Berberine ： Gut Dysbiosis

Q: Does Berberine help with Gut Dysbiosis?

Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).

Q: How much Berberine should I take for Gut Dysbiosis?

Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Berberine?

Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Berberine and Gut Dysbiosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.

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結論

Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.

Key Study Findings

In Vitro

Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal …

Dose: None vs: Sulfasalazine; DSS-induced UC mice Outcome: UC treatment efficacy 効果: Colon length 1.2x longer than sulfasalazine None

対象集団: DSS-induced UC murine model

Review

Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Review

Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Review

Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver …

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Other

Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles.

Dose: None vs: Free berberine; DSS-induced UC model vs normal mice Outcome: DAI scores, inflammatory cytokines, gut microbiota 効果: None <0.01 (DAI); <0.05 (cytokines)

対象集団: DSS-induced UC mouse model (male KM mice)

Other

Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.

Dose: None vs: DSS-induced colitis + periodontitis mouse models Outcome: Periodontal destruction and myeloid cell generation 効果: None None

対象集団: DSS-induced colitis with periodontitis mouse model

Key Statistics

研究数

100

参加者数

↑

Positive

グレード

Referenced Papers

Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives. Review

International journal of … 2025 15 件の引用

Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal barrier and gut microbiota. Other

Colloids and surfaces. … 2025 11 件の引用

Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver Disease. Review

Pharmaceuticals (Basel, Switzerland) 2025 8 件の引用

Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent. Review

Pharmaceuticals (Basel, Switzerland) 2025 8 件の引用

Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis. Other

Inflammatory bowel diseases 2025 2 件の引用

Design and Activity Evaluation of Berberine-Loaded Dual pH and Enzyme-Sensitive Colon-Targeting Microparticles. Other

Pharmaceutics 2025 2 件の引用

Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment. Other

Phytomedicine : international … 2025 2 件の引用

Berberine alleviates metabolic dysfunction-associated steatohepatitis by enhancing the abundance of Akkermansia muciniphila. Other

The Journal of … 2025 1 件の引用

Oxyberberine alleviates fructose-induced hyperuricemia by modulating purine metabolism and gut microbiota. Other

European journal of … 2025

Phellodendron bark extract and berberine chloride suppress microbiome dysbiosis in a saliva-derived in vitro microcosm biofilm model. Other

Archives of oral … 2025

The role of traditional Chinese medicine in modulating gut microbiota to alleviating insulin resistance in polycystic ovary syndrome. Review

Frontiers in nutrition 2025

Integration of microbiome, metabolomics and transcriptome for in-depth understanding of berberine attenuates AOM/DSS-induced colitis-associated colorectal cancer. Other

Biomedicine & pharmacotherapy … 2024 17 件の引用

Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature. Systematic Review

International journal of … 2024 14 件の引用

Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on … Other

Frontiers in pharmacology 2024 9 件の引用

Berberine alleviates concanavalin A-induced autoimmune hepatitis in mice by modulating the gut microbiota. Other

Hepatology communications 2024 9 件の引用

Total Alkaloids of Rhizoma Corydalis regulates gut microbiota and restores gut immune barrier to ameliorate cognitive dysfunction in diabetic rats. Other

Frontiers in microbiology 2024 6 件の引用

Intestinal and hepatic benefits of BBR-EVO on DSS-induced experimental colitis in mice. Other

Frontiers in microbiology 2024 5 件の引用

Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance. Review

Indian journal of … 2024 2 件の引用

Colorectal cancer and gut microbiota studies in China. Review

Gut microbes 2023 108 件の引用

Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism. Other

Biomedicine & pharmacotherapy … 2023 61 件の引用

Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine. Other

International journal of … 2023 48 件の引用

Role of herbal medicine and gut microbiota in the prevention and treatment of obesity. Review

Journal of ethnopharmacology 2023 29 件の引用

Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. Other

Frontiers in pharmacology 2023 20 件の引用

Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies. Meta-Analysis

International journal of … 2023 18 件の引用

Alkaloids as Promising Agents for the Management of Insulin Resistance: A Review. Review

Current pharmaceutical design 2023 10 件の引用

An in vitro study of the effects of Phellodendron bark extract and berberine chloride on periodontal pathogenic bacteria in the … Other

Journal of oral … 2023 10 件の引用

Distinct Effects of Non-absorbed Agents Rifaximin and Berberine on the Microbiota-Gut-Brain Axis in Dysbiosis-induced Visceral Hypersensitivity in Rats. Other

Journal of neurogastroenterology … 2023 4 件の引用

Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome. Review

Clinical and experimental … 2023 2 件の引用

Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry. Review

Microorganisms 2022 212 件の引用

Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. Other

Food & function 2022 83 件の引用

Berberine suppresses colorectal cancer by regulation of Hedgehog signaling pathway activity and gut microbiota. Other

Phytomedicine : international … 2022 67 件の引用

An oral pH-activated "nano-bomb" carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative … Other

Biomaterials science 2022 34 件の引用

Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota. Other

Microbiology spectrum 2022 25 件の引用

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in … Other

Brazilian journal of … 2022 12 件の引用

Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent … Other

Pharmacological research 2021 186 件の引用

Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Other

Pharmacological research 2021 147 件の引用

Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation. Other

Acta pharmacologica Sinica 2021 63 件の引用

Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. Other

Frontiers in pharmacology 2021 42 件の引用

The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves' Disease Patients Through Regulating the Intestinal Microbiome. Other

Frontiers in immunology 2021 22 件の引用

Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease. Other

Comprehensive Physiology 2021 21 件の引用

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. Review

International journal of … 2021 20 件の引用

Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases. Review

Pharmacological research 2020 65 件の引用

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Systematic Review

Journal of integrative … 2020 33 件の引用

Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions. Review

Pharmacological research 2019 166 件の引用

Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids. Other

American journal of … 2019 117 件の引用

Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Other

Biomedicine & pharmacotherapy … 2019 72 件の引用

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice. Other

Scientific reports 2019 51 件の引用

Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. Review

Pharmacological research 2019 31 件の引用

Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis. Other

Science China. Life … 2018 17 件の引用

Nutritional Management of Metabolic Endotoxemia: A Clinical Review. Review

Alternative therapies in … 2017 9 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 500-1,500 mg/day in divided doses
siboprotocol:: 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
giantimicrobial:: 500 mg twice daily

上限量： Generally well-tolerated up to 1,500 mg/day in divided doses

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	6 weeks	Positive	--

推奨摂取タイミング： With meals; divide doses throughout the day (do not take full daily dose at once)

Safety & Side Effects

報告されている副作用

⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
⚠ May cause uterine contractions (contraindicated in pregnancy)
⚠ Headache
⚠ Skin rash (rare)

既知の相互作用

● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
● Anticoagulants (may have additive blood-thinning effects)
● Metformin (additive glucose-lowering effect; monitor closely)
● Macrolide antibiotics (berberine inhibits CYP3A4)

耐容上限摂取量： Generally well-tolerated up to 1,500 mg/day in divided doses

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Berberine help with Gut Dysbiosis?

Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Berberine may support Gut Dysbiosis management. Our evidence grade is D (Very Early Research).

How much Berberine should I take for Gut Dysbiosis?

Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Berberine?

Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Berberine and Gut Dysbiosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Gut Dysbiosis

Inulin D Medium-Chain Triglycerides (MCT Oil) D

Berberine 他の症状・状態について

Acute Diarrhea C Small Intestinal Bacterial Overgrowth (SIBO) C

総合評価

Preclinical evidence that berberine modulates microbiome composition. Limited human microbiome data.

Evidence Strength30%

Low confidence

研究の内訳

RCT (0)Meta (1)Other (1)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Gut Dysbiosis

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。