Berberine untuk Gut Dysbiosis
DPreclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
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D
Kesimpulan
Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
Key Study Findings
In Vitro
Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal …
Dose: None
vs: Sulfasalazine; DSS-induced UC mice
Outcome: UC treatment efficacy
Efek: Colon length 1.2x longer than sulfasalazine
None
Populasi: DSS-induced UC murine model
Review
Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Review
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Review
Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Other
Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.
Dose: None
vs: Free berberine; DSS-induced UC model vs normal mice
Outcome: DAI scores, inflammatory cytokines, gut microbiota
Efek: None
<0.01 (DAI); <0.05 (cytokines)
Populasi: DSS-induced UC mouse model (male KM mice)
Other
Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.
Dose: None
vs: DSS-induced colitis + periodontitis mouse models
Outcome: Periodontal destruction and myeloid cell generation
Efek: None
None
Populasi: DSS-induced colitis with periodontitis mouse model
Key Statistics
2
Studi
100
Peserta
↑
Positive
D
Peringkat
Referenced Papers
International journal of …
2025
15 sitasi
Colloids and surfaces. …
2025
11 sitasi
Pharmaceuticals (Basel, Switzerland)
2025
8 sitasi
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Review
Pharmaceuticals (Basel, Switzerland)
2025
8 sitasi
Inflammatory bowel diseases
2025
2 sitasi
Pharmaceutics
2025
2 sitasi
Phytomedicine : international …
2025
2 sitasi
The Journal of …
2025
1 sitasi
European journal of …
2025
Archives of oral …
2025
Frontiers in nutrition
2025
Biomedicine & pharmacotherapy …
2024
17 sitasi
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature.
Systematic Review
International journal of …
2024
14 sitasi
Frontiers in pharmacology
2024
9 sitasi
Hepatology communications
2024
9 sitasi
Frontiers in microbiology
2024
6 sitasi
Frontiers in microbiology
2024
5 sitasi
Indian journal of …
2024
2 sitasi
Gut microbes
2023
108 sitasi
Biomedicine & pharmacotherapy …
2023
61 sitasi
International journal of …
2023
48 sitasi
Journal of ethnopharmacology
2023
29 sitasi
Frontiers in pharmacology
2023
20 sitasi
International journal of …
2023
18 sitasi
Current pharmaceutical design
2023
10 sitasi
Journal of oral …
2023
10 sitasi
Journal of neurogastroenterology …
2023
4 sitasi
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome.
Review
Clinical and experimental …
2023
2 sitasi
Microorganisms
2022
212 sitasi
Food & function
2022
83 sitasi
Phytomedicine : international …
2022
67 sitasi
Biomaterials science
2022
34 sitasi
Microbiology spectrum
2022
25 sitasi
Brazilian journal of …
2022
12 sitasi
Pharmacological research
2021
186 sitasi
Pharmacological research
2021
147 sitasi
Acta pharmacologica Sinica
2021
63 sitasi
Frontiers in pharmacology
2021
42 sitasi
Frontiers in immunology
2021
22 sitasi
Comprehensive Physiology
2021
21 sitasi
International journal of …
2021
20 sitasi
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 sitasi
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
Systematic Review
Journal of integrative …
2020
33 sitasi
Pharmacological research
2019
166 sitasi
American journal of …
2019
117 sitasi
Biomedicine & pharmacotherapy …
2019
72 sitasi
Scientific reports
2019
51 sitasi
Pharmacological research
2019
31 sitasi
Science China. Life …
2018
17 sitasi
Alternative therapies in …
2017
9 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 500-1,500 mg/day in divided doses
- siboprotocol:
- 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
- giantimicrobial:
- 500 mg twice daily
Batas atas: Generally well-tolerated up to 1,500 mg/day in divided doses
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 6 weeks | Positive | -- |
Waktu terbaik diminum: With meals; divide doses throughout the day (do not take full daily dose at once)
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- ⚠ May cause uterine contractions (contraindicated in pregnancy)
- ⚠ Headache
- ⚠ Skin rash (rare)
Interaksi yang Diketahui
- ● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- ● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- ● Anticoagulants (may have additive blood-thinning effects)
- ● Metformin (additive glucose-lowering effect; monitor closely)
- ● Macrolide antibiotics (berberine inhibits CYP3A4)
Asupan atas yang dapat ditoleransi: Generally well-tolerated up to 1,500 mg/day in divided doses
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Berberine help with Gut Dysbiosis?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).
How much Berberine should I take for Gut Dysbiosis?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Berberine?
Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Berberine and Gut Dysbiosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Gut Dysbiosis
Berberine untuk kondisi lain
Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.