Bifidobacterium lactis لـ Chronic Constipation
BDose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
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B
الخلاصة
Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
Key Study Findings
Randomized Controlled Trial
8 weeks
Double-blind
Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …
Dose: None
مقابل: Placebo
Outcome: Complete spontaneous bowel movements (CSBMs)
التأثير: None
None
المجتمع المدروس: Adults with functional constipation (Rome III)
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
مقابل: Placebo
Outcome: Weekly spontaneous bowel movements
التأثير: 4.94 vs 3.00 (P<0.001)
P<0.001
المجتمع المدروس: Older adults >=60 with functional constipation (Rome IV)
Randomized Controlled Trial
n=35
12 weeks
Double-blind
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …
Dose: None
مقابل: Placebo
Outcome: Gut barrier function (zonulin levels)
التأثير: Zonulin -19.5 ng/mL at week 16
p=0.0002 wk16; p=0.0053 grp
المجتمع المدروس: IBS without constipation patients
Review
An update on probiotics in paediatrics.
Dose: None
مقابل: None
Outcome: GI disorder outcomes in paediatrics
التأثير: None
None
المجتمع المدروس: Paediatric patients with GI disorders
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
مقابل: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
التأثير: None
<0.001
المجتمع المدروس: IBS patients (28) and asymptomatic controls (7)
Randomized Controlled Trial
n=128
2 weeks
Double-blind
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
Dose: 0.5 mL daily for 14 days
مقابل: Placebo
Outcome: Fever duration (days)
التأثير: RR 0.64 (95% CI 0.51-0.80)
None
المجتمع المدروس: Children 28 days-4 years with fever and URTI
Key Statistics
4
الدراسات
600
المشاركون
↑
Positive
B
التقييم
Referenced Papers
JAMA network open
2025
13 اقتباسات
Nutrients
2025
7 اقتباسات
International journal of …
2025
4 اقتباسات
Molecular nutrition & …
2025
2 اقتباسات
The journal of …
2025
Current opinion in …
2025
JAMA network open
2024
9 اقتباسات
European journal of …
2024
9 اقتباسات
Gut microbes
2023
143 اقتباسات
Journal of clinical …
2023
9 اقتباسات
Clinical nutrition (Edinburgh, …
2022
42 اقتباسات
Frontiers in nutrition
2022
24 اقتباسات
Frontiers in nutrition
2022
22 اقتباسات
Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models.
Other
PloS one
2022
21 اقتباسات
Medicine
2022
14 اقتباسات
Frontiers in microbiology
2022
4 اقتباسات
Medicine
2021
8 اقتباسات
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Meta-Analysis
Clinical nutrition (Edinburgh, …
2020
94 اقتباسات
Beneficial microbes
2020
22 اقتباسات
Arquivos de gastroenterologia
2020
7 اقتباسات
Alimentary pharmacology & …
2019
59 اقتباسات
Probiotics and antimicrobial …
2019
43 اقتباسات
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 اقتباسات
Nutrients
2018
28 اقتباسات
The Turkish journal …
2017
29 اقتباسات
Pediatric gastroenterology, hepatology …
2017
27 اقتباسات
Frontiers in neuroscience
2017
14 اقتباسات
Korean journal for …
2017
7 اقتباسات
The Turkish journal …
2016
63 اقتباسات
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 اقتباسات
The American journal …
2014
284 اقتباسات
Nutrition journal
2014
75 اقتباسات
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Meta-Analysis
World journal of …
2013
111 اقتباسات
Arquivos de gastroenterologia
2013
49 اقتباسات
Georgian medical news
2013
World journal of …
2012
55 اقتباسات
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'.
Other
Nutrition journal
2012
51 اقتباسات
Scandinavian journal of …
2011
187 اقتباسات
Journal of clinical …
2011
163 اقتباسات
Pediatrics
2011
101 اقتباسات
Systematic review of randomised controlled trials: probiotics for functional constipation.
Systematic Review
World journal of …
2010
276 اقتباسات
Alimentary pharmacology & …
2009
333 اقتباسات
BMC pediatrics
2009
46 اقتباسات
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
RCT
World journal of …
2008
163 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1-10 billion CFU/day
- immunesupport:
- 5-10 billion CFU/day
- constipationsupport:
- 17.2 billion CFU/day (HN019 strain, optimal dose)
الحد الأعلى: Well-tolerated up to 17.2 billion CFU/day in clinical trials
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | 8 weeks | Neutral | -- |
| None | 4 weeks | Positive | 67 |
| None | 12 weeks | Positive | 35 |
| None | -- | Positive | -- |
| 1e6 CFU/mL | -- | Positive | 35 |
| 0.5 mL daily for 14 days | 2 weeks | Positive | 128 |
| None | 2 weeks | Negative | 117 |
| 10 g | 4 weeks | Positive | -- |
أفضل وقت للتناول: With or without food; morning dosing may be optimal for transit effects
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
التفاعلات المعروفة
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
الحد الأقصى المسموح به: Well-tolerated up to 17.2 billion CFU/day in clinical trials
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Bifidobacterium lactis help with Chronic Constipation?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium lactis should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium lactis?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Chronic Constipation
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.