Vitamin D cho Irritable Bowel Syndrome (IBS)

Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.

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Kết luận

Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.

Key Study Findings

Review

Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …

Dose: None so với: None Outcome: IBS symptom improvement with vitamin D supplementation Hiệu quả: None None

Đối tượng nghiên cứu: individuals with irritable bowel syndrome

Systematic Review

Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …

Dose: None so với: Various Outcome: IBS symptom improvement Hiệu quả: Probiotics abdominal pain RR 4.04 (2.36-6.92) None

Đối tượng nghiên cứu: Adult IBS patients

Meta-Analysis Double-blind

The effects of vitamin D intake and status on symptom severity and quality-of-life in adults …

Dose: 3,000 IU daily to 50,000 IU bi-weekly so với: Placebo Outcome: IBS symptom severity and quality of life Hiệu quả: MD 20.33 ng/mL [12.91, 27.74] for 25(OH)D; QoL 3.1 None

Đối tượng nghiên cứu: Adults with IBS and deficient/insufficient vitamin D

Review

Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review.

Dose: None so với: None Outcome: Risk of developing Parkinson's disease Hiệu quả: None None

Đối tượng nghiên cứu: General population (narrative review of PD risk factors)

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None so với: None Outcome: Micronutrient deficiency management in pediatric IBD Hiệu quả: None None

Đối tượng nghiên cứu: Children with inflammatory bowel disease (review)

Review

Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.

Dose: None so với: None Outcome: IBS symptom relief and pathophysiology modulation Hiệu quả: None None

Đối tượng nghiên cứu: Patients with irritable bowel syndrome (review)

Key Statistics

Nghiên cứu

400

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future Research Opportunities. Other

Gastroenterology nursing : … None 4 trích dẫn

Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical … Systematic Review

Nutrition reviews 2025 10 trích dẫn

Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results … RCT

Nutrients 2025 7 trích dẫn

Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review. Review

Arquivos de neuro-psiquiatria 2025 6 trích dẫn

The effects of vitamin D intake and status on symptom severity and quality-of-life in adults with irritable bowel syndrome (IBS): … Meta-Analysis

Critical reviews in … 2025 6 trích dẫn

Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology. Review

Nutrients 2025 4 trích dẫn

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 trích dẫn

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. Review

Current nutrition reports 2025 3 trích dẫn

Impact of vitamin D supplementation on symptom severity and quality of life in patients with irritable bowel syndrome: A meta-analysis. Meta-Analysis

Advances in clinical … 2025 2 trích dẫn

Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach. Review

Nutrients 2025 1 trích dẫn

Vitamin D Deficiency and Supplementation in Irritable Bowel Syndrome: Retrospective Evaluation of Subtype and Sex-Based Differences. Other

Medicina (Kaunas, Lithuania) 2025

Intake of fiber and micronutrients in patients with IBS. Other

Scandinavian journal of … 2025

Intestinal Barrier Impairment, Preservation, and Repair: An Update. Review

Nutrients 2024 47 trích dẫn

Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal … Review

Nutrients 2024 27 trích dẫn

Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. Other

Poultry science 2024 9 trích dẫn

Overweight and vitamin D deficiency are common in patients with irritable bowel syndrome - a cross-sectional study. Other

BMC gastroenterology 2024 8 trích dẫn

Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. Review

Nutrients 2024 5 trích dẫn

Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome. Other

Nutrients 2024 4 trích dẫn

Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Other

Minerva gastroenterology 2024 4 trích dẫn

Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome. Review

Nutrients 2023 32 trích dẫn

The interaction between obesity and visceral hypersensitivity. Review

Journal of gastroenterology … 2023 16 trích dẫn

Vitamin D may alleviate irritable bowel syndrome by modulating serotonin synthesis: a hypothesis based on recent literature. Review

Frontiers in physiology 2023 13 trích dẫn

Role of in vitamin D in irritable bowel syndrome. Review

World journal of … 2023 9 trích dẫn

Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis. Other

Heliyon 2023 7 trích dẫn

The preventive role of vitamin D in the prevention and management of Fibromyalgia syndrome. Review

Nutrition and health 2023 4 trích dẫn

Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea … Other

Neurogastroenterology and motility 2023 4 trích dẫn

Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and … Systematic Review

Biological research for … 2023 3 trích dẫn

Irritable bowel syndrome and endometriosis: diagnosis, similarities, and nutritional management. Other

British journal of … 2023 2 trích dẫn

The efficacy of vitamin D supplementation for irritable bowel syndrome: narrow scope and GRADE miss-interpretation. Review

Nutrition journal 2023

Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis. Meta-Analysis

Journal of gastroenterology … 2022 30 trích dẫn

Association between irritable bowel syndrome and micronutrients: A systematic review. Systematic Review

Journal of gastroenterology … 2022 29 trích dẫn

The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Meta-Analysis

Nutrition journal 2022 28 trích dẫn

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome … Meta-Analysis

Nutrients 2022 24 trích dẫn

Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by … Other

PloS one 2022 10 trích dẫn

Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: a systematic review and meta-analysis. Meta-Analysis

Nutricion hospitalaria 2022 9 trích dẫn

Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults. Other

Nutrients 2022 7 trích dẫn

Vitamin D supplementation for irritable bowel syndrome: Concerns about the meta-analysis. Other

Journal of gastroenterology … 2022 4 trích dẫn

Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review. Systematic Review

Nutrients 2021 16 trích dẫn

Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome. Other

Journal of gastroenterology … 2021 10 trích dẫn

[Role of vitamin D in pediatric irritable bowel syndrome]. Review

Zhongguo dang dai … 2021

Gut-brain Axis and migraine headache: a comprehensive review. Review

The journal of … 2020 294 trích dẫn

The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis. Meta-Analysis

Osteoporosis international : … 2020 14 trích dẫn

Pharmacological and Non-pharmacological Treatments of Irritable Bowel Syndrome and Their Impact on the Quality of Life: A Literature Review. Review

Cureus 2020 10 trích dẫn

Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D. Review

Expert review of … 2019 33 trích dẫn

Effectiveness of vitamin D for irritable bowel syndrome: A protocol for a systematic review of randomized controlled trial. Other

Medicine 2019 4 trích dẫn

Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what … Systematic Review

European journal of … 2018 39 trích dẫn

Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial. RCT

Saudi journal of … 2018 38 trích dẫn

A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression. RCT

The Australian and … 2017 280 trích dẫn

Lactase Non-persistence and Lactose Intolerance. Review

Current gastroenterology reports 2017 157 trích dẫn

Vitamin D status in pediatric irritable bowel syndrome. Other

PloS one 2017 38 trích dẫn

Correction: Vitamin D status in pediatric irritable bowel syndrome. Other

PloS one 2017 5 trích dẫn

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 trích dẫn

Dietary Intakes and Supplement Use in Pre-Adolescent and Adolescent Canadian Athletes. Other

Nutrients 2016 55 trích dẫn

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 trích dẫn

Nutrition and skin: Kids are not just little people. Review

Clinics in dermatology 2016 19 trích dẫn

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 trích dẫn

Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist? Other

Oman medical journal 2015 56 trích dẫn

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 trích dẫn

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 trích dẫn

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 trích dẫn

Dietary supplements for established atopic eczema. Meta-Analysis

The Cochrane database … 2012 130 trích dẫn

Nutrition and inflammatory bowel disease: primary or adjuvant therapy. Review

Current opinion in … 2011 23 trích dẫn

Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. Other

Acta psychiatrica Scandinavica 1979 22 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 600-800 IU/day (RDA)
ibdsupport:: 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
deficiencycorrection:: 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance

Giới hạn trên: 4,000 IU/day (100 mcg); higher doses under medical supervision only

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	--
None	--	Positive	--
3,000 IU daily to 50,000 IU bi-weekly	--	Positive	--
None	--	Mixed	--
None	--	Neutral	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	240

Thời điểm dùng tốt nhất: With a meal containing fat for better absorption

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
⚠ Kidney stones with excessive long-term supplementation
⚠ Constipation
⚠ Metallic taste

Tương tác đã biết

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

Mức hấp thụ tối đa cho phép: 4,000 IU/day (100 mcg); higher doses under medical supervision only

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Vitamin D help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 400 participants, there is limited but promising evidence that Vitamin D may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).

How much Vitamin D should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

Vitamin D cho các tình trạng khác

Inflammatory Bowel Disease (IBD) — General B

Đánh giá nhanh

Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.

Evidence Strength52%

Moderate confidence

Phân tích nghiên cứu

RCT (3)Meta (8)Other (0)

So sánh lựa chọn thay thế

Xem các thành phần khác so sánh như thế nào cho tình trạng này.

Xem tất cả thành phần cho Irritable Bowel Syndrome (IBS)

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