Aloe Vera (Inner Leaf Gel) 用于 溃疡性结肠炎（UC）
D 研究 目前仅存在初步研究（实验室研究、病例报告）。Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.
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D
结论
Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.
Key Study Findings
Review
Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of natural therapies for IBD
In Vitro
1.0 weeks
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Dose: 272 µg/
vs: vehicle
Outcome: Ulcerative colitis severity
效果: None
None
研究人群: Mice (DSS-induced colitis model)
Controlled Clinical Trial
n=36
2 weeks
Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.
Dose: 20, 40, or 60 mg/kg b.wt.
vs: Dexamethasone 1 mg/kg and normal saline
Outcome: Clinical activity index, histological alterations, DNA, NO
效果: None
None
研究人群: Adult male Wistar rats with acetic acid-induced UC
Review
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Ulcerative colitis patients using CAM
Other
Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Controlled Clinical Trial
Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.
Dose: None
vs: Control without aloe vera
Outcome: Anti-inflammatory, antioxidant, wound healing
效果: None
None
研究人群: Animal/cell wound healing models
Key Statistics
1
研究数量
44
受试者
↑
Positive
D
等级
Referenced Papers
Current pharmaceutical biotechnology
2025
1 次引用
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Other
Current issues in …
2023
3 次引用
Phytomedicine : international …
2022
22 次引用
Toxicology reports
2022
9 次引用
Turkish journal of …
2022
3 次引用
Journal of ethnopharmacology
2021
45 次引用
Evidence-based complementary and …
2021
36 次引用
Middle East journal …
2020
26 次引用
Clinical nutrition research
2020
23 次引用
Therapeutic advances in …
2020
21 次引用
Medical science monitor …
2019
14 次引用
Annals of gastroenterology
2016
41 次引用
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 次引用
Annals of gastroenterology
2015
135 次引用
World journal of …
2014
23 次引用
Alimentary pharmacology & …
2013
128 次引用
Saudi journal of …
2012
138 次引用
Alimentary pharmacology & …
2006
181 次引用
Alimentary pharmacology & …
2004
264 次引用
Health news (Waltham, …
2004
1 次引用
BioFactors (Oxford, England)
2003
38 次引用
The European journal …
1998
62 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
- ibssupport:
- 100 mL twice daily for 1-3 months
- constipation:
- 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)
上限： No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| 272 µg/ | 1.0 weeks | Positive | -- |
| 20, 40, or 60 mg/kg b.wt. | 2 weeks | Positive | 36 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 2 g | 3 weeks | Positive | -- |
最佳服用时间： Before meals; aloe latex should only be used short-term for constipation
Safety & Side Effects
已报告的副作用
- ⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
- ⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
- ⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
- ⚠ Allergic skin reactions in sensitive individuals
已知相互作用
- ● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
- ● Diuretics (additive potassium loss with aloe latex)
- ● Diabetes medications (aloe may lower blood sugar; monitor glucose)
- ● Stimulant laxatives (additive laxative effect; avoid combining)
- ● Anticoagulants (theoretical interaction due to platelet effects)
可耐受最高摄入量： No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Aloe Vera (Inner Leaf Gel) help with 溃疡性结肠炎（UC）?
Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support 溃疡性结肠炎（UC） management. Our evidence grade is D (Very Early Research).
How much Aloe Vera (Inner Leaf Gel) should I take for 溃疡性结肠炎（UC）?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and 溃疡性结肠炎（UC）?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 溃疡性结肠炎（UC）
Aloe Vera (Inner Leaf Gel) 用于其他健康状况
References
- [1] Monika Joshi et al.. Curr Pharm Biotechnol. 2025. Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease. doi:10.2174/0113892010293150240415143650 PubMed
- [2] Do Yeong Kweon et al.. Curr Issues Mol Biol. 2023. Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium. doi:10.3390/cimb45020096 PubMed
- [3] Hui Jiang et al.. Phytomedicine. 2022. Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. doi:10.1016/j.phymed.2022.154403 PubMed
- [4] W O Babalola et al.. Toxicol Rep. 2022. Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats. doi:10.1016/j.toxrep.2022.03.048 PubMed
- [5] Alaattin Şen. Turk J Med Sci. 2022. Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. doi:10.55730/1300-0144.5482 PubMed
- [6] Gaofeng Shi et al.. J Ethnopharmacol. 2021. Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier. doi:10.1016/j.jep.2021.114108 PubMed
- [7] Mahvash Alizade Naini et al.. Evid Based Complement Alternat Med. 2021. Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats. doi:10.1155/2021/9945244 PubMed
- [8] Negar Hassanshahi et al.. Middle East J Dig Dis. 2020. The Healing Effect of Aloe Vera Gel on Acetic Acid-Induced Ulcerative Colitis in Rat. doi:10.34172/mejdd.2020.177 PubMed
- [9] Gholamreza Bahrami et al.. Clin Nutr Res. 2020. Protective and Therapeutic Effects of Aloe Vera Gel on Ulcerative Colitis Induced by Acetic Acid in Rats. doi:10.7762/cnr.2020.9.3.223 PubMed
- [10] Sherman Picardo et al.. Therap Adv Gastroenterol. 2020. Complementary and alternative medications in the management of inflammatory bowel disease. doi:10.1177/1756284820927550 PubMed
- [11] Ling Gai et al.. Med Sci Monit. 2019. Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway. doi:10.12659/MSM.918935 PubMed
- [12] John K Triantafillidis et al.. Ann Gastroenterol. 2016. Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies. doi:10.20524/aog.2016.0059 PubMed
- [13] Alyssa Parian et al.. Curr Pharm Des. 2016. Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis. doi:10.2174/1381612822666151112145033 PubMed
- [14] Aikaterini Triantafyllidi et al.. Ann Gastroenterol. 2015. Herbal and plant therapy in patients with inflammatory bowel disease. PubMed
- [15] Ping Wan et al.. World J Gastroenterol. 2014. Advances in treatment of ulcerative colitis with herbs: from bench to bedside. doi:10.3748/wjg.v20.i39.14099 PubMed
- [16] S C Ng et al.. Aliment Pharmacol Ther. 2013. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. doi:10.1111/apt.12464 PubMed
- [17] Fei Ke et al.. Saudi J Gastroenterol. 2012. Herbal medicine in the treatment of ulcerative colitis. doi:10.4103/1319-3767.91726 PubMed
- [18] L Langmead et al.. Aliment Pharmacol Ther. 2006. Review article: complementary and alternative therapies for inflammatory bowel disease. doi:10.1111/j.1365-2036.2006.02761.x PubMed
- [19] L Langmead et al.. Aliment Pharmacol Ther. 2004. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. doi:10.1111/j.1365-2036.2004.01902.x PubMed
- [20] . Health News. 2004. Aloe vera helps ulcerative colitis. PubMed
- [21] Ludmila Korkina et al.. Biofactors. 2003. The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative … doi:10.1002/biof.5520180228 PubMed
- [22] M Robinson. Eur J Surg Suppl. 1998. Medical therapy of inflammatory bowel disease for the 21st century. doi:10.1080/11024159850191517 PubMed
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