Berberine لـ Gut Dysbiosis
D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
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D
الخلاصة
Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.
Key Study Findings
In Vitro
Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal …
Dose: None
مقابل: Sulfasalazine; DSS-induced UC mice
Outcome: UC treatment efficacy
التأثير: Colon length 1.2x longer than sulfasalazine
None
المجتمع المدروس: DSS-induced UC murine model
Review
Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Other
Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.
Dose: None
مقابل: Free berberine; DSS-induced UC model vs normal mice
Outcome: DAI scores, inflammatory cytokines, gut microbiota
التأثير: None
<0.01 (DAI); <0.05 (cytokines)
المجتمع المدروس: DSS-induced UC mouse model (male KM mice)
Other
Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.
Dose: None
مقابل: DSS-induced colitis + periodontitis mouse models
Outcome: Periodontal destruction and myeloid cell generation
التأثير: None
None
المجتمع المدروس: DSS-induced colitis with periodontitis mouse model
Key Statistics
2
الدراسات
100
المشاركون
↑
Positive
D
التقييم
Referenced Papers
International journal of …
2025
15 اقتباسات
Colloids and surfaces. …
2025
11 اقتباسات
Pharmaceuticals (Basel, Switzerland)
2025
8 اقتباسات
Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.
Review
Pharmaceuticals (Basel, Switzerland)
2025
8 اقتباسات
Inflammatory bowel diseases
2025
2 اقتباسات
Pharmaceutics
2025
2 اقتباسات
Phytomedicine : international …
2025
2 اقتباسات
The Journal of …
2025
1 اقتباسات
European journal of …
2025
Archives of oral …
2025
Frontiers in nutrition
2025
Biomedicine & pharmacotherapy …
2024
17 اقتباسات
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature.
Systematic Review
International journal of …
2024
14 اقتباسات
Frontiers in pharmacology
2024
9 اقتباسات
Hepatology communications
2024
9 اقتباسات
Frontiers in microbiology
2024
6 اقتباسات
Frontiers in microbiology
2024
5 اقتباسات
Indian journal of …
2024
2 اقتباسات
Gut microbes
2023
108 اقتباسات
Biomedicine & pharmacotherapy …
2023
61 اقتباسات
International journal of …
2023
48 اقتباسات
Journal of ethnopharmacology
2023
29 اقتباسات
Frontiers in pharmacology
2023
20 اقتباسات
International journal of …
2023
18 اقتباسات
Current pharmaceutical design
2023
10 اقتباسات
Journal of oral …
2023
10 اقتباسات
Journal of neurogastroenterology …
2023
4 اقتباسات
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome.
Review
Clinical and experimental …
2023
2 اقتباسات
Microorganisms
2022
212 اقتباسات
Food & function
2022
83 اقتباسات
Phytomedicine : international …
2022
67 اقتباسات
Biomaterials science
2022
34 اقتباسات
Microbiology spectrum
2022
25 اقتباسات
Brazilian journal of …
2022
12 اقتباسات
Pharmacological research
2021
186 اقتباسات
Pharmacological research
2021
147 اقتباسات
Acta pharmacologica Sinica
2021
63 اقتباسات
Frontiers in pharmacology
2021
42 اقتباسات
Frontiers in immunology
2021
22 اقتباسات
Comprehensive Physiology
2021
21 اقتباسات
International journal of …
2021
20 اقتباسات
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 اقتباسات
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
Systematic Review
Journal of integrative …
2020
33 اقتباسات
Pharmacological research
2019
166 اقتباسات
American journal of …
2019
117 اقتباسات
Biomedicine & pharmacotherapy …
2019
72 اقتباسات
Scientific reports
2019
51 اقتباسات
Pharmacological research
2019
31 اقتباسات
Science China. Life …
2018
17 اقتباسات
Alternative therapies in …
2017
9 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 500-1,500 mg/day in divided doses
- siboprotocol:
- 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
- giantimicrobial:
- 500 mg twice daily
الحد الأعلى: Generally well-tolerated up to 1,500 mg/day in divided doses
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 6 weeks | Positive | -- |
أفضل وقت للتناول: With meals; divide doses throughout the day (do not take full daily dose at once)
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- ⚠ May cause uterine contractions (contraindicated in pregnancy)
- ⚠ Headache
- ⚠ Skin rash (rare)
التفاعلات المعروفة
- ● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- ● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- ● Anticoagulants (may have additive blood-thinning effects)
- ● Metformin (additive glucose-lowering effect; monitor closely)
- ● Macrolide antibiotics (berberine inhibits CYP3A4)
الحد الأقصى المسموح به: Generally well-tolerated up to 1,500 mg/day in divided doses
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Berberine help with Gut Dysbiosis?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).
How much Berberine should I take for Gut Dysbiosis?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Berberine?
Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Berberine and Gut Dysbiosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Gut Dysbiosis
Berberine لحالات أخرى
References
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