CurcuminCurcumin
herb
Curcumin
Curcumin
别名: Turmeric Extract, Curcuma longa, Curcuminoids, Theracurmin, BCM-95, Meriva
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About
姜黄素是姜黄中的主要生物活性多酚，在胃肠道中具有强效的抗炎特性。它在肠粘膜中抑制NF-κB和COX-2炎症级联。多中心CUBE试验证明，姜黄素与美沙拉明一起可能有助于维持溃疡性结肠炎的缓解，降低复发率。姜黄素还支持粘膜愈合，可能有助于调节肠道微生物组。
How It Works
Inhibits NF-kB and COX-2 inflammatory cascades in intestinal mucosa reducing pro-inflammatory cytokine production; enhances mucosal healing through TGF-beta signaling; modulates gut microbiome increasing Bifidobacteria populations; reduces intestinal oxidative stress via Nrf2 pathway activation.
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| Ulcerative Colitis (UC) | B | 5 | 400 | 查看 → |
| Crohn's Disease | C | 3 | 200 | 查看 → |
| Irritable Bowel Syndrome (IBS) | C | 2 | 200 | 查看 → |
Side Effects
- GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- Yellow staining of skin/teeth with topical/oral contact
- Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- Iron chelation (may reduce iron absorption at very high doses)
Drug & Supplement Interactions
- Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- Iron supplements (curcumin may chelate iron; space dosing)
- Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
请务必告知您的医疗保健提供者您正在服用的所有补充剂。
Related Ingredients
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