Bifidobacterium lactis para Chronic Constipation
B Evidencia Al menos un ensayo aleatorizado lo respalda, con resultados mayoritariamente consistentes.Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
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B
Conclusión
Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
Key Study Findings
Randomized Controlled Trial
8 weeks
Double-blind
Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …
Dose: None
vs: Placebo
Outcome: Complete spontaneous bowel movements (CSBMs)
Efecto: None
None
Población: Adults with functional constipation (Rome III)
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
vs: Placebo
Outcome: Weekly spontaneous bowel movements
Efecto: 4.94 vs 3.00 (P<0.001)
P<0.001
Población: Older adults >=60 with functional constipation (Rome IV)
Randomized Controlled Trial
n=35
12 weeks
Double-blind
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …
Dose: None
vs: Placebo
Outcome: Gut barrier function (zonulin levels)
Efecto: Zonulin -19.5 ng/mL at week 16
p=0.0002 wk16; p=0.0053 grp
Población: IBS without constipation patients
Review
An update on probiotics in paediatrics.
Dose: None
vs: None
Outcome: GI disorder outcomes in paediatrics
Efecto: None
None
Población: Paediatric patients with GI disorders
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
vs: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
Efecto: None
<0.001
Población: IBS patients (28) and asymptomatic controls (7)
Randomized Controlled Trial
n=128
2 weeks
Double-blind
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
Dose: 0.5 mL daily for 14 days
vs: Placebo
Outcome: Fever duration (days)
Efecto: RR 0.64 (95% CI 0.51-0.80)
None
Población: Children 28 days-4 years with fever and URTI
Key Statistics
4
Estudios
600
Participantes
↑
Positive
B
Calificación
Referenced Papers
JAMA network open
2025
13 citas
Nutrients
2025
7 citas
International journal of …
2025
4 citas
Molecular nutrition & …
2025
2 citas
The journal of …
2025
Current opinion in …
2025
JAMA network open
2024
9 citas
European journal of …
2024
9 citas
Gut microbes
2023
143 citas
Journal of clinical …
2023
9 citas
Clinical nutrition (Edinburgh, …
2022
42 citas
Frontiers in nutrition
2022
24 citas
Frontiers in nutrition
2022
22 citas
Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models.
Other
PloS one
2022
21 citas
Medicine
2022
14 citas
Frontiers in microbiology
2022
4 citas
Medicine
2021
8 citas
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Meta-Analysis
Clinical nutrition (Edinburgh, …
2020
94 citas
Beneficial microbes
2020
22 citas
Arquivos de gastroenterologia
2020
7 citas
Alimentary pharmacology & …
2019
59 citas
Probiotics and antimicrobial …
2019
43 citas
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 citas
Nutrients
2018
28 citas
The Turkish journal …
2017
29 citas
Pediatric gastroenterology, hepatology …
2017
27 citas
Frontiers in neuroscience
2017
14 citas
Korean journal for …
2017
7 citas
The Turkish journal …
2016
63 citas
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 citas
The American journal …
2014
284 citas
Nutrition journal
2014
75 citas
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Meta-Analysis
World journal of …
2013
111 citas
Arquivos de gastroenterologia
2013
49 citas
Georgian medical news
2013
World journal of …
2012
55 citas
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'.
Other
Nutrition journal
2012
51 citas
Scandinavian journal of …
2011
187 citas
Journal of clinical …
2011
163 citas
Pediatrics
2011
101 citas
Systematic review of randomised controlled trials: probiotics for functional constipation.
Systematic Review
World journal of …
2010
276 citas
Alimentary pharmacology & …
2009
333 citas
BMC pediatrics
2009
46 citas
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
RCT
World journal of …
2008
163 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 1-10 billion CFU/day
- immunesupport:
- 5-10 billion CFU/day
- constipationsupport:
- 17.2 billion CFU/day (HN019 strain, optimal dose)
Límite superior: Well-tolerated up to 17.2 billion CFU/day in clinical trials
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | 8 weeks | Neutral | -- |
| None | 4 weeks | Positive | 67 |
| None | 12 weeks | Positive | 35 |
| None | -- | Positive | -- |
| 1e6 CFU/mL | -- | Positive | 35 |
| 0.5 mL daily for 14 days | 2 weeks | Positive | 128 |
| None | 2 weeks | Negative | 117 |
| 10 g | 4 weeks | Positive | -- |
Mejor momento para tomar: With or without food; morning dosing may be optimal for transit effects
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
Interacciones conocidas
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
Ingesta máxima tolerable: Well-tolerated up to 17.2 billion CFU/day in clinical trials
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Bifidobacterium lactis help with Chronic Constipation?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium lactis should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium lactis?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Chronic Constipation
References
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