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Aloe Vera (Inner Leaf Gel) per Irritable Bowel Syndrome (IBS)

C

Small RCTs show modest improvement in IBS symptoms. Conflicting results; some studies show no benefit over placebo.

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C

In sintesi

Small RCTs show modest improvement in IBS symptoms. Conflicting results; some studies show no benefit over placebo.

Key Study Findings

Review
Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines.
Dose: None vs: None Outcome: None Effetto: None None

Popolazione: patients with IBS (review of plant extracts including peppermint oil, Iberogast, curcumin)

Review
Natural Products for the Treatment of Irritable Bowel Syndrome.
Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Patients with irritable bowel syndrome

Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None vs: Various Outcome: IBS symptom improvement Effetto: Probiotics abdominal pain RR 4.04 (2.36-6.92) None

Popolazione: Adult IBS patients

Controlled Clinical Trial n=43 4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d vs: None Outcome: None Effetto: None None

Popolazione: IBS patients

Randomized Controlled Trial n=160 Double-blind
Food supplements and diet as treatment options in irritable bowel syndrome.
Dose: None vs: Placebo Outcome: None Effetto: None None

Popolazione: IBS patients

Meta-Analysis
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Dose: None vs: Placebo Outcome: efficacy of Western herbal medicines in the treatment … Effetto: None None

Popolazione: IBS patients

Key Statistics

3

Studi

250

Partecipanti

Mixed

C

Grado

Referenced Papers

Neurogastroenterology and motility 2020 34 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:
100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
ibssupport:
100 mL twice daily for 1-3 months
constipation:
100-300 mg aloe latex (short-term only, maximum 1-2 weeks)

Limite massimo: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Dosaggi studiati nella ricerca

Dosaggio Durata Effetto N
None -- Mixed --
None -- Mixed --
None -- Positive --
5 g/d 4 weeks Positive 43
None -- Positive 160
None -- Positive --
500 mg 2.0 weeks Positive --
None -- Mixed --

Momento migliore per l'assunzione: Before meals; aloe latex should only be used short-term for constipation

Safety & Side Effects

Effetti collaterali segnalati

  • Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
  • Electrolyte imbalance (hypokalemia) with chronic laxative use
  • Potential hepatotoxicity with long-term whole leaf consumption (rare)
  • Allergic skin reactions in sensitive individuals

Interazioni note

  • Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
  • Diuretics (additive potassium loss with aloe latex)
  • Diabetes medications (aloe may lower blood sugar; monitor glucose)
  • Stimulant laxatives (additive laxative effect; avoid combining)
  • Anticoagulants (theoretical interaction due to platelet effects)

Livello di assunzione massimo tollerabile: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Aloe Vera (Inner Leaf Gel) help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Aloe Vera (Inner Leaf Gel) may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Aloe Vera (Inner Leaf Gel) should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is mixed.

Related Evidence

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.