BerberineBerberine
herb
Berberine
Berberine
别名: Berberine HCl, Berberine Hydrochloride, Goldenseal extract, Oregon Grape extract
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About
小檗碱是一种异喹啉生物碱，存在于黄连、俄勒冈葡萄和小檗等多种植物中。它激活小肠上皮细胞中的AMPK通路，并对各种肠道病原体展现直接的抗菌活性。研究表明小檗碱可能有助于调节肠道微生物组组成，包括支持粘膜乳杆菌的生长。它越来越多地被研究作为小肠细菌过度生长草本抗菌方案的一部分。
How It Works
Activates AMPK pathway in enterocytes modulating cellular energy metabolism; directly antimicrobial against enteric pathogens (E. coli, Staphylococcus, Candida); modulates gut microbiome composition increasing Akkermansia muciniphila; enhances intestinal barrier via tight junction protein upregulation.
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| Acute Diarrhea | C | 4 | 400 | 查看 → |
| Small Intestinal Bacterial Overgrowth (SIBO) | C | 2 | 180 | 查看 → |
| Gut Dysbiosis | D | 2 | 100 | 查看 → |
Side Effects
- GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- May cause uterine contractions (contraindicated in pregnancy)
- Headache
- Skin rash (rare)
Drug & Supplement Interactions
- Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- Anticoagulants (may have additive blood-thinning effects)
- Metformin (additive glucose-lowering effect; monitor closely)
- Macrolide antibiotics (berberine inhibits CYP3A4)
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Related Ingredients
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