L-Glutamine के लिए Crohn's Disease
C साक्ष्य की तुलना करें छोटे अध्ययनों से सीमित साक्ष्य उपलब्ध हैं, लेकिन कुछ सकारात्मक संकेत मौजूद हैं।Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.
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C
निष्कर्ष
Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.
Key Study Findings
Other
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.
Dose: None
बनाम: None
Outcome: Gut microbiota composition
प्रभाव: None
None
जनसंख्या: Crohn's disease patients
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
बनाम: None
Outcome: Cholesterol levels
प्रभाव: None
None
जनसंख्या: Mouse model
Controlled Clinical Trial
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study.
Dose: Washed microbiota transplantation (WMT)
बनाम: Pre-treatment baseline
Outcome: Clinical remission and multi-omics changes
प्रभाव: None
None
जनसंख्या: Patients with Crohn's disease
In Vitro
Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.
Dose: Beclin1 constitutive activation (genetic)
बनाम: Wild-type mice
Outcome: Cytokine production in macrophage activation
प्रभाव: None
None
जनसंख्या: Beclin1 variant mice + AIEC infection
Observational Study
n=262
Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in …
Dose: Phenylacetylglutamine (PAGln, measured)
बनाम: Healthy controls (n=126)
Outcome: PAGln association with CD and colitis
प्रभाव: None
None
जनसंख्या: New-onset treatment-naive CD (n=136) + controls
Observational Study
COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN BRAZILIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
Dose: None
बनाम: None
Outcome: CAM use patterns in IBD patients
प्रभाव: None
None
जनसंख्या: Brazilian IBD patients
Key Statistics
3
अध्ययन
200
प्रतिभागी
↑
Positive
C
ग्रेड
Referenced Papers
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.
Other
EMBO molecular medicine
2024
13 उद्धरण
Cannabis and cannabinoid …
2024
10 उद्धरण
World journal of …
2024
Cell reports
2023
27 उद्धरण
Journal of Crohn's …
2023
24 उद्धरण
JCI insight
2022
24 उद्धरण
Sheng wu gong …
2022
4 उद्धरण
COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN BRAZILIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
Other
Arquivos de gastroenterologia
2022
4 उद्धरण
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Systematic Review
Clinical nutrition ESPEN
2021
39 उद्धरण
Gastroenterology
2019
118 उद्धरण
Journal of cellular …
2019
23 उद्धरण
The Cochrane database …
2018
425 उद्धरण
Gastroenterology clinics of …
2018
67 उद्धरण
Clinical medicine insights. …
2018
15 उद्धरण
Nutrition in clinical …
2018
10 उद्धरण
Current opinion in …
2017
37 उद्धरण
JPEN. Journal of …
2017
24 उद्धरण
World journal of …
2017
21 उद्धरण
The AAPS journal
2017
Glutamine for induction of remission in Crohn's disease.
Systematic Review
The Cochrane database …
2016
37 उद्धरण
Scandinavian journal of …
2014
56 उद्धरण
Digestive diseases and …
2012
81 उद्धरण
Frontline gastroenterology
2012
20 उद्धरण
Plasma citrulline concentration as a marker for disease activity in patients with Crohn's disease.
Other
Journal of clinical …
2012
13 उद्धरण
Pediatrics in review
2012
International journal of …
2011
12 उद्धरण
Inflammatory bowel diseases
2010
89 उद्धरण
Nutricion hospitalaria
2010
Nutrition in clinical …
2009
36 उद्धरण
The Journal of …
2008
89 उद्धरण
Molecular nutrition & …
2008
26 उद्धरण
The Cochrane database …
2007
192 उद्धरण
Digestive diseases and …
2006
73 उद्धरण
Immunonutrition.
Review
Current opinion in …
2005
22 उद्धरण
JPEN. Journal of …
2005
19 उद्धरण
Clinical nutrition (Edinburgh, …
2004
18 उद्धरण
Medycyna wieku rozwojowego
2004
1 उद्धरण
Annali italiani di …
2004
Alimentary pharmacology & …
2003
179 उद्धरण
Nutricion hospitalaria
2003
Revista do Hospital …
2002
39 उद्धरण
Scandinavian journal of …
2002
28 उद्धरण
Enteral feeding.
Other
Current opinion in …
2002
1 उद्धरण
Enteral feeding.
Review
Current opinion in …
2002
Enteral nutritional therapy for inducing remission of Crohn's disease.
Systematic Review
The Cochrane database …
2001
149 उद्धरण
Journal of pediatric …
2000
187 उद्धरण
Current opinion in …
2000
21 उद्धरण
JPEN. Journal of …
2000
18 उद्धरण
JPEN. Journal of …
1999
129 उद्धरण
Diseases of the …
1998
26 उद्धरण
Zeitschrift fur Gastroenterologie
1998
18 उद्धरण
FASEB journal : …
1997
170 उद्धरण
Schweizerische medizinische Wochenschrift. …
1996
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
अधिकतम सीमा: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Washed microbiota transplantation (WMT) | -- | Positive | -- |
| Beclin1 constitutive activation (genetic) | -- | Positive | -- |
| Phenylacetylglutamine (PAGln, measured) | -- | Negative | 262 |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
सेवन का सर्वोत्तम समय: Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
ज्ञात अंतःक्रियाएँ
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
सहनीय अधिकतम सेवन: Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does L-Glutamine help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that L-Glutamine may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much L-Glutamine should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Crohn's Disease
L-Glutamine अन्य स्वास्थ्य स्थितियों के लिए
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FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।