Aloe Vera (Inner Leaf Gel) ： Irritable Bowel Syndrome (IBS)
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Small RCTs show modest improvement in IBS symptoms. Conflicting results; some studies show no benefit over placebo.
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C
結論
Small RCTs show modest improvement in IBS symptoms. Conflicting results; some studies show no benefit over placebo.
Key Study Findings
Review
Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: patients with IBS (review of plant extracts including peppermint oil, Iberogast, curcumin)
Review
Natural Products for the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Patients with irritable bowel syndrome
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
vs: Various
Outcome: IBS symptom improvement
効果: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
対象集団: Adult IBS patients
Controlled Clinical Trial
n=43
4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d
vs: None
Outcome: None
効果: None
None
対象集団: IBS patients
Randomized Controlled Trial
n=160
Double-blind
Food supplements and diet as treatment options in irritable bowel syndrome.
Dose: None
vs: Placebo
Outcome: None
効果: None
None
対象集団: IBS patients
Meta-Analysis
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Dose: None
vs: Placebo
Outcome: efficacy of Western herbal medicines in the treatment …
効果: None
None
対象集団: IBS patients
Key Statistics
3
研究数
250
参加者数
↔
Mixed
C
グレード
Referenced Papers
Nutrients
2026
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
Nutrition reviews
2025
10 件の引用
Gastroenterology & hepatology
2025
Nutrition research (New …
2020
42 件の引用
Neurogastroenterology and motility
2020
34 件の引用
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
Complementary therapies in …
2020
34 件の引用
Nutrients
2019
26 件の引用
Nutrients
2018
54 件の引用
Journal of neurogastroenterology …
2018
33 件の引用
Journal of gastrointestinal …
2015
36 件の引用
Journal of research …
2013
Chinese journal of …
2012
30 件の引用
ISRN gastroenterology
2011
30 件の引用
International journal of …
2006
50 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
- ibssupport:
- 100 mL twice daily for 1-3 months
- constipation:
- 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)
上限量： No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 5 g/d | 4 weeks | Positive | 43 |
| None | -- | Positive | 160 |
| None | -- | Positive | -- |
| 500 mg | 2.0 weeks | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： Before meals; aloe latex should only be used short-term for constipation
Safety & Side Effects
報告されている副作用
- ⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
- ⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
- ⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
- ⚠ Allergic skin reactions in sensitive individuals
既知の相互作用
- ● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
- ● Diuretics (additive potassium loss with aloe latex)
- ● Diabetes medications (aloe may lower blood sugar; monitor glucose)
- ● Stimulant laxatives (additive laxative effect; avoid combining)
- ● Anticoagulants (theoretical interaction due to platelet effects)
耐容上限摂取量： No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Aloe Vera (Inner Leaf Gel) help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Aloe Vera (Inner Leaf Gel) may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Aloe Vera (Inner Leaf Gel) should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is mixed.
Related Evidence
に関する他の成分： Irritable Bowel Syndrome (IBS)
Aloe Vera (Inner Leaf Gel) 他の症状・状態について
References
- [1] Ploutarchos Pastras et al.. Nutrients. 2026. Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines. doi:10.3390/nu18020183 PubMed
- [2] Sheida Zeraattalab-Motlagh et al.. Nutr Rev. 2025. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical … doi:10.1093/nutrit/nuae107 PubMed
- [3] Sophie Brigstocke et al.. Gastroenterol Hepatol (N Y). 2025. Natural Products for the Treatment of Irritable Bowel Syndrome. PubMed
- [4] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
- [5] Eirini Dimidi et al.. Neurogastroenterol Motil. 2020. Food supplements and diet as treatment options in irritable bowel syndrome. doi:10.1111/nmo.13951 PubMed
- [6] Jason A Hawrelak et al.. Complement Ther Med. 2020. Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis. doi:10.1016/j.ctim.2019.102233 PubMed
- [7] Carmen Parisio et al.. Nutrients. 2019. Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin. doi:10.3390/nu12010022 PubMed
- [8] Amanda C Fifi et al.. Nutrients. 2018. Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials. doi:10.3390/nu10111715 PubMed
- [9] Seung Wook Hong et al.. J Neurogastroenterol Motil. 2018. Aloe vera Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis. doi:10.5056/jnm18077 PubMed
- [10] Stine Størsrud et al.. J Gastrointestin Liver Dis. 2015. A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, … doi:10.15403/jgld.2014.1121.243.sst PubMed
- [11] Hossein Khedmat et al.. J Res Med Sci. 2013. Aloe vera in treatment of refractory irritable bowel syndrome: Trial on Iranian patients. PubMed
- [12] Azar Asadi-Shahmirzadi et al.. Chin J Integr Med. 2012. Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects. doi:10.1007/s11655-012-1027-9 PubMed
- [13] H A Hutchings et al.. ISRN Gastroenterol. 2011. A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life. doi:10.5402/2011/206103 PubMed
- [14] K Davis et al.. Int J Clin Pract. 2006. Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome. doi:10.1111/j.1742-1241.2006.00980.x PubMed
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。