Bifidobacterium lactis cho Chronic Constipation
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
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B
Kết luận
Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
Key Study Findings
Randomized Controlled Trial
8 weeks
Double-blind
Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …
Dose: None
so với: Placebo
Outcome: Complete spontaneous bowel movements (CSBMs)
Hiệu quả: None
None
Đối tượng nghiên cứu: Adults with functional constipation (Rome III)
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
so với: Placebo
Outcome: Weekly spontaneous bowel movements
Hiệu quả: 4.94 vs 3.00 (P<0.001)
P<0.001
Đối tượng nghiên cứu: Older adults >=60 with functional constipation (Rome IV)
Randomized Controlled Trial
n=35
12 weeks
Double-blind
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …
Dose: None
so với: Placebo
Outcome: Gut barrier function (zonulin levels)
Hiệu quả: Zonulin -19.5 ng/mL at week 16
p=0.0002 wk16; p=0.0053 grp
Đối tượng nghiên cứu: IBS without constipation patients
Review
An update on probiotics in paediatrics.
Dose: None
so với: None
Outcome: GI disorder outcomes in paediatrics
Hiệu quả: None
None
Đối tượng nghiên cứu: Paediatric patients with GI disorders
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
so với: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
Hiệu quả: None
<0.001
Đối tượng nghiên cứu: IBS patients (28) and asymptomatic controls (7)
Randomized Controlled Trial
n=128
2 weeks
Double-blind
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
Dose: 0.5 mL daily for 14 days
so với: Placebo
Outcome: Fever duration (days)
Hiệu quả: RR 0.64 (95% CI 0.51-0.80)
None
Đối tượng nghiên cứu: Children 28 days-4 years with fever and URTI
Key Statistics
4
Nghiên cứu
600
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
JAMA network open
2025
13 trích dẫn
Nutrients
2025
7 trích dẫn
International journal of …
2025
4 trích dẫn
Molecular nutrition & …
2025
2 trích dẫn
The journal of …
2025
Current opinion in …
2025
JAMA network open
2024
9 trích dẫn
European journal of …
2024
9 trích dẫn
Gut microbes
2023
143 trích dẫn
Journal of clinical …
2023
9 trích dẫn
Clinical nutrition (Edinburgh, …
2022
42 trích dẫn
Frontiers in nutrition
2022
24 trích dẫn
Frontiers in nutrition
2022
22 trích dẫn
Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models.
Other
PloS one
2022
21 trích dẫn
Medicine
2022
14 trích dẫn
Frontiers in microbiology
2022
4 trích dẫn
Medicine
2021
8 trích dẫn
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Meta-Analysis
Clinical nutrition (Edinburgh, …
2020
94 trích dẫn
Beneficial microbes
2020
22 trích dẫn
Arquivos de gastroenterologia
2020
7 trích dẫn
Alimentary pharmacology & …
2019
59 trích dẫn
Probiotics and antimicrobial …
2019
43 trích dẫn
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 trích dẫn
Nutrients
2018
28 trích dẫn
The Turkish journal …
2017
29 trích dẫn
Pediatric gastroenterology, hepatology …
2017
27 trích dẫn
Frontiers in neuroscience
2017
14 trích dẫn
Korean journal for …
2017
7 trích dẫn
The Turkish journal …
2016
63 trích dẫn
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 trích dẫn
The American journal …
2014
284 trích dẫn
Nutrition journal
2014
75 trích dẫn
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Meta-Analysis
World journal of …
2013
111 trích dẫn
Arquivos de gastroenterologia
2013
49 trích dẫn
Georgian medical news
2013
World journal of …
2012
55 trích dẫn
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'.
Other
Nutrition journal
2012
51 trích dẫn
Scandinavian journal of …
2011
187 trích dẫn
Journal of clinical …
2011
163 trích dẫn
Pediatrics
2011
101 trích dẫn
Systematic review of randomised controlled trials: probiotics for functional constipation.
Systematic Review
World journal of …
2010
276 trích dẫn
Alimentary pharmacology & …
2009
333 trích dẫn
BMC pediatrics
2009
46 trích dẫn
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
RCT
World journal of …
2008
163 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 1-10 billion CFU/day
- immunesupport:
- 5-10 billion CFU/day
- constipationsupport:
- 17.2 billion CFU/day (HN019 strain, optimal dose)
Giới hạn trên: Well-tolerated up to 17.2 billion CFU/day in clinical trials
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | 8 weeks | Neutral | -- |
| None | 4 weeks | Positive | 67 |
| None | 12 weeks | Positive | 35 |
| None | -- | Positive | -- |
| 1e6 CFU/mL | -- | Positive | 35 |
| 0.5 mL daily for 14 days | 2 weeks | Positive | 128 |
| None | 2 weeks | Negative | 117 |
| 10 g | 4 weeks | Positive | -- |
Thời điểm dùng tốt nhất: With or without food; morning dosing may be optimal for transit effects
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
Tương tác đã biết
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
Mức hấp thụ tối đa cho phép: Well-tolerated up to 17.2 billion CFU/day in clinical trials
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Bifidobacterium lactis help with Chronic Constipation?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium lactis should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium lactis?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Chronic Constipation
References
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