Berberine para Gut Dysbiosis
DPreclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
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D
Conclusión
Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
Key Study Findings
In Vitro
Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal …
Dose: None
vs: Sulfasalazine; DSS-induced UC mice
Outcome: UC treatment efficacy
Efecto: Colon length 1.2x longer than sulfasalazine
None
Población: DSS-induced UC murine model
Review
Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Review
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Review
Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Other
Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.
Dose: None
vs: Free berberine; DSS-induced UC model vs normal mice
Outcome: DAI scores, inflammatory cytokines, gut microbiota
Efecto: None
<0.01 (DAI); <0.05 (cytokines)
Población: DSS-induced UC mouse model (male KM mice)
Other
Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.
Dose: None
vs: DSS-induced colitis + periodontitis mouse models
Outcome: Periodontal destruction and myeloid cell generation
Efecto: None
None
Población: DSS-induced colitis with periodontitis mouse model
Key Statistics
2
Estudios
100
Participantes
↑
Positive
D
Calificación
Referenced Papers
International journal of …
2025
15 citas
Colloids and surfaces. …
2025
11 citas
Pharmaceuticals (Basel, Switzerland)
2025
8 citas
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Review
Pharmaceuticals (Basel, Switzerland)
2025
8 citas
Inflammatory bowel diseases
2025
2 citas
Pharmaceutics
2025
2 citas
Phytomedicine : international …
2025
2 citas
The Journal of …
2025
1 citas
European journal of …
2025
Archives of oral …
2025
Frontiers in nutrition
2025
Biomedicine & pharmacotherapy …
2024
17 citas
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature.
Systematic Review
International journal of …
2024
14 citas
Frontiers in pharmacology
2024
9 citas
Hepatology communications
2024
9 citas
Frontiers in microbiology
2024
6 citas
Frontiers in microbiology
2024
5 citas
Indian journal of …
2024
2 citas
Gut microbes
2023
108 citas
Biomedicine & pharmacotherapy …
2023
61 citas
International journal of …
2023
48 citas
Journal of ethnopharmacology
2023
29 citas
Frontiers in pharmacology
2023
20 citas
International journal of …
2023
18 citas
Current pharmaceutical design
2023
10 citas
Journal of oral …
2023
10 citas
Journal of neurogastroenterology …
2023
4 citas
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome.
Review
Clinical and experimental …
2023
2 citas
Microorganisms
2022
212 citas
Food & function
2022
83 citas
Phytomedicine : international …
2022
67 citas
Biomaterials science
2022
34 citas
Microbiology spectrum
2022
25 citas
Brazilian journal of …
2022
12 citas
Pharmacological research
2021
186 citas
Pharmacological research
2021
147 citas
Acta pharmacologica Sinica
2021
63 citas
Frontiers in pharmacology
2021
42 citas
Frontiers in immunology
2021
22 citas
Comprehensive Physiology
2021
21 citas
International journal of …
2021
20 citas
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 citas
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
Systematic Review
Journal of integrative …
2020
33 citas
Pharmacological research
2019
166 citas
American journal of …
2019
117 citas
Biomedicine & pharmacotherapy …
2019
72 citas
Scientific reports
2019
51 citas
Pharmacological research
2019
31 citas
Science China. Life …
2018
17 citas
Alternative therapies in …
2017
9 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 500-1,500 mg/day in divided doses
- siboprotocol:
- 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
- giantimicrobial:
- 500 mg twice daily
Límite superior: Generally well-tolerated up to 1,500 mg/day in divided doses
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 6 weeks | Positive | -- |
Mejor momento para tomar: With meals; divide doses throughout the day (do not take full daily dose at once)
Safety & Side Effects
Efectos secundarios reportados
- ⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- ⚠ May cause uterine contractions (contraindicated in pregnancy)
- ⚠ Headache
- ⚠ Skin rash (rare)
Interacciones conocidas
- ● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- ● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- ● Anticoagulants (may have additive blood-thinning effects)
- ● Metformin (additive glucose-lowering effect; monitor closely)
- ● Macrolide antibiotics (berberine inhibits CYP3A4)
Ingesta máxima tolerable: Generally well-tolerated up to 1,500 mg/day in divided doses
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Berberine help with Gut Dysbiosis?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).
How much Berberine should I take for Gut Dysbiosis?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Berberine?
Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Berberine and Gut Dysbiosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Gut Dysbiosis
Berberine para otras condiciones
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.