Berberine 用于 Gut Dysbiosis

Q: Does Berberine help with Gut Dysbiosis?

Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).

Q: How much Berberine should I take for Gut Dysbiosis?

Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Berberine?

Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Berberine and Gut Dysbiosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'ingredient\u003Dberberine\u0026condition\u003Dgut\u002Ddysbiosis'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

结论

Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.

Key Study Findings

In Vitro

Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal …

Dose: None vs: Sulfasalazine; DSS-induced UC mice Outcome: UC treatment efficacy 效果: Colon length 1.2x longer than sulfasalazine None

研究人群: DSS-induced UC murine model

Review

Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Review

Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Review

Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Other

Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.

Dose: None vs: Free berberine; DSS-induced UC model vs normal mice Outcome: DAI scores, inflammatory cytokines, gut microbiota 效果: None <0.01 (DAI); <0.05 (cytokines)

研究人群: DSS-induced UC mouse model (male KM mice)

Other

Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.

Dose: None vs: DSS-induced colitis + periodontitis mouse models Outcome: Periodontal destruction and myeloid cell generation 效果: None None

研究人群: DSS-induced colitis with periodontitis mouse model

Key Statistics

研究数量

100

受试者

↑

Positive

等级

Referenced Papers

Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives. Review

International journal of … 2025 15 次引用

Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal barrier and gut microbiota. Other

Colloids and surfaces. … 2025 11 次引用

Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver Disease. Review

Pharmaceuticals (Basel, Switzerland) 2025 8 次引用

Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent. Review

Pharmaceuticals (Basel, Switzerland) 2025 8 次引用

Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis. Other

Inflammatory bowel diseases 2025 2 次引用

Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles. Other

Pharmaceutics 2025 2 次引用

Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment. Other

Phytomedicine : international … 2025 2 次引用

Berberine alleviates metabolic dysfunction-associated steatohepatitis by enhancing the abundance of Akkermansia muciniphila. Other

The Journal of … 2025 1 次引用

Oxyberberine alleviates fructose-induced hyperuricemia by modulating purine metabolism and gut microbiota. Other

European journal of … 2025

Phellodendron bark extract and berberine chloride suppress microbiome dysbiosis in a saliva-derived in vitro microcosm biofilm model. Other

Archives of oral … 2025

The role of traditional Chinese medicine in modulating gut microbiota to alleviating insulin resistance in polycystic ovary syndrome. Review

Frontiers in nutrition 2025

Integration of microbiome, metabolomics and transcriptome for in-depth understanding of berberine attenuates AOM/DSS-induced colitis-associated colorectal cancer. Other

Biomedicine & pharmacotherapy … 2024 17 次引用

Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature. Systematic Review

International journal of … 2024 14 次引用

Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on … Other

Frontiers in pharmacology 2024 9 次引用

Berberine alleviates concanavalin A-induced autoimmune hepatitis in mice by modulating the gut microbiota. Other

Hepatology communications 2024 9 次引用

Total Alkaloids of Rhizoma Corydalis regulates gut microbiota and restores gut immune barrier to ameliorate cognitive dysfunction in diabetic rats. Other

Frontiers in microbiology 2024 6 次引用

Intestinal and hepatic benefits of BBR-EVO on DSS-induced experimental colitis in mice. Other

Frontiers in microbiology 2024 5 次引用

Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance. Review

Indian journal of … 2024 2 次引用

Colorectal cancer and gut microbiota studies in China. Review

Gut microbes 2023 108 次引用

Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism. Other

Biomedicine & pharmacotherapy … 2023 61 次引用

Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine. Other

International journal of … 2023 48 次引用

Role of herbal medicine and gut microbiota in the prevention and treatment of obesity. Review

Journal of ethnopharmacology 2023 29 次引用

Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. Other

Frontiers in pharmacology 2023 20 次引用

Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies. Meta-Analysis

International journal of … 2023 18 次引用

Alkaloids as Promising Agents for the Management of Insulin Resistance: A Review. Review

Current pharmaceutical design 2023 10 次引用

An in vitro study of the effects of Phellodendron bark extract and berberine chloride on periodontal pathogenic bacteria in the … Other

Journal of oral … 2023 10 次引用

Distinct Effects of Non-absorbed Agents Rifaximin and Berberine on the Microbiota-Gut-Brain Axis in Dysbiosis-induced Visceral Hypersensitivity in Rats. Other

Journal of neurogastroenterology … 2023 4 次引用

Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome. Review

Clinical and experimental … 2023 2 次引用

Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry. Review

Microorganisms 2022 212 次引用

Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. Other

Food & function 2022 83 次引用

Berberine suppresses colorectal cancer by regulation of Hedgehog signaling pathway activity and gut microbiota. Other

Phytomedicine : international … 2022 67 次引用

An oral pH-activated "nano-bomb" carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative … Other

Biomaterials science 2022 34 次引用

Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota. Other

Microbiology spectrum 2022 25 次引用

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in … Other

Brazilian journal of … 2022 12 次引用

Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent … Other

Pharmacological research 2021 186 次引用

Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Other

Pharmacological research 2021 147 次引用

Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation. Other

Acta pharmacologica Sinica 2021 63 次引用

Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. Other

Frontiers in pharmacology 2021 42 次引用

The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves' Disease Patients Through Regulating the Intestinal Microbiome. Other

Frontiers in immunology 2021 22 次引用

Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease. Other

Comprehensive Physiology 2021 21 次引用

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. Review

International journal of … 2021 20 次引用

Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases. Review

Pharmacological research 2020 65 次引用

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Systematic Review

Journal of integrative … 2020 33 次引用

Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions. Review

Pharmacological research 2019 166 次引用

Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids. Other

American journal of … 2019 117 次引用

Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Other

Biomedicine & pharmacotherapy … 2019 72 次引用

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice. Other

Scientific reports 2019 51 次引用

Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. Review

Pharmacological research 2019 31 次引用

Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis. Other

Science China. Life … 2018 17 次引用

Nutritional Management of Metabolic Endotoxemia: A Clinical Review. Review

Alternative therapies in … 2017 9 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 500-1,500 mg/day in divided doses
siboprotocol:: 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
giantimicrobial:: 500 mg twice daily

上限： Generally well-tolerated up to 1,500 mg/day in divided doses

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	6 weeks	Positive	--

最佳服用时间： With meals; divide doses throughout the day (do not take full daily dose at once)

Safety & Side Effects

已报告的副作用

⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
⚠ May cause uterine contractions (contraindicated in pregnancy)
⚠ Headache
⚠ Skin rash (rare)

已知相互作用

● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
● Anticoagulants (may have additive blood-thinning effects)
● Metformin (additive glucose-lowering effect; monitor closely)
● Macrolide antibiotics (berberine inhibits CYP3A4)

可耐受最高摄入量： Generally well-tolerated up to 1,500 mg/day in divided doses

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Berberine help with Gut Dysbiosis?

Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).

How much Berberine should I take for Gut Dysbiosis?

Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Berberine?

Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Berberine and Gut Dysbiosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Gut Dysbiosis

Inulin D Medium-Chain Triglycerides (MCT Oil) D

Berberine 用于其他健康状况

Acute Diarrhea C Small Intestinal Bacterial Overgrowth (SIBO) C

快速结论

Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.

Evidence Strength30%

Low confidence

研究分析

RCT (0)Meta (1)Other (1)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Gut Dysbiosis

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。