Bifidobacterium lactis için Chronic Constipation

Q: Does Bifidobacterium lactis help with Chronic Constipation?

Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).

Q: How much Bifidobacterium lactis should I take for Chronic Constipation?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Bifidobacterium lactis?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.

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Sonuç

Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.

Key Study Findings

Randomized Controlled Trial 8 weeks Double-blind

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …

Dose: None vs: Placebo Outcome: Complete spontaneous bowel movements (CSBMs) Etki: None None

Popülasyon: Adults with functional constipation (Rome III)

Randomized Controlled Trial n=67 4 weeks Double-blind

Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …

Dose: None vs: Placebo Outcome: Weekly spontaneous bowel movements Etki: 4.94 vs 3.00 (P<0.001) P<0.001

Popülasyon: Older adults >=60 with functional constipation (Rome IV)

Randomized Controlled Trial n=35 12 weeks Double-blind

Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …

Dose: None vs: Placebo Outcome: Gut barrier function (zonulin levels) Etki: Zonulin -19.5 ng/mL at week 16 p=0.0002 wk16; p=0.0053 grp

Popülasyon: IBS without constipation patients

Review

An update on probiotics in paediatrics.

Dose: None vs: None Outcome: GI disorder outcomes in paediatrics Etki: None None

Popülasyon: Paediatric patients with GI disorders

In Vitro n=35

A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …

Dose: 1e6 CFU/mL vs: IBS supernatants without probiotic Outcome: Caco-2 paracellular permeability Etki: None <0.001

Popülasyon: IBS patients (28) and asymptomatic controls (7)

Randomized Controlled Trial n=128 2 weeks Double-blind

Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.

Dose: 0.5 mL daily for 14 days vs: Placebo Outcome: Fever duration (days) Etki: RR 0.64 (95% CI 0.51-0.80) None

Popülasyon: Children 28 days-4 years with fever and URTI

Key Statistics

Çalışmalar

600

Katılımcılar

↑

Positive

Derece

Referenced Papers

Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial. RCT

JAMA network open 2025 13 atıf

Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results … RCT

Nutrients 2025 7 atıf

A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536 Counteracts the Increase … Other

International journal of … 2025 4 atıf

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial. RCT

Molecular nutrition & … 2025 2 atıf

Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, … RCT

The journal of … 2025

An update on probiotics in paediatrics. Other

Current opinion in … 2025

Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial. RCT

JAMA network open 2024 9 atıf

Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention … RCT

European journal of … 2024 9 atıf

Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. RCT

Gut microbes 2023 143 atıf

The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in Adult Patients with Irritable Bowel … Other

Journal of clinical … 2023 9 atıf

Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis

Clinical nutrition (Edinburgh, … 2022 42 atıf

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice. Other

Frontiers in nutrition 2022 24 atıf

In vitro Study of Bifidobacterium lactis BL-99 With Fructooligosaccharide Synbiotics Effected on the Intestinal Microbiota. Other

Frontiers in nutrition 2022 22 atıf

Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models. Other

PloS one 2022 21 atıf

The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. RCT

Medicine 2022 14 atıf

Positive effect of Bifidobacterium animalis subsp. lactis VHProbi YB11 in improving gastrointestinal movement of mice having constipation. Other

Frontiers in microbiology 2022 4 atıf

The effect of probiotics on functional constipation in adults: Double-blind, randomized, placebo-controlled study. Other

Medicine 2021 8 atıf

Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Meta-Analysis

Clinical nutrition (Edinburgh, … 2020 94 atıf

A combination of three probiotic strains for treatment of acute diarrhoea in hospitalised children: an open label, randomised controlled trial. RCT

Beneficial microbes 2020 22 atıf

EFFECTS OF SYNBIOTIC SUPPLEMENTATION ON GUT FUNCTIONING AND SYSTEMIC INFLAMMATION OF COMMUNITY-DWELLING ELDERS - SECONDARY ANALYSES FROM A RANDOMIZED CLINICAL … RCT

Arquivos de gastroenterologia 2020 7 atıf

Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in … RCT

Alimentary pharmacology & … 2019 59 atıf

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 atıf

Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. Systematic Review

Journal of clinical … 2018 34 atıf

Effects of Synbiotics among Constipated Adults in Serdang, Selangor, Malaysia-A Randomised, Double-Blind, Placebo-Controlled Trial. RCT

Nutrients 2018 28 atıf

Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. RCT

The Turkish journal … 2017 29 atıf

Safety of a New Synbiotic Starter Formula. Other

Pediatric gastroenterology, hepatology … 2017 27 atıf

Promotility Action of the Probiotic Bifidobacterium lactis HN019 Extract Compared with Prucalopride in Isolated Rat Large Intestine. Other

Frontiers in neuroscience 2017 14 atıf

Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Other

Korean journal for … 2017 7 atıf

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. RCT

The Turkish journal … 2016 63 atıf

The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Systematic Review

Paediatric drugs 2015 122 atıf

The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Meta-Analysis

The American journal … 2014 284 atıf

Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. RCT

Nutrition journal 2014 75 atıf

Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials. Meta-Analysis

World journal of … 2013 111 atıf

Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis bi-07) in improving symptoms of constipation. RCT

Arquivos de gastroenterologia 2013 49 atıf

[Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants]. RCT

Georgian medical news 2013

Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis. RCT

World journal of … 2012 55 atıf

Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Other

Nutrition journal 2012 51 atıf

Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. RCT

Scandinavian journal of … 2011 187 atıf

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional … RCT

Journal of clinical … 2011 163 atıf

Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial. RCT

Pediatrics 2011 101 atıf

Systematic review of randomised controlled trials: probiotics for functional constipation. Systematic Review

World journal of … 2010 276 atıf

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit … RCT

Alimentary pharmacology & … 2009 333 atıf

Effect of the consumption of a fermented dairy product containing Bifidobacterium lactis DN-173 010 on constipation in childhood: a multicentre … RCT

BMC pediatrics 2009 46 atıf

Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. RCT

World journal of … 2008 163 atıf

Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. RCT

The journal of … 2007

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

general:: 1-10 billion CFU/day
immunesupport:: 5-10 billion CFU/day
constipationsupport:: 17.2 billion CFU/day (HN019 strain, optimal dose)

Üst sınır: Well-tolerated up to 17.2 billion CFU/day in clinical trials

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
None	8 weeks	Neutral	--
None	4 weeks	Positive	67
None	12 weeks	Positive	35
None	--	Positive	--
1e6 CFU/mL	--	Positive	35
0.5 mL daily for 14 days	2 weeks	Positive	128
None	2 weeks	Negative	117
10 g	4 weeks	Positive	--

En iyi alım zamanı: With or without food; morning dosing may be optimal for transit effects

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Mild gas and bloating during initial use
⚠ Occasional abdominal discomfort
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

Bilinen Etkileşimler

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (use with caution in immunocompromised patients)

Tolere edilebilir üst alım: Well-tolerated up to 17.2 billion CFU/day in clinical trials

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Bifidobacterium lactis help with Chronic Constipation?

Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).

How much Bifidobacterium lactis should I take for Chronic Constipation?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium lactis?

Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

Şu durum için diğer içerikler: Chronic Constipation

Psyllium Husk A Inulin B Fructooligosaccharides (FOS) C

Hızlı Değerlendirme

Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.

Evidence Strength72%

High confidence

Çalışma Dağılımı

RCT (25)Meta (4)Other (0)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Chronic Constipation

Daha Fazla Bilgi

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