What is the recommended dosage for Vitamin A?

General: 700-900 mcg RAE/day (RDA for adults); Gut Barrier Support: 900 mcg RAE/day from mixed sources; Deficiency Correction: 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)

What are the side effects of Vitamin A?

Potential side effects include: Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess.

What is vitamin A and how does it work for gut health?

Vitamin A is a fat-soluble vitamin essential for maintaining the integrity of mucosal surfaces throughout the body, including the intestinal lining. It supports the differentiation and function of epithelial cells that form the gut barrier, and plays a critical role in mucosal immune responses, including the production of secretory IgA. Vitamin A deficiency is associated with increased intestinal permeability and susceptibility to gastrointestinal infections.

What is the recommended dosage of vitamin A for gut health?

The recommended daily allowance is 900 mcg RAE (3,000 IU) for adult men and 700 mcg RAE (2,333 IU) for adult women. For gut health support, supplemental doses used in studies range from 5,000-10,000 IU per day. Beta-carotene (provitamin A) is a safer alternative at 15-30 mg per day, as the body converts it to vitamin A as needed, reducing toxicity risk.

Are there side effects or interactions with vitamin A?

Preformed vitamin A (retinol) can be toxic at high doses, causing nausea, headache, liver damage, and birth defects in pregnancy. The tolerable upper intake level is 3,000 mcg RAE (10,000 IU) per day for adults. Vitamin A may interact with retinoid medications (isotretinoin, tretinoin), warfarin, and hepatotoxic drugs. Pregnant women should not exceed the RDA without medical supervision.

Vitamin A
Vitamin A

vitamin

Aussi connu sous le nom de: Retinol, Retinyl Palmitate, Beta-Carotene (provitamin A), Retinoic Acid

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About

La vitamine A joue un rôle essentiel dans le maintien de la différenciation et du renouvellement des cellules épithéliales intestinales par la signalisation de l'acide rétinoïque. Elle soutient la production de mucus par les cellules caliciformes, composante clé de la barrière intestinale, et est nécessaire au transport des IgA sécrétoires à travers les surfaces muqueuses. Des recherches suggèrent que la vitamine A soutient l'intégrité de la barrière intestinale et la défense immunitaire muqueuse, en particulier dans les populations présentant une carence.

How It Works

Maintains intestinal epithelial cell differentiation and turnover via retinoic acid signaling through RAR/RXR nuclear receptors; supports goblet cell mucus production forming the protective mucus layer; required for secretory IgA transport across mucosal surfaces; modulates Th17/Treg balance in gut-associated lymphoid tissue (GALT).

Evidence For Conditions

Pathologie	Note	Études	Participants
Increased Intestinal Permeability (Leaky Gut)	C	3	250	Voir →
Acute Diarrhea	D	3	500	Voir →

Side Effects

Hepatotoxicity at chronic high doses of preformed vitamin A
Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
Nausea, headache, and dizziness
Bone density reduction with long-term excess

Drug & Supplement Interactions

Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
Orlistat (reduces absorption of fat-soluble vitamins)
Alcohol (increases hepatotoxicity risk of vitamin A)
Tetracycline antibiotics (increased risk of intracranial pressure)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Vitamin D

En bref

Posologie: General: 700-900 mcg RAE/day (RDA for adults); Gut_Barrier_Support: 900 mcg RAE/day from mixed sources; Deficiency_Correction: 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
Formes: capsule softgel liquid cod liver oil
Sources naturelles: Liver (highest preformed source), Sweet potatoes, Carrots, Spinach, Kale, Eggs, Cod liver oil
Limite supérieure: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
Meilleur moment: With meals containing fat for better absorption

Synthèse des preuves

Increased Intestinal Permeability (Leaky Gut) C

Acute Diarrhea D

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