Berberine 用于 急性腹泻
C 证据 来自小型研究的证据有限，但存在一些积极信号。传统用于治疗细菌性腹泻，得到部分临床数据支持。对大肠杆菌、志贺菌和弧菌具有抗菌活性。
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C
结论
传统用于治疗细菌性腹泻，得到部分临床数据支持。对大肠杆菌、志贺菌和弧菌具有抗菌活性。
Key Study Findings
Other
Intestinal and hepatic benefits of BBR-EVO on DSS-induced experimental colitis in mice.
Dose: None
vs: None
Outcome: Colitis severity
效果: None
None
研究人群: Mouse model
Review
Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and …
Dose: Various phytochemicals
vs: None
Outcome: NF-kB regulation in IBD
效果: None
None
研究人群: In vitro and in vivo IBD models
Other
Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating …
Dose: None
vs: None
Outcome: Colitis, inflammation, gut microbiota, smooth muscle
效果: None
None
研究人群: DSS-induced UC cat model
Controlled Clinical Trial
Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary …
Dose: None
vs: DSS-colitis control
Outcome: Ulcerative colitis symptoms and markers
效果: None
None
研究人群: Mice with DSS-induced UC
In Vitro
Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis.
Dose: 200 mg/kg
vs: Control
Outcome: Diarrhea outcomes
效果: None
None
研究人群: None
Key Statistics
4
研究数量
400
受试者
↑
Positive
C
等级
Referenced Papers
Frontiers in microbiology
2024
5 次引用
Metabolites
2023
134 次引用
Microbiology spectrum
2022
25 次引用
Pharmacological research
2021
186 次引用
Biomedicine & pharmacotherapy …
2019
72 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 500-1,500 mg/day in divided doses
- siboprotocol:
- 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)
- giantimicrobial:
- 500 mg twice daily
上限： Generally well-tolerated up to 1,500 mg/day in divided doses
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 200 mg/kg | -- | Neutral | -- |
最佳服用时间： With meals; divide doses throughout the day (do not take full daily dose at once)
Safety & Side Effects
已报告的副作用
- ⚠ GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
- ⚠ May cause uterine contractions (contraindicated in pregnancy)
- ⚠ Headache
- ⚠ Skin rash (rare)
已知相互作用
- ● Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
- ● Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
- ● Anticoagulants (may have additive blood-thinning effects)
- ● Metformin (additive glucose-lowering effect; monitor closely)
- ● Macrolide antibiotics (berberine inhibits CYP3A4)
可耐受最高摄入量： Generally well-tolerated up to 1,500 mg/day in divided doses
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Berberine help with 急性腹泻?
Based on 4 studies with 400 participants, there is limited but promising evidence that Berberine may support 急性腹泻 management. Our evidence grade is C (Some Evidence).
How much Berberine should I take for 急性腹泻?
Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Berberine?
Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Berberine and 急性腹泻?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 急性腹泻
Berberine 用于其他健康状况
References
- [1] Wenjia Wang et al.. Front Microbiol. 2024. Intestinal and hepatic benefits of BBR-EVO on DSS-induced experimental colitis in mice. doi:10.3389/fmicb.2024.1428327 PubMed
- [2] Lucas Fornari Laurindo et al.. Metabolites. 2023. Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects. doi:10.3390/metabo13010096 PubMed
- [3] Xueying Li et al.. Microbiol Spectr. 2022. Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota. doi:10.1128/spectrum.03207-22 PubMed
- [4] Qinmei Li et al.. Pharmacol Res. 2021. Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent … doi:10.1016/j.phrs.2021.105694 PubMed
- [5] Shi-Jun Yue et al.. Biomed Pharmacother. 2019. Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. doi:10.1016/j.biopha.2019.109002 PubMed
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