Curcumin के लिए Crohn's Disease
CLimited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
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C
निष्कर्ष
Limited RCT evidence. Some improvement in CDAI scores but results inconsistent. Better evidence exists for UC than Crohn's.
Key Study Findings
Meta-Analysis
n=2260
Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: …
Dose: None
बनाम: placebo or other medical therapies
Outcome: endoscopic recurrence (Rutgeerts score >= i2) at 6 …
प्रभाव: adalimumab vs thiopurines OR 0.33 (95% CI 0.12-0.91); adalimumab vs vitamin D OR 0.07 (95% CI 0.01-0
None
जनसंख्या: patients with Crohn's disease post-surgery from 42 studies (38 RCTs)
Meta-Analysis
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of …
Dose: Varying dosages
बनाम: Placebo
Outcome: Clinical remission and response in UC
प्रभाव: None
None
जनसंख्या: UC and CD patients (13 RCTs)
Systematic Review
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Dose: Peppermint oil, STW-5, psyllium, others
बनाम: Standard care or placebo
Outcome: Symptom improvement in GI diseases
प्रभाव: None
None
जनसंख्या: Patients with gastroenterological diseases
Review
Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease.
Dose: Curcumin nanoformulations
बनाम: None
Outcome: IBD symptom improvement
प्रभाव: None
None
जनसंख्या: IBD patients (preclinical/clinical review)
Review
Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and …
Dose: Various phytochemicals
बनाम: None
Outcome: NF-kB regulation in IBD
प्रभाव: None
None
जनसंख्या: In vitro and in vivo IBD models
Meta-Analysis
Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A …
Dose: None
बनाम: Placebo or standard care
Outcome: Clinical/laboratory outcomes in autoimmune diseases
प्रभाव: None
None
जनसंख्या: Patients with 10 types of autoimmune diseases
Key Statistics
3
अध्ययन
200
प्रतिभागी
↔
Mixed
C
ग्रेड
Referenced Papers
Inflammatory bowel diseases
2026
Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Systematic Review
Frontiers in nutrition
2025
8 उद्धरण
[Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review].
Systematic Review
Zeitschrift fur Gastroenterologie
2024
3 उद्धरण
World journal of …
2024
Metabolites
2023
134 उद्धरण
Frontiers in immunology
2022
68 उद्धरण
Molecules (Basel, Switzerland)
2021
85 उद्धरण
Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review.
Meta-Analysis
Journal of medicinal …
2021
52 उद्धरण
United European gastroenterology …
2021
41 उद्धरण
European journal of …
2021
40 उद्धरण
A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
Systematic Review
Advances in experimental …
2021
8 उद्धरण
Journal of Crohn's …
2020
71 उद्धरण
Clinical gastroenterology and …
2020
49 उद्धरण
The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.
Systematic Review
Nutrients
2020
48 उद्धरण
Nutrients
2020
30 उद्धरण
Digestive and liver …
2020
14 उद्धरण
Medicine
2020
4 उद्धरण
International journal of …
2019
137 उद्धरण
Critical reviews in …
2019
48 उद्धरण
Journal of medicinal …
2019
17 उद्धरण
Current opinion in …
2019
5 उद्धरण
Gastroenterology clinics of …
2018
67 उद्धरण
Macromolecular bioscience
2018
13 उद्धरण
Gastroenterology
2017
335 उद्धरण
Medical principles and …
2017
45 उद्धरण
JPEN. Journal of …
2017
24 उद्धरण
Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review.
Systematic Review
Complementary therapies in …
2017
23 उद्धरण
The Medical clinics …
2017
9 उद्धरण
Ugeskrift for laeger
2017
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 उद्धरण
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
Systematic Review
Journal of Crohn's …
2015
184 उद्धरण
Annals of gastroenterology
2015
135 उद्धरण
Molecules (Basel, Switzerland)
2014
122 उद्धरण
Experimental cell research
2014
16 उद्धरण
The AAPS journal
2013
1866 उद्धरण
Alimentary pharmacology & …
2013
128 उद्धरण
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Other
Journal of pediatric …
2013
103 उद्धरण
Nature reviews. Gastroenterology …
2013
47 उद्धरण
Food & function
2012
151 उद्धरण
Journal of the …
2009
24 उद्धरण
Molecular nutrition & …
2008
67 उद्धरण
Revista de gastroenterologia …
2008
2 उद्धरण
Digestive diseases and …
2005
461 उद्धरण
Bioinformatics (Oxford, England)
2004
149 उद्धरण
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 500-1,500 mg/day with piperine (black pepper extract) for absorption
- ibssupport:
- 500-1,000 mg/day
- ucmaintenance:
- 2,000 mg/day (1 g twice daily) as adjunct to mesalamine
अधिकतम सीमा: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Positive | 2260 |
| Varying dosages | -- | Positive | -- |
| Peppermint oil, STW-5, psyllium, others | -- | Positive | -- |
| Curcumin nanoformulations | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
सेवन का सर्वोत्तम समय: With meals containing fat and black pepper for enhanced absorption
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ GI discomfort (nausea, diarrhea, abdominal pain) at high doses
- ⚠ Yellow staining of skin/teeth with topical/oral contact
- ⚠ Increased gallbladder contractions (avoid with gallstones or bile duct obstruction)
- ⚠ Iron chelation (may reduce iron absorption at very high doses)
ज्ञात अंतःक्रियाएँ
- ● Anticoagulants (curcumin has antiplatelet properties; may increase bleeding risk)
- ● Chemotherapy agents (curcumin may alter drug metabolism via CYP enzyme inhibition)
- ● Sulfasalazine (additive anti-inflammatory effect — may be beneficial in IBD)
- ● Iron supplements (curcumin may chelate iron; space dosing)
- ● Piperine/black pepper (enhances curcumin bioavailability by 2,000% — commonly co-administered)
सहनीय अधिकतम सेवन: Well-tolerated up to 8 g/day in clinical trials (most studies use 1-2 g/day)
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Curcumin help with Crohn's Disease?
Based on 3 studies with 200 participants, there is limited but promising evidence that Curcumin may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Curcumin should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day with piperine (black pepper extract) for absorption. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include GI discomfort (nausea, diarrhea, abdominal pain) at high doses, Yellow staining of skin/teeth with topical/oral contact, Increased gallbladder contractions (avoid with gallstones or bile duct obstruction), Iron chelation (may reduce iron absorption at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is mixed.
Related Evidence
इसके लिए अन्य सामग्री Crohn's Disease
Curcumin अन्य स्वास्थ्य स्थितियों के लिए
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।