Ginger
herbAlso known as: Zingiber officinale, Ginger Root, Ginger Extract
About
Ginger (Zingiber officinale) is one of the most widely used medicinal plants for digestive complaints worldwide. Its bioactive compounds, gingerols and shogaols, may help accelerate gastric emptying through cholinergic stimulation. Ginger also exhibits antiemetic activity through 5-HT3 receptor antagonism, similar to the mechanism of ondansetron. Research suggests it may be particularly supportive for nausea, functional dyspepsia, and overall digestive comfort.
How It Works
Gingerols and shogaols accelerate gastric emptying by approximately 25% via cholinergic receptor stimulation; antiemetic activity through 5-HT3 serotonin receptor antagonism; anti-inflammatory effects suppressing COX-2 and TNF-alpha in intestinal tissue; prokinetic effect on antroduodenal motility.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Bloating and Intestinal Gas | B | 27 | 4000 | View → |
| Functional Dyspepsia | B | 4 | 300 | View → |
| Gastroesophageal Reflux Disease (GERD) | D | 1 | 50 | View → |
Side Effects
- Heartburn and GI irritation (especially at higher doses or on empty stomach)
- Mild blood-thinning effect at very high doses
- Mouth and throat irritation from raw ginger
- Diarrhea at excessive doses
Drug & Supplement Interactions
- Anticoagulants (warfarin) and antiplatelet drugs (may enhance bleeding risk at high doses)
- Diabetes medications (may lower blood sugar; monitor glucose levels)
- Antihypertensive medications (may have additive blood pressure-lowering effects)
- Gallstone medications (ginger increases bile flow)
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.