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L-Glutamine pour Crohn's Disease

C

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

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C

En conclusion

Small RCTs show glutamine (0.5 g/kg/day) improves intestinal permeability and morphology in Crohn's patients. Evidence limited by small sample sizes.

Key Study Findings

Other
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.
Dose: None vs: None Outcome: Gut microbiota composition Effet: None None

Population: Crohn's disease patients

Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None vs: None Outcome: Cholesterol levels Effet: None None

Population: Mouse model

Controlled Clinical Trial
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study.
Dose: Washed microbiota transplantation (WMT) vs: Pre-treatment baseline Outcome: Clinical remission and multi-omics changes Effet: None None

Population: Patients with Crohn's disease

In Vitro
Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.
Dose: Beclin1 constitutive activation (genetic) vs: Wild-type mice Outcome: Cytokine production in macrophage activation Effet: None None

Population: Beclin1 variant mice + AIEC infection

Observational Study n=262
Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in …
Dose: Phenylacetylglutamine (PAGln, measured) vs: Healthy controls (n=126) Outcome: PAGln association with CD and colitis Effet: None None

Population: New-onset treatment-naive CD (n=136) + controls

Observational Study
COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN BRAZILIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
Dose: None vs: None Outcome: CAM use patterns in IBD patients Effet: None None

Population: Brazilian IBD patients

Key Statistics

3

Études

200

Participants

Positive

C

Note

Referenced Papers

Sheng wu gong … 2022 4 citations
The Cochrane database … 2018 425 citations
Gastroenterology clinics of … 2018 67 citations
Current opinion in … 2017 37 citations
The Cochrane database … 2016 37 citations
Inflammatory bowel diseases 2010 89 citations
The Cochrane database … 2007 192 citations
Current opinion in … 2005 22 citations
Clinical nutrition (Edinburgh, … 2004 18 citations
Alimentary pharmacology & … 2003 179 citations
Revista do Hospital … 2002 39 citations
Current opinion in … 2002 1 citations
Current opinion in … 2002
The Cochrane database … 2001 149 citations
Current opinion in … 2000 21 citations
Diseases of the … 1998 26 citations
Zeitschrift fur Gastroenterologie 1998 18 citations
Schweizerische medizinische Wochenschrift. … 1996

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:
5-15 g/day
ibsdsupport:
5 g three times daily (15 g/day total)
postexercisegut:
0.25-0.9 g/kg before intense exercise
gutbarriersupport:
0.5 g/kg/day (approximately 30-40 g/day for adults)

Limite supérieure : Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Posologies étudiées dans la recherche

Posologie Durée Effet N
None -- Positive --
None -- Positive --
Washed microbiota transplantation (WMT) -- Positive --
Beclin1 constitutive activation (genetic) -- Positive --
Phenylacetylglutamine (PAGln, measured) -- Negative 262
None -- Mixed --
None -- Negative --
None -- Mixed --

Moment optimal de prise : Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Effets indésirables signalés

  • Mild gastrointestinal discomfort at high doses
  • Headache
  • Dizziness at very high doses
  • Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Interactions connues

  • Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
  • Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
  • Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Apport maximal tolérable : Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does L-Glutamine help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that L-Glutamine may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much L-Glutamine should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.