Lactobacillus plantarum cho Irritable Bowel Syndrome (IBS)
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.
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B
Kết luận
Reduces abdominal pain and bloating in IBS. Multiple RCTs show significant improvement in global IBS symptom scores. Strain-specific evidence for 299v is relatively strong.
Key Study Findings
Meta-Analysis
n=3154
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …
Dose: None
so với: placebo
Outcome: quality of life, depression, and anxiety in IBS …
Hiệu quả: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression)
None
Đối tượng nghiên cứu: patients with irritable bowel syndrome
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
so với: placebo
Outcome: improvement in key IBS symptoms
Hiệu quả: None
None
Đối tượng nghiên cứu: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Other
n=25
4 weeks
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 …
Dose: Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917
so với: phosphate-buffered saline (PBS)
Outcome: visceral hypersensitivity (abdominal withdrawal reflex scores)
Hiệu quả: None
p<0.05
Đối tượng nghiên cứu: female rats with water avoidance stress-induced IBS-D model
Other
Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating …
Dose: 1e9 CFU/day + GOS 10 g/L
so với: IBS model mice without synbiotic
Outcome: IBS symptoms and colonic dysfunction
Hiệu quả: None
<0.05
Đối tượng nghiên cứu: C. rodentium + WAS IBS mouse model
Other
Synergistic Modulation of the Gut-Brain-Immune Axis by a Dual Lactobacillus Combination in a Murine IBS …
Dose: None
so với: Single-strain or vehicle control
Outcome: IBS-like symptoms in zymosan-induced mouse model
Hiệu quả: None
None
Đối tượng nghiên cứu: Zymosan-induced IBS mouse model
Randomized Controlled Trial
n=61
12 weeks
Double-blind
Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …
Dose: None
so với: Placebo
Outcome: IBS-SSS (100-point reduction)
Hiệu quả: 45% active vs 33% placebo (P=0.42)
P=0.42
Đối tượng nghiên cứu: IBD patients with IBS symptoms in remission
Key Statistics
5
Nghiên cứu
800
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
Journal of clinical …
2026
European journal of …
2026
Journal of the …
2026
Nutrients
2025
6 trích dẫn
World journal of …
2025
2 trích dẫn
Journal of microbiology …
2025
1 trích dẫn
Beneficial microbes
2025
Food & function
2024
14 trích dẫn
Minerva gastroenterology
2024
4 trích dẫn
Journal of neurogastroenterology …
2024
4 trích dẫn
Frontiers in medicine
2024
2 trích dẫn
Journal of applied …
2024
1 trích dẫn
Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
Meta-Analysis
Gastroenterology
2023
75 trích dẫn
Drugs
2023
21 trích dẫn
Food & nutrition …
2022
26 trích dẫn
Journal of neurogastroenterology …
2022
21 trích dẫn
Nutrients
2022
20 trích dẫn
Frontiers in nutrition
2022
13 trích dẫn
JPMA. The Journal …
2022
6 trích dẫn
Beneficial microbes
2021
69 trích dẫn
Frontiers in immunology
2021
67 trích dẫn
European journal of …
2021
49 trích dẫn
Microorganisms
2021
47 trích dẫn
Digestive diseases (Basel, …
2021
28 trích dẫn
Food & function
2021
21 trích dẫn
Frontiers in pain …
2021
15 trích dẫn
Przeglad gastroenterologiczny
2021
14 trích dẫn
Central-European journal of …
2020
38 trích dẫn
The primary care …
2020
32 trích dẫn
Nutrition journal
2020
28 trích dẫn
European review for …
2020
21 trích dẫn
Probiotics and antimicrobial …
2020
21 trích dẫn
Probiotics and antimicrobial …
2019
43 trích dẫn
Foods (Basel, Switzerland)
2019
21 trích dẫn
Acta bio-medica : …
2019
6 trích dẫn
Food & function
2018
77 trích dẫn
Digestive diseases and …
2018
57 trích dẫn
Applied microbiology and …
2015
107 trích dẫn
Nutrition (Burbank, Los …
2014
64 trích dẫn
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Meta-Analysis
Revista espanola de …
2013
102 trích dẫn
PloS one
2012
445 trích dẫn
World journal of …
2012
277 trích dẫn
Journal of clinical …
2012
207 trích dẫn
Polski merkuriusz lekarski …
2012
8 trích dẫn
Revista espanola de …
2009
1 trích dẫn
Use of diet and probiotic therapy in the irritable bowel syndrome: analysis of the literature.
Review
Journal of clinical …
2005
54 trích dẫn
Zeitschrift fur Gastroenterologie
2005
17 trích dẫn
Journal of clinical …
2004
205 trích dẫn
Anaerobe
2004
40 trích dẫn
Digestive diseases and …
2002
250 trích dẫn
Current treatment options …
2002
5 trích dẫn
European journal of …
2001
518 trích dẫn
The American journal …
2000
648 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day (299v strain) for 4 weeks minimum
Giới hạn trên: Well-tolerated up to 20 billion CFU/day in clinical trials
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | 3154 |
| None | -- | Positive | -- |
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| 1e9 CFU/day + GOS 10 g/L | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Neutral | 61 |
| None | 8 weeks | Positive | 1098 |
| 10 μg | 6 weeks | Positive | 246 |
Thời điểm dùng tốt nhất: On an empty stomach or before meals
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional loose stools
- ⚠ Histamine-related symptoms in sensitive individuals (histamine-producing species)
- ⚠ Very rare: bacteremia in immunocompromised individuals
Tương tác đã biết
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk in immunocompromised patients)
- ● Histamine-intolerance medications (L. plantarum may produce biogenic amines)
Mức hấp thụ tối đa cho phép: Well-tolerated up to 20 billion CFU/day in clinical trials
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Lactobacillus plantarum help with Irritable Bowel Syndrome (IBS)?
Based on 5 studies with 800 participants, there is moderate evidence from clinical studies that Lactobacillus plantarum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Lactobacillus plantarum should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus plantarum?
Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Histamine-related symptoms in sensitive individuals (histamine-producing species), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus plantarum and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Irritable Bowel Syndrome (IBS)
References
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