Lactobacillus plantarum 用于 Irritable Bowel Syndrome (IBS)

Q: Does Lactobacillus plantarum help with Irritable Bowel Syndrome (IBS)?

Based on 5 studies with 800 participants, there is moderate evidence from clinical studies that Lactobacillus plantarum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

Q: How much Lactobacillus plantarum should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus plantarum?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Histamine-related symptoms in sensitive individuals (histamine-producing species), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus plantarum and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.

Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.

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结论

Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.

Key Study Findings

Meta-Analysis n=3154

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …

Dose: None vs: placebo Outcome: quality of life, depression, and anxiety in IBS … 效果: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

研究人群: patients with irritable bowel syndrome

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms 效果: None None

研究人群: patients with IBS from 32 RCTs evaluating 10 probiotic strains

Other n=25 4 weeks

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …

Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 vs: phosphate-buffered saline (PBS) Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores) 效果: None p<0.05

研究人群: female rats with water avoidance stress-induced IBS-D model

Other n=1098 8 weeks Open-label

A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of …

Dose: None vs: None (single-arm open-label) Outcome: Treatment success for abdominal pain and bloating 效果: 73% pain, 81.9% bloating success at T1 <0.001

研究人群: IBS patients from 52 Italian gastroenterologists

Other

Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating …

Dose: 1e9 CFU/day + GOS 10 g/L vs: IBS model mice without synbiotic Outcome: IBS symptoms and colonic dysfunction 效果: None <0.05

研究人群: C. rodentium + WAS IBS mouse model

Randomized Controlled Trial n=61 12 weeks Double-blind

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …

Dose: None vs: Placebo Outcome: IBS-SSS (100-point reduction) 效果: 45% active vs 33% placebo (P=0.42) P=0.42

研究人群: IBD patients with IBS symptoms in remission

Key Statistics

研究数量

800

受试者

↑

Positive

等级

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review … Meta-Analysis

European journal of … 2026

Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an … Other

Journal of the … 2026

Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating Mast Cell Hyperactivation. Other

Nutrients 2025 6 次引用

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel diseases in absence of inflammation … Other

World journal of … 2025 2 次引用

Synergistic Modulation of the Gut-Brain-Immune Axis by a Dual Lactobacillus Combination in a Murine IBS Model. Other

Journal of microbiology … 2025 1 次引用

A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of irritable bowel syndrome in adults. Other

Beneficial microbes 2025

Lactobacillus plantarum AR495 improves colonic transport hyperactivity in irritable bowel syndrome through tryptophan metabolism. Other

Food & function 2024 14 次引用

Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Other

Minerva gastroenterology 2024 4 次引用

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 次引用

ReFerm®: a postbiotic fermented oat gruel composition is reducing mast cell degranulation in the colon of patients with irritable bowel … Other

Frontiers in medicine 2024 2 次引用

Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact. Other

Journal of applied … 2024 1 次引用

Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis. Meta-Analysis

Gastroenterology 2023 75 次引用

Antibiotics and Probiotics for Irritable Bowel Syndrome. Review

Drugs 2023 21 次引用

Kimchi improves irritable bowel syndrome: results of a randomized, double-blind placebo-controlled study. Other

Food & nutrition … 2022 26 次引用

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 次引用

Effect of Oral Intake of Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) on Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. RCT

Nutrients 2022 20 次引用

A postbiotic fermented oat gruel may have a beneficial effect on the colonic mucosal barrier in patients with irritable bowel … Other

Frontiers in nutrition 2022 13 次引用

Role of Lactobacillus plantarum 299v versus Placebo in symptomatic improvement of irritable bowel syndrome patients. RCT

JPMA. The Journal … 2022 6 次引用

Lactiplantibacillus plantarum 299v (LP299V®): three decades of research. Review

Beneficial microbes 2021 69 次引用

Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Regulation and Gut Microbiota Modulation: A Double-Blind, Randomized, Placebo-Controlled Study. RCT

Frontiers in immunology 2021 67 次引用

Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome. RCT

European journal of … 2021 49 次引用

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Review

Microorganisms 2021 47 次引用

Combination of a Probiotic and an Antispasmodic Increases Quality of Life and Reduces Symptoms in Patients with Irritable Bowel Syndrome: … RCT

Digestive diseases (Basel, … 2021 28 次引用

Evidence from comparative genomic analyses indicating that Lactobacillus-mediated irritable bowel syndrome alleviation is mediated by conjugated linoleic acid synthesis. Other

Food & function 2021 21 次引用

Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Other

Frontiers in pain … 2021 15 次引用

Probiotics in irritable bowel syndrome - is the quest for the right strain over? Rapid review of existing guidelines and … Review

Przeglad gastroenterologiczny 2021 14 次引用

The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases. Review

Central-European journal of … 2020 38 次引用

Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study. RCT

The primary care … 2020 32 次引用

The use of Lactobacillus plantarum 299v (DSM 9843) in cancer patients receiving home enteral nutrition - study protocol for a … Other

Nutrition journal 2020 28 次引用

Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in … RCT

European review for … 2020 21 次引用

Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut-Brain Axis. Other

Probiotics and antimicrobial … 2020 21 次引用

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 次引用

Technological Methods for Reducing the Content of Fructan in Wheat Bread. Other

Foods (Basel, Switzerland) 2019 21 次引用

Abincol® (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01), an oral nutraceutical, pragmatic use in patients with … Other

Acta bio-medica : … 2019 6 次引用

Lacto-fermented sauerkraut improves symptoms in IBS patients independent of product pasteurisation - a pilot study. RCT

Food & function 2018 77 次引用

Probiotics Ameliorate Stool Consistency in Patients with Chronic Constipation: A Randomized, Double-Blind, Placebo-Controlled Study. RCT

Digestive diseases and … 2018 57 次引用

Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect. Other

Applied microbiology and … 2015 107 次引用

Randomized clinical trial: effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome. RCT

Nutrition (Burbank, Los … 2014 64 次引用

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 次引用

A meta-analysis of probiotic efficacy for gastrointestinal diseases. Meta-Analysis

PloS one 2012 445 次引用

Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. RCT

World journal of … 2012 277 次引用

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 次引用

[Irritable bowel syndrome--irritable bowel or irritable mind?]. Review

Polski merkuriusz lekarski … 2012 8 次引用

Treatment of irritable bowel syndrome with probiotics. An etiopathogenic approach at last? Review

Revista espanola de … 2009 1 次引用

Use of diet and probiotic therapy in the irritable bowel syndrome: analysis of the literature. Review

Journal of clinical … 2005 54 次引用

[Probiotics as therapeutic agents in irritable bowel syndrome]. Meta-Analysis

Zeitschrift fur Gastroenterologie 2005 17 次引用

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 次引用

An in vitro assessment of the effects of broad-spectrum antibiotics on the human gut microflora and concomitant isolation of a … Other

Anaerobe 2004 40 次引用

Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable bowel syndrome. Other

Digestive diseases and … 2002 250 次引用

Irritable Bowel Syndrome. Other

Current treatment options … 2002 5 次引用

A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. RCT

European journal of … 2001 518 次引用

Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. RCT

The American journal … 2000 648 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 10-20 billion CFU/day
ibssupport:: 10 billion CFU/day (299v strain) for 4 weeks minimum

上限： Well-tolerated up to 20 billion CFU/day in clinical trials

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	3154
None	--	Positive	--
Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917	4 weeks	Positive	25
None	8 weeks	Positive	1098
1e9 CFU/day + GOS 10 g/L	--	Positive	--
None	12 weeks	Neutral	61
None	--	Positive	--
None	--	Positive	--

最佳服用时间： On an empty stomach or before meals

Safety & Side Effects

已报告的副作用

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Histamine-related symptoms in sensitive individuals (histamine-producing species)
⚠ Very rare: bacteremia in immunocompromised individuals

已知相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Histamine-intolerance medications (L. plantarum may produce biogenic amines)

可耐受最高摄入量： Well-tolerated up to 20 billion CFU/day in clinical trials

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Lactobacillus plantarum help with Irritable Bowel Syndrome (IBS)?

Based on 5 studies with 800 participants, there is moderate evidence from clinical studies that Lactobacillus plantarum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus plantarum should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus plantarum?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Histamine-related symptoms in sensitive individuals (histamine-producing species), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus plantarum and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Irritable Bowel Syndrome (IBS)

Peppermint Oil A Psyllium Husk B Lactobacillus rhamnosus GG B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B Galactooligosaccharides (GOS) B

快速结论

Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.

Evidence Strength72%

High confidence

研究分析

RCT (15)Meta (5)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Irritable Bowel Syndrome (IBS)

了解更多

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