Galactooligosaccharides (GOS) ： Irritable Bowel Syndrome (IBS)

References

1. [1] Radhika Baheti et al.. Food Res Int. 2026. Interplay of probiotics, prebiotics, synbiotics and postbiotics: a review of their therapeutic potential for gastrointestinal inflammation. doi:10.1016/j.foodres.2026.118598 PubMed
2. [2] Prashant Singh et al.. Clin Gastroenterol Hepatol. 2025. Is a Simplified, Less Restrictive Low FODMAP Diet Possible? Results From a Double-Blind, Pilot Randomized Controlled Trial. doi:10.1016/j.cgh.2024.04.021 PubMed
3. [3] Shanti Eswaran et al.. Clin Gastroenterol Hepatol. 2025. All FODMAPs Aren't Created Equal: Results of a Randomized Reintroduction Trial in Patients With Irritable Bowel Syndrome. doi:10.1016/j.cgh.2024.03.047 PubMed
4. [4] Sheida Zeraattalab-Motlagh et al.. Nutr Rev. 2025. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical … doi:10.1093/nutrit/nuae107 PubMed
5. [5] Qi Yao et al.. Nutrients. 2025. Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating Mast Cell Hyperactivation. doi:10.3390/nu17101670 PubMed
6. [6] Aleksandra M Torbica et al.. Foods. 2025. FODMAP Profile of Wholegrain Pasta. doi:10.3390/foods14040667 PubMed
7. [7] Çağlar Akçalı et al.. Sci Rep. 2025. A randomized trial of inulin for bowel symptoms, depression and quality of life in constipation predominant IBS. doi:10.1038/s41598-025-16321-w PubMed
8. [8] Aleksandra M Torbica et al.. Foods. 2025. Biotechnological Tools for the Production of Low-FODMAP Wholegrain Wheat and Rye Cookies and Crackers. doi:10.3390/foods14040582 PubMed
9. [9] Yusuf Serhat Karakülah et al.. Int J Mol Sci. 2025. Clinical Applications of Bovine Colostrum in GastrointestinaI Disorders: Mechanisms, Evidence, and Therapeutic Potential. doi:10.3390/ijms262110673 PubMed
10. [10] Line Graser Jensen et al.. Gastroenterol Res Pract. 2025. Modification of the Low FODMAP Diet Is Feasible in the Treatment of Irritable Bowel Syndrome: A Randomised Crossover Study. doi:10.1155/grp/4152978 PubMed
11. [11] Wing-Yan Wong et al.. Food Funct. 2025. A non-pharmacological intervention for insomnia: tryptophan-fructooligosaccharides combination improves sleep in mice via anti-inflammation and gut microbiota modulation. doi:10.1039/d5fo01651g PubMed
12. [12] Karen Van den Houte et al.. Gastroenterology. 2024. Efficacy and Findings of a Blinded Randomized Reintroduction Phase for the Low FODMAP Diet in Irritable Bowel Syndrome. doi:10.1053/j.gastro.2024.02.008 PubMed
13. [13] Marcus Schmidt et al.. Crit Rev Food Sci Nutr. 2024. FODMAP reduction strategies for nutritionally valuable baking products: current state and future challenges. doi:10.1080/10408398.2023.2195026 PubMed
14. [14] Anita Gąsiorowska et al.. J Clin Med. 2024. Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel … doi:10.3390/jcm14010006 PubMed
15. [15] María Del C Toca et al.. Arch Argent Pediatr. 2024. Postbiotics: A new member in the biotics family. doi:10.5546/aap.2023-10168.eng PubMed
16. [16] Sarvesh V Surve et al.. J Appl Microbiol. 2024. Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. doi:10.1093/jambio/lxae035 PubMed
17. [17] Sean M Garvey et al.. Gastro Hep Adv. 2024. Safety and Tolerability of Microbial Inulinase Supplementation in Healthy Adults: A Randomized, Placebo-Controlled Trial. doi:10.1016/j.gastha.2024.05.013 PubMed
18. [18] Justin L Guice et al.. Front Nutr. 2023. Microbial inulinase promotes fructan hydrolysis under simulated gastric conditions. doi:10.3389/fnut.2023.1129329 PubMed
19. [19] Woori Na et al.. Nutr Res Pract. 2023. Food contributing to fermentable oligosaccharide, disaccharide, monosaccharide, and polyols intake in Korean adults. doi:10.4162/nrp.2023.17.6.1201 PubMed
20. [20] V N Drozdov et al.. Vopr Pitan. 2023. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … doi:10.33029/0042-8833-2023-92-4-92-103 PubMed
21. [21] Ashinshana U Illippangama et al.. Carbohydr Polym. 2022. Inulin as a functional ingredient and their applications in meat products. doi:10.1016/j.carbpol.2021.118706 PubMed
22. [22] Andrew Thomas et al.. Am J Lifestyle Med. 2022. Dietary Modification for the Restoration of Gut Microbiome and Management of Symptoms in Irritable Bowel Syndrome. doi:10.1177/15598276211012968 PubMed
23. [23] J B J Kamphuis et al.. FASEB J. 2022. Increased fermentable carbohydrate intake alters colonic mucus barrier function through glycation processes and increased mast cell counts. doi:10.1096/fj.202100494RRR PubMed
24. [24] Anita Gąsiorowska et al.. J Clin Med. 2022. Effects of Microencapsulated Sodium Butyrate, Probiotics and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome: A Study Protocol of … doi:10.3390/jcm11216587 PubMed
25. [25] Uzma Mustafa et al.. Indian J Gastroenterol. 2022. The challenges of implementing low fermentable oligo-, di-, mono-saccharides and polyol diet in India: An analysis of available data. doi:10.1007/s12664-022-01250-7 PubMed
26. [26] Susie Jung et al.. Nutrients. 2022. A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effects of Multi-Strain Synbiotic in Patients with Functional Diarrhea and High Fecal … doi:10.3390/nu14235017 PubMed
27. [27] Diego Currò. Expert Rev Gastroenterol Hepatol. 2022. Current evidence on the therapeutic use of fiber in irritable bowel syndrome. doi:10.1080/17474124.2021.1924057 PubMed
28. [28] Marcel Skejovic Joehnke et al.. Food Chem X. 2021. Nutritional and anti-nutritional properties of lentil (Lens culinaris) protein isolates prepared by pilot-scale processing. doi:10.1016/j.fochx.2020.100112 PubMed
29. [29] Christopher J Black et al.. Frontline Gastroenterol. 2021. Best management of irritable bowel syndrome. doi:10.1136/flgastro-2019-101298 PubMed
30. [30] Cristina Iribarren et al.. Nutrients. 2021. The Effects of Human Milk Oligosaccharides on Gut Microbiota, Metabolite Profiles and Host Mucosal Response in Patients with Irritable Bowel … doi:10.3390/nu13113836 PubMed
31. [31] Johannes Pitsch et al.. Foods. 2021. FODMAP Fingerprinting of Bakery Products and Sourdoughs: Quantitative Assessment and Content Reduction through Fermentation. doi:10.3390/foods10040894 PubMed
32. [32] Elodie Schneider et al.. J Nutr. 2021. FODMAP Consumption by Adults from the French Population-Based NutriNet-Santé Cohort. doi:10.1093/jn/nxab207 PubMed
33. [33] Teodora Surdea-Blaga et al.. Curr Opin Gastroenterol. 2021. Dietary interventions and irritable bowel syndrome - what really works? doi:10.1097/MOG.0000000000000706 PubMed
34. [34] Lena Böhn et al.. Neurogastroenterol Motil. 2021. A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … doi:10.1111/nmo.14094 PubMed
35. [35] Selina R Cox et al.. Gastroenterology. 2020. Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease … doi:10.1053/j.gastro.2019.09.024 PubMed
36. [36] Barbara Skrzydło-Radomańska et al.. Nutrients. 2020. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant … doi:10.3390/nu12071999 PubMed
37. [37] Bridgette Wilson et al.. Am J Gastroenterol. 2020. β-Galactooligosaccharide in Conjunction With Low FODMAP Diet Improves Irritable Bowel Syndrome Symptoms but Reduces Fecal Bifidobacteria. doi:10.14309/ajg.0000000000000641 PubMed
38. [38] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
39. [39] Jasper B J Kamphuis et al.. Gastroenterology. 2020. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. doi:10.1053/j.gastro.2019.10.037 PubMed
40. [40] Jitka Laurent et al.. Int J Food Microbiol. 2020. Variability in yeast invertase activity determines the extent of fructan hydrolysis during wheat dough fermentation and final FODMAP levels in … doi:10.1016/j.ijfoodmicro.2020.108648 PubMed
41. [41] Khadijeh Abhari et al.. Eur J Nutr. 2020. Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management? doi:10.1007/s00394-019-02060-y PubMed
42. [42] Paul Moayyedi et al.. J Can Assoc Gastroenterol. 2019. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS). doi:10.1093/jcag/gwy071 PubMed
43. [43] Bridgette Wilson et al.. Am J Clin Nutr. 2019. Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled … doi:10.1093/ajcn/nqy376 PubMed
44. [44] Xiao Jing Wang et al.. Aliment Pharmacol Ther. 2019. Review article: biological mechanisms for symptom causation by individual FODMAP subgroups - the case for a more personalised approach to … doi:10.1111/apt.15419 PubMed
45. [45] Praveena Thirunathan et al.. Crit Rev Food Sci Nutr. 2019. Processing methods for reducing alpha-galactosides in pulses. doi:10.1080/10408398.2018.1490886 PubMed
46. [46] Ewa Pejcz et al.. Foods. 2019. Technological Methods for Reducing the Content of Fructan in Wheat Bread. doi:10.3390/foods8120663 PubMed
47. [47] Afrin Kamal et al.. Am J Gastroenterol. 2019. Influence of Dietary Restriction on Irritable Bowel Syndrome. doi:10.1038/s41395-018-0241-2 PubMed
48. [48] Megan Rossi et al.. Clin Gastroenterol Hepatol. 2018. Volatile Organic Compounds in Feces Associate With Response to Dietary Intervention in Patients With Irritable Bowel Syndrome. doi:10.1016/j.cgh.2017.09.055 PubMed
49. [49] C J Tuck et al.. Am J Gastroenterol. 2018. Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. doi:10.1038/ajg.2017.245 PubMed
50. [50] Tobias Pöhnl et al.. J Agric Food Chem. 2018. Impact of Cultivation Method and Cultivar Selection on Soluble Carbohydrates and Pungent Principles in Onions ( Allium cepa L.). doi:10.1021/acs.jafc.8b05018 PubMed
51. [51] Bridgette Wilson et al.. J Gastroenterol Hepatol. 2017. Prebiotic inulin-type fructans and galacto-oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders. doi:10.1111/jgh.13700 PubMed
52. [52] Jane Varney et al.. J Gastroenterol Hepatol. 2017. FODMAPs: food composition, defining cutoff values and international application. doi:10.1111/jgh.13698 PubMed
53. [53] Magdy El-Salhy et al.. Int J Mol Med. 2017. Dietary fiber in irritable bowel syndrome (Review). doi:10.3892/ijmm.2017.3072 PubMed
54. [54] F Azpiroz et al.. Neurogastroenterol Motil. 2017. Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double … doi:10.1111/nmo.12911 PubMed
55. [55] Selina R Cox et al.. J Crohns Colitis. 2017. Fermentable Carbohydrates [FODMAPs] Exacerbate Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: A Randomised, Double-blind, Placebo-controlled, Cross-over, Re-challenge Trial. doi:10.1093/ecco-jcc/jjx073 PubMed
56. [56] Emma P Halmos. J Gastroenterol Hepatol. 2017. When the low FODMAP diet does not work. doi:10.1111/jgh.13701 PubMed
57. [57] Eirini Dimidi et al.. Curr Opin Clin Nutr Metab Care. 2017. Irritable bowel syndrome and diet: where are we in 2018? doi:10.1097/MCO.0000000000000416 PubMed
58. [58] Jennifer Erickson et al.. Nutr J. 2017. Gastrointestinal tolerance of low FODMAP oral nutrition supplements in healthy human subjects: a randomized controlled trial. doi:10.1186/s12937-017-0256-3 PubMed
59. [59] H M Staudacher et al.. Aliment Pharmacol Ther. 2017. Editorial: metabolic adaptation of colonic microbiota to galactooligosaccharides - good news for prebiotics in irritable bowel syndrome? doi:10.1111/apt.13976 PubMed
60. [60] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
61. [61] Markku Hillilä et al.. Scand J Gastroenterol. 2016. Does oral α-galactosidase relieve irritable bowel symptoms? doi:10.3109/00365521.2015.1063156 PubMed
62. [62] Martin Raithel et al.. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016. [Non-allergic gluten sensitivity. A controversial disease - or not yet sufficiently explored?]. doi:10.1007/s00103-016-2366-z PubMed
63. [63] Marina Iacovou et al.. J Neurogastroenterol Motil. 2015. The Low FODMAP Diet and Its Application in East and Southeast Asia. doi:10.5056/jnm15111 PubMed
64. [64] Heidi M Staudacher et al.. J Nutr. 2012. Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. doi:10.3945/jn.112.159285 PubMed
65. [65] Michael de Vrese. Menopause Int. 2009. Health benefits of probiotics and prebiotics in women. doi:10.1258/mi.2009.009008 PubMed
66. [66] Angelo Andriulli et al.. J Clin Gastroenterol. 2008. Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized … doi:10.1097/MCG.0b013e31817fadd6 PubMed
67. [67] S Macfarlane et al.. Aliment Pharmacol Ther. 2006. Review article: prebiotics in the gastrointestinal tract. doi:10.1111/j.1365-2036.2006.03042.x PubMed
68. [68] W Scheppach et al.. Br J Nutr. 2001. Beneficial health effects of low-digestible carbohydrate consumption. doi:10.1079/bjn2000259 PubMed
69. [69] M Olesen et al.. Am J Clin Nutr. 2000. Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome. doi:10.1093/ajcn/72.6.1570 PubMed