Bifidobacterium lactis 관련 Chronic Constipation
BDose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
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B
결론
Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
Key Study Findings
Randomized Controlled Trial
8 weeks
Double-blind
Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …
Dose: None
vs: Placebo
Outcome: Complete spontaneous bowel movements (CSBMs)
효과: None
None
대상 집단: Adults with functional constipation (Rome III)
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
vs: Placebo
Outcome: Weekly spontaneous bowel movements
효과: 4.94 vs 3.00 (P<0.001)
P<0.001
대상 집단: Older adults >=60 with functional constipation (Rome IV)
Randomized Controlled Trial
n=35
12 weeks
Double-blind
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …
Dose: None
vs: Placebo
Outcome: Gut barrier function (zonulin levels)
효과: Zonulin -19.5 ng/mL at week 16
p=0.0002 wk16; p=0.0053 grp
대상 집단: IBS without constipation patients
Review
An update on probiotics in paediatrics.
Dose: None
vs: None
Outcome: GI disorder outcomes in paediatrics
효과: None
None
대상 집단: Paediatric patients with GI disorders
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
vs: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
효과: None
<0.001
대상 집단: IBS patients (28) and asymptomatic controls (7)
Randomized Controlled Trial
n=128
2 weeks
Double-blind
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
Dose: 0.5 mL daily for 14 days
vs: Placebo
Outcome: Fever duration (days)
효과: RR 0.64 (95% CI 0.51-0.80)
None
대상 집단: Children 28 days-4 years with fever and URTI
Key Statistics
4
연구
600
참여자
↑
Positive
B
등급
Referenced Papers
JAMA network open
2025
13 인용
Nutrients
2025
7 인용
International journal of …
2025
4 인용
Molecular nutrition & …
2025
2 인용
The journal of …
2025
Current opinion in …
2025
JAMA network open
2024
9 인용
European journal of …
2024
9 인용
Gut microbes
2023
143 인용
Journal of clinical …
2023
9 인용
Clinical nutrition (Edinburgh, …
2022
42 인용
Frontiers in nutrition
2022
24 인용
Frontiers in nutrition
2022
22 인용
Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models.
Other
PloS one
2022
21 인용
Medicine
2022
14 인용
Frontiers in microbiology
2022
4 인용
Medicine
2021
8 인용
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Meta-Analysis
Clinical nutrition (Edinburgh, …
2020
94 인용
Beneficial microbes
2020
22 인용
Arquivos de gastroenterologia
2020
7 인용
Alimentary pharmacology & …
2019
59 인용
Probiotics and antimicrobial …
2019
43 인용
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 인용
Nutrients
2018
28 인용
The Turkish journal …
2017
29 인용
Pediatric gastroenterology, hepatology …
2017
27 인용
Frontiers in neuroscience
2017
14 인용
Korean journal for …
2017
7 인용
The Turkish journal …
2016
63 인용
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 인용
The American journal …
2014
284 인용
Nutrition journal
2014
75 인용
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Meta-Analysis
World journal of …
2013
111 인용
Arquivos de gastroenterologia
2013
49 인용
Georgian medical news
2013
World journal of …
2012
55 인용
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'.
Other
Nutrition journal
2012
51 인용
Scandinavian journal of …
2011
187 인용
Journal of clinical …
2011
163 인용
Pediatrics
2011
101 인용
Systematic review of randomised controlled trials: probiotics for functional constipation.
Systematic Review
World journal of …
2010
276 인용
Alimentary pharmacology & …
2009
333 인용
BMC pediatrics
2009
46 인용
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
RCT
World journal of …
2008
163 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 1-10 billion CFU/day
- immunesupport:
- 5-10 billion CFU/day
- constipationsupport:
- 17.2 billion CFU/day (HN019 strain, optimal dose)
상한량: Well-tolerated up to 17.2 billion CFU/day in clinical trials
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | 8 weeks | Neutral | -- |
| None | 4 weeks | Positive | 67 |
| None | 12 weeks | Positive | 35 |
| None | -- | Positive | -- |
| 1e6 CFU/mL | -- | Positive | 35 |
| 0.5 mL daily for 14 days | 2 weeks | Positive | 128 |
| None | 2 weeks | Negative | 117 |
| 10 g | 4 weeks | Positive | -- |
권장 복용 시간: With or without food; morning dosing may be optimal for transit effects
Safety & Side Effects
보고된 부작용
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
알려진 상호작용
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
일일 최대 섭취 허용량: Well-tolerated up to 17.2 billion CFU/day in clinical trials
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Bifidobacterium lactis help with Chronic Constipation?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium lactis should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium lactis?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Chronic Constipation
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