Bifidobacterium lactis के लिए Chronic Constipation
B संबंधित साक्ष्य कम से कम एक यादृच्छिक परीक्षण इसका समर्थन करता है, जिसके परिणाम अधिकतर सुसंगत हैं।Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
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B
निष्कर्ष
Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
Key Study Findings
Randomized Controlled Trial
8 weeks
Double-blind
Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …
Dose: None
बनाम: Placebo
Outcome: Complete spontaneous bowel movements (CSBMs)
प्रभाव: None
None
जनसंख्या: Adults with functional constipation (Rome III)
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
बनाम: Placebo
Outcome: Weekly spontaneous bowel movements
प्रभाव: 4.94 vs 3.00 (P<0.001)
P<0.001
जनसंख्या: Older adults >=60 with functional constipation (Rome IV)
Randomized Controlled Trial
n=35
12 weeks
Double-blind
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …
Dose: None
बनाम: Placebo
Outcome: Gut barrier function (zonulin levels)
प्रभाव: Zonulin -19.5 ng/mL at week 16
p=0.0002 wk16; p=0.0053 grp
जनसंख्या: IBS without constipation patients
Review
An update on probiotics in paediatrics.
Dose: None
बनाम: None
Outcome: GI disorder outcomes in paediatrics
प्रभाव: None
None
जनसंख्या: Paediatric patients with GI disorders
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
बनाम: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
प्रभाव: None
<0.001
जनसंख्या: IBS patients (28) and asymptomatic controls (7)
Randomized Controlled Trial
n=128
2 weeks
Double-blind
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
Dose: 0.5 mL daily for 14 days
बनाम: Placebo
Outcome: Fever duration (days)
प्रभाव: RR 0.64 (95% CI 0.51-0.80)
None
जनसंख्या: Children 28 days-4 years with fever and URTI
Key Statistics
4
अध्ययन
600
प्रतिभागी
↑
Positive
B
ग्रेड
Referenced Papers
JAMA network open
2025
13 उद्धरण
Nutrients
2025
7 उद्धरण
International journal of …
2025
4 उद्धरण
Molecular nutrition & …
2025
2 उद्धरण
The journal of …
2025
Current opinion in …
2025
JAMA network open
2024
9 उद्धरण
European journal of …
2024
9 उद्धरण
Gut microbes
2023
143 उद्धरण
Journal of clinical …
2023
9 उद्धरण
Clinical nutrition (Edinburgh, …
2022
42 उद्धरण
Frontiers in nutrition
2022
24 उद्धरण
Frontiers in nutrition
2022
22 उद्धरण
Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models.
Other
PloS one
2022
21 उद्धरण
Medicine
2022
14 उद्धरण
Frontiers in microbiology
2022
4 उद्धरण
Medicine
2021
8 उद्धरण
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Meta-Analysis
Clinical nutrition (Edinburgh, …
2020
94 उद्धरण
Beneficial microbes
2020
22 उद्धरण
Arquivos de gastroenterologia
2020
7 उद्धरण
Alimentary pharmacology & …
2019
59 उद्धरण
Probiotics and antimicrobial …
2019
43 उद्धरण
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 उद्धरण
Nutrients
2018
28 उद्धरण
The Turkish journal …
2017
29 उद्धरण
Pediatric gastroenterology, hepatology …
2017
27 उद्धरण
Frontiers in neuroscience
2017
14 उद्धरण
Korean journal for …
2017
7 उद्धरण
The Turkish journal …
2016
63 उद्धरण
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 उद्धरण
The American journal …
2014
284 उद्धरण
Nutrition journal
2014
75 उद्धरण
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Meta-Analysis
World journal of …
2013
111 उद्धरण
Arquivos de gastroenterologia
2013
49 उद्धरण
Georgian medical news
2013
World journal of …
2012
55 उद्धरण
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'.
Other
Nutrition journal
2012
51 उद्धरण
Scandinavian journal of …
2011
187 उद्धरण
Journal of clinical …
2011
163 उद्धरण
Pediatrics
2011
101 उद्धरण
Systematic review of randomised controlled trials: probiotics for functional constipation.
Systematic Review
World journal of …
2010
276 उद्धरण
Alimentary pharmacology & …
2009
333 उद्धरण
BMC pediatrics
2009
46 उद्धरण
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
RCT
World journal of …
2008
163 उद्धरण
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 1-10 billion CFU/day
- immunesupport:
- 5-10 billion CFU/day
- constipationsupport:
- 17.2 billion CFU/day (HN019 strain, optimal dose)
अधिकतम सीमा: Well-tolerated up to 17.2 billion CFU/day in clinical trials
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | 8 weeks | Neutral | -- |
| None | 4 weeks | Positive | 67 |
| None | 12 weeks | Positive | 35 |
| None | -- | Positive | -- |
| 1e6 CFU/mL | -- | Positive | 35 |
| 0.5 mL daily for 14 days | 2 weeks | Positive | 128 |
| None | 2 weeks | Negative | 117 |
| 10 g | 4 weeks | Positive | -- |
सेवन का सर्वोत्तम समय: With or without food; morning dosing may be optimal for transit effects
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
ज्ञात अंतःक्रियाएँ
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
सहनीय अधिकतम सेवन: Well-tolerated up to 17.2 billion CFU/day in clinical trials
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Bifidobacterium lactis help with Chronic Constipation?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium lactis should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium lactis?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Chronic Constipation
References
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FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।