Butyrate (Sodium/Calcium Butyrate) 用于 溃疡性结肠炎(UC)
C 证据 来自小型研究的证据有限,但存在一些积极信号。近期一项90天RCT(140名IBD参与者)显示,口服丁酸盐改善了克罗恩病症状和生活质量。早期关于丁酸盐灌肠的研究显示对远端UC有益。
结论
近期一项90天RCT(140名IBD参与者)显示,口服丁酸盐改善了克罗恩病症状和生活质量。早期关于丁酸盐灌肠的研究显示对远端UC有益。
Key Study Findings
研究人群: IBD patients (60 Crohn's disease, 80 ulcerative colitis)
研究人群: UC murine model + UC patient samples
研究人群: Active ulcerative colitis patients
研究人群: RAW264.7 macrophage cell line
研究人群: Caco-2 cells, RAW264.7 macrophages, fecal fermentation
Key Statistics
3
研究数量
390
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 150-600 mg/day sodium or calcium butyrate
- ibdsupport:
- 300-600 mg three times daily (900-1,800 mg/day)
- butyrateenema:
- 100 mM butyrate enema for distal UC (clinical setting only)
上限: No established upper limit for oral supplements; most studies use 600-4,000 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | 140 |
| Lactobacillus reuteri E9 (dose not specified) | -- | Positive | -- |
| None | -- | Positive | -- |
| 600 mg/kg with main meal | 12 weeks | Positive | 36 |
| None | -- | Positive | -- |
| 5 mg/mL | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 212 |
最佳服用时间: With meals; enteric-coated formulations recommended to reach the colon
Safety & Side Effects
已报告的副作用
- ⚠ Unpleasant taste/odor (butyric acid has a strong rancid butter smell)
- ⚠ Mild GI discomfort (nausea, bloating)
- ⚠ Belching with butyric acid odor
- ⚠ Enteric-coated formulations reduce taste issues
已知相互作用
- ● 5-ASA medications (mesalamine) — additive anti-inflammatory effect (potentially beneficial in IBD)
- ● No significant adverse drug interactions known
可耐受最高摄入量: No established upper limit for oral supplements; most studies use 600-4,000 mg/day
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Butyrate (Sodium/Calcium Butyrate) help with 溃疡性结肠炎(UC)?
How much Butyrate (Sodium/Calcium Butyrate) should I take for 溃疡性结肠炎(UC)?
Are there side effects of Butyrate (Sodium/Calcium Butyrate)?
How strong is the evidence for Butyrate (Sodium/Calcium Butyrate) and 溃疡性结肠炎(UC)?
Related Evidence
其他成分用于 溃疡性结肠炎(UC)
Butyrate (Sodium/Calcium Butyrate) 用于其他健康状况
References
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