2025
7 인용
Explore (New York, …
2025
5 인용
Journal of agricultural …
2025
3 인용
Materials today. Bio
2025
3 인용
Frontiers in nutrition
2025
2 인용
Frontiers in pharmacology
2025
1 인용
Cellular and molecular …
2025
Nutrients
2025
International journal of …
2025
Clinical gastroenterology and …
2024
52 인용
Food research international …
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44 인용
Advanced materials (Deerfield …
2024
37 인용
Journal of pharmaceutical …
2024
29 인용
International journal of …
2024
27 인용
Nutrients
2024
23 인용
ACS omega
2024
16 인용
Frontiers in pediatrics
2024
4 인용
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 인용
World journal of …
2024
Frontiers in endocrinology
2023
253 인용
Metabolites
2023
134 인용
Advanced science (Weinheim, …
2023
90 인용
Journal of nanobiotechnology
2023
63 인용
Pharmaceuticals (Basel, Switzerland)
2023
18 인용
Toxicology mechanisms and …
2023
5 인용
Journal of nanobiotechnology
2022
206 인용
International journal of …
2022
142 인용
The American journal …
2022
86 인용
Frontiers in immunology
2022
68 인용
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
Journal of ethnopharmacology
2022
39 인용
American family physician
2022
38 인용
Nutrients
2022
19 인용
Turkish journal of …
2022
3 인용
Advances in experimental …
2021
87 인용
Molecules (Basel, Switzerland)
2021
85 인용
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 인용
European journal of …
2021
40 인용
Complementary therapies in …
2021
30 인용
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 인용
Clinical gastroenterology and …
2020
49 인용
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 인용
Nutrients
2020
30 인용
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 인용
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
2020
25 인용
Therapeutic advances in …
2020
21 인용
Medicine
2020
4 인용
International journal of …
2019
137 인용
Nutrients
2019
71 인용
Critical reviews in …
2019
48 인용
Journal of medicinal …
2019
17 인용
Immunopharmacology and immunotoxicology
2018
96 인용
Gastroenterology clinics of …
2018
67 인용
Nutrients
2018
46 인용
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 인용
Medical principles and …
2017
45 인용
Acta medica Indonesiana
2017
24 인용
The Medical clinics …
2017
9 인용
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
41 인용
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 인용
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 인용
Annals of gastroenterology
2015
135 인용
Molecules (Basel, Switzerland)
2014
122 인용
World journal of …
2014
23 인용
The AAPS journal
2013
1866 인용
Alimentary pharmacology & …
2013
128 인용
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 인용
Food & function
2012
151 인용
Revista de gastroenterologia …
2008
2 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
상한량: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
권장 복용 시간: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
보고된 부작용
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
알려진 상호작용
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
일일 최대 섭취 허용량: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Ulcerative Colitis (UC)
Curcumin 다른 건강 상태에 대한 근거
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