Curcumin لـ Ulcerative Colitis (UC)
BMulticenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
الخلاصة
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
مقابل: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
التأثير: None
None
المجتمع المدروس: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
مقابل: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
التأثير: None
None
المجتمع المدروس: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
مقابل: Various comparators
Outcome: Multiple health outcomes
التأثير: None
None
المجتمع المدروس: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
مقابل: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
التأثير: None
None
المجتمع المدروس: DSS-induced UC murine model
Key Statistics
5
الدراسات
400
المشاركون
↑
Positive
B
التقييم
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 اقتباسات
Frontiers in immunology
2025
20 اقتباسات
Naunyn-Schmiedeberg's archives of …
2025
14 اقتباسات
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 اقتباسات
BioFactors (Oxford, England)
2025
9 اقتباسات
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 اقتباسات
European journal of …
2025
7 اقتباسات
Explore (New York, …
2025
5 اقتباسات
Journal of agricultural …
2025
3 اقتباسات
Materials today. Bio
2025
3 اقتباسات
Frontiers in nutrition
2025
2 اقتباسات
Frontiers in pharmacology
2025
1 اقتباسات
Cellular and molecular …
2025
Nutrients
2025
International journal of …
2025
Clinical gastroenterology and …
2024
52 اقتباسات
Food research international …
2024
44 اقتباسات
Advanced materials (Deerfield …
2024
37 اقتباسات
Journal of pharmaceutical …
2024
29 اقتباسات
International journal of …
2024
27 اقتباسات
Nutrients
2024
23 اقتباسات
ACS omega
2024
16 اقتباسات
Frontiers in pediatrics
2024
4 اقتباسات
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 اقتباسات
World journal of …
2024
Frontiers in endocrinology
2023
253 اقتباسات
Metabolites
2023
134 اقتباسات
Advanced science (Weinheim, …
2023
90 اقتباسات
Journal of nanobiotechnology
2023
63 اقتباسات
Pharmaceuticals (Basel, Switzerland)
2023
18 اقتباسات
Toxicology mechanisms and …
2023
5 اقتباسات
Journal of nanobiotechnology
2022
206 اقتباسات
International journal of …
2022
142 اقتباسات
The American journal …
2022
86 اقتباسات
Frontiers in immunology
2022
68 اقتباسات
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
Meta-Analysis
Journal of ethnopharmacology
2022
39 اقتباسات
American family physician
2022
38 اقتباسات
Nutrients
2022
19 اقتباسات
Turkish journal of …
2022
3 اقتباسات
Advances in experimental …
2021
87 اقتباسات
Molecules (Basel, Switzerland)
2021
85 اقتباسات
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 اقتباسات
European journal of …
2021
40 اقتباسات
Complementary therapies in …
2021
30 اقتباسات
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 اقتباسات
Clinical gastroenterology and …
2020
49 اقتباسات
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 اقتباسات
Nutrients
2020
30 اقتباسات
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 اقتباسات
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
2020
25 اقتباسات
Therapeutic advances in …
2020
21 اقتباسات
Medicine
2020
4 اقتباسات
International journal of …
2019
137 اقتباسات
Nutrients
2019
71 اقتباسات
Critical reviews in …
2019
48 اقتباسات
Journal of medicinal …
2019
17 اقتباسات
Immunopharmacology and immunotoxicology
2018
96 اقتباسات
Gastroenterology clinics of …
2018
67 اقتباسات
Nutrients
2018
46 اقتباسات
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 اقتباسات
Medical principles and …
2017
45 اقتباسات
Acta medica Indonesiana
2017
24 اقتباسات
The Medical clinics …
2017
9 اقتباسات
Ugeskrift for laeger
2017
Annals of gastroenterology
2016
41 اقتباسات
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 اقتباسات
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 اقتباسات
Annals of gastroenterology
2015
135 اقتباسات
Molecules (Basel, Switzerland)
2014
122 اقتباسات
World journal of …
2014
23 اقتباسات
The AAPS journal
2013
1866 اقتباسات
Alimentary pharmacology & …
2013
128 اقتباسات
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 اقتباسات
Food & function
2012
151 اقتباسات
Revista de gastroenterologia …
2008
2 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
الحد الأعلى: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
أفضل وقت للتناول: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
التفاعلات المعروفة
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
الحد الأقصى المسموح به: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Ulcerative Colitis (UC)
Curcumin لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.