Aloe Vera (Inner Leaf Gel) untuk Irritable Bowel Syndrome (IBS)
C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.Small RCTs show modest improvement in IBS symptoms. Conflicting results; some studies show no benefit over placebo.
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C
Kesimpulan
Small RCTs show modest improvement in IBS symptoms. Conflicting results; some studies show no benefit over placebo.
Key Study Findings
Review
Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: patients with IBS (review of plant extracts including peppermint oil, Iberogast, curcumin)
Review
Natural Products for the Treatment of Irritable Bowel Syndrome.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Patients with irritable bowel syndrome
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
vs: Various
Outcome: IBS symptom improvement
Efek: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
Populasi: Adult IBS patients
Controlled Clinical Trial
n=43
4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d
vs: None
Outcome: None
Efek: None
None
Populasi: IBS patients
Randomized Controlled Trial
n=160
Double-blind
Food supplements and diet as treatment options in irritable bowel syndrome.
Dose: None
vs: Placebo
Outcome: None
Efek: None
None
Populasi: IBS patients
Meta-Analysis
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Dose: None
vs: Placebo
Outcome: efficacy of Western herbal medicines in the treatment …
Efek: None
None
Populasi: IBS patients
Key Statistics
3
Studi
250
Peserta
↔
Mixed
C
Peringkat
Referenced Papers
Nutrients
2026
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
Nutrition reviews
2025
10 sitasi
Gastroenterology & hepatology
2025
Nutrition research (New …
2020
42 sitasi
Neurogastroenterology and motility
2020
34 sitasi
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
Complementary therapies in …
2020
34 sitasi
Nutrients
2019
26 sitasi
Nutrients
2018
54 sitasi
Journal of neurogastroenterology …
2018
33 sitasi
Journal of gastrointestinal …
2015
36 sitasi
Journal of research …
2013
Chinese journal of …
2012
30 sitasi
ISRN gastroenterology
2011
30 sitasi
International journal of …
2006
50 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
- ibssupport:
- 100 mL twice daily for 1-3 months
- constipation:
- 100-300 mg aloe latex (short-term only, maximum 1-2 weeks)
Batas atas: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 5 g/d | 4 weeks | Positive | 43 |
| None | -- | Positive | 160 |
| None | -- | Positive | -- |
| 500 mg | 2.0 weeks | Positive | -- |
| None | -- | Mixed | -- |
Waktu terbaik diminum: Before meals; aloe latex should only be used short-term for constipation
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
- ⚠ Electrolyte imbalance (hypokalemia) with chronic laxative use
- ⚠ Potential hepatotoxicity with long-term whole leaf consumption (rare)
- ⚠ Allergic skin reactions in sensitive individuals
Interaksi yang Diketahui
- ● Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
- ● Diuretics (additive potassium loss with aloe latex)
- ● Diabetes medications (aloe may lower blood sugar; monitor glucose)
- ● Stimulant laxatives (additive laxative effect; avoid combining)
- ● Anticoagulants (theoretical interaction due to platelet effects)
Asupan atas yang dapat ditoleransi: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Aloe Vera (Inner Leaf Gel) help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Aloe Vera (Inner Leaf Gel) may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Aloe Vera (Inner Leaf Gel) should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is mixed.
Related Evidence
Bahan lain untuk Irritable Bowel Syndrome (IBS)
Aloe Vera (Inner Leaf Gel) untuk kondisi lain
References
- [1] Ploutarchos Pastras et al.. Nutrients. 2026. Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines. doi:10.3390/nu18020183 PubMed
- [2] Sheida Zeraattalab-Motlagh et al.. Nutr Rev. 2025. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical … doi:10.1093/nutrit/nuae107 PubMed
- [3] Sophie Brigstocke et al.. Gastroenterol Hepatol (N Y). 2025. Natural Products for the Treatment of Irritable Bowel Syndrome. PubMed
- [4] Karin Ried et al.. Nutr Res. 2020. Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. doi:10.1016/j.nutres.2020.02.008 PubMed
- [5] Eirini Dimidi et al.. Neurogastroenterol Motil. 2020. Food supplements and diet as treatment options in irritable bowel syndrome. doi:10.1111/nmo.13951 PubMed
- [6] Jason A Hawrelak et al.. Complement Ther Med. 2020. Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis. doi:10.1016/j.ctim.2019.102233 PubMed
- [7] Carmen Parisio et al.. Nutrients. 2019. Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin. doi:10.3390/nu12010022 PubMed
- [8] Amanda C Fifi et al.. Nutrients. 2018. Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials. doi:10.3390/nu10111715 PubMed
- [9] Seung Wook Hong et al.. J Neurogastroenterol Motil. 2018. Aloe vera Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis. doi:10.5056/jnm18077 PubMed
- [10] Stine Størsrud et al.. J Gastrointestin Liver Dis. 2015. A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, … doi:10.15403/jgld.2014.1121.243.sst PubMed
- [11] Hossein Khedmat et al.. J Res Med Sci. 2013. Aloe vera in treatment of refractory irritable bowel syndrome: Trial on Iranian patients. PubMed
- [12] Azar Asadi-Shahmirzadi et al.. Chin J Integr Med. 2012. Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects. doi:10.1007/s11655-012-1027-9 PubMed
- [13] H A Hutchings et al.. ISRN Gastroenterol. 2011. A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life. doi:10.5402/2011/206103 PubMed
- [14] K Davis et al.. Int J Clin Pract. 2006. Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome. doi:10.1111/j.1742-1241.2006.00980.x PubMed
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