Curcumin per Ulcerative Colitis (UC)
B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
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B
In sintesi
Multicenter RCT (CUBE trial) showed curcumin (2 g/day) plus mesalamine maintained remission better than mesalamine alone. Reduced relapse rate from 20% to 5% over 12 months.
Key Study Findings
Systematic Review
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Dose: None
vs: placebo or standard therapy
Outcome: ulcerative colitis outcomes (18 outcomes across 7 SR/MAs)
Effetto: None
None
Popolazione: patients with ulcerative colitis
Other
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis.
Dose: None
vs: untreated colitis controls
Outcome: mitigation of colitis symptoms (ROS scavenging, barrier restoration, …
Effetto: None
None
Popolazione: UC animal model and oxidatively stressed colon cells
Review
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin …
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
Systematic Review
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Dose: None
vs: Various comparators
Outcome: Multiple health outcomes
Effetto: None
None
Popolazione: Human subjects across 25 meta-analyses
Review
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
In Vitro
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Dose: None
vs: DSS-induced UC mice
Outcome: UC inflammation via SphK1/NF-kB pathway
Effetto: None
None
Popolazione: DSS-induced UC murine model
Key Statistics
5
Studi
400
Partecipanti
↑
Positive
B
Grado
Referenced Papers
The Complementary and Alternative Roles of Curcumin in Treatment of Ulcerative Colitis: An Umbrella Review.
Systematic Review
Nutrition reviews
2026
ACS nano
2025
29 citazioni
Frontiers in immunology
2025
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Naunyn-Schmiedeberg's archives of …
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14 citazioni
Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses.
Systematic Review
Frontiers in pharmacology
2025
10 citazioni
BioFactors (Oxford, England)
2025
9 citazioni
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 citazioni
European journal of …
2025
7 citazioni
Explore (New York, …
2025
5 citazioni
Journal of agricultural …
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3 citazioni
Materials today. Bio
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3 citazioni
Frontiers in nutrition
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5 citazioni
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206 citazioni
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86 citazioni
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68 citazioni
Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: A systematic review and meta-analysis.
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38 citazioni
Nutrients
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19 citazioni
Turkish journal of …
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3 citazioni
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87 citazioni
Molecules (Basel, Switzerland)
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Meta-Analysis
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Systematic Review
Advances in experimental …
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8 citazioni
Clinical gastroenterology and …
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49 citazioni
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
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48 citazioni
Nutrients
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30 citazioni
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.
Meta-Analysis
Journal of gastroenterology …
2020
30 citazioni
Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis.
Meta-Analysis
Expert review of …
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25 citazioni
Therapeutic advances in …
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21 citazioni
Medicine
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4 citazioni
International journal of …
2019
137 citazioni
Nutrients
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71 citazioni
Critical reviews in …
2019
48 citazioni
Journal of medicinal …
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17 citazioni
Immunopharmacology and immunotoxicology
2018
96 citazioni
Gastroenterology clinics of …
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67 citazioni
Nutrients
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46 citazioni
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Meta-Analysis
The American journal …
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30 citazioni
Medical principles and …
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45 citazioni
Acta medica Indonesiana
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The Medical clinics …
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9 citazioni
Ugeskrift for laeger
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Annals of gastroenterology
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Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
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32 citazioni
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 citazioni
Annals of gastroenterology
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135 citazioni
Molecules (Basel, Switzerland)
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122 citazioni
World journal of …
2014
23 citazioni
The AAPS journal
2013
1866 citazioni
Alimentary pharmacology & …
2013
128 citazioni
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 citazioni
Food & function
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151 citazioni
Revista de gastroenterologia …
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2 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
Limite massimo: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Varying dosages | -- | Positive | -- |
| None | -- | Positive | -- |
Momento migliore per l'assunzione: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
Interazioni note
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
Livello di assunzione massimo tollerabile: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Curcumin help with Ulcerative Colitis (UC)?
Based on 5 studies with 400 participants, there is moderate evidence from clinical studies that Curcumin may support Ulcerative Colitis (UC) management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Ulcerative Colitis (UC)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Ulcerative Colitis (UC)
Curcumin per altre condizioni
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