Partially Hydrolyzed Guar Gum (PHGG) cho Irritable Bowel Syndrome (IBS)
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.Reduces both IBS-C and IBS-D symptoms. Well-tolerated prebiotic that does not cause excess gas. Also shows promise for SIBO-associated symptoms.
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B
Kết luận
Reduces both IBS-C and IBS-D symptoms. Well-tolerated prebiotic that does not cause excess gas. Also shows promise for SIBO-associated symptoms.
Key Study Findings
Randomized Controlled Trial
n=47
8 weeks
Double-blind
Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and …
Dose: None
so với: Placebo (Group I) and partial formulation (Group II)
Outcome: IBS quality of life (QoL questionnaire)
Hiệu quả: Dysphoria: median diff -5 (Group III) vs -1 (contr
0.0021 (dysphoria Group III)
Đối tượng nghiên cứu: Patients with IBS
Controlled Clinical Trial
Changes in intestinal microbiota and biochemical parameters in patients with inflammatory bowel disease and irritable …
Dose: Partially hydrolyzed guar gum (PHGG)
so với: Drug therapy alone
Outcome: Gut bacteria ratios and inflammatory markers
Hiệu quả: None
None
Đối tượng nghiên cứu: Patients with IBD or IBS on drug therapy
Controlled Clinical Trial
12.9 weeks
Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel …
Dose: None
so với: baseline
Outcome: IBS symptom improvement
Hiệu quả: None
None
Đối tượng nghiên cứu: Ibs undertook a 90-day intervention and follow-up
Case Reports
Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Randomized Controlled Trial
13.0 weeks
Double-blind
Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: …
Dose: None
so với: Placebo
Outcome: Bowel function
Hiệu quả: None
p=0.05
Đối tượng nghiên cứu: healthy volunteers
Randomized Controlled Trial
12 weeks
Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients …
Dose: partially hydrolyzed guar gum (PHGG) 5g/day
so với: placebo
Outcome: IBS-SSS and bloating severity
Hiệu quả: significant improvement in overall IBS-SSS
<0.05
Đối tượng nghiên cứu: Adults with IBS
Key Statistics
5
Nghiên cứu
350
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
Frontiers in nutrition
2025
3 trích dẫn
The journal of …
2024
2 trích dẫn
Nutrients
2023
3 trích dẫn
Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases.
Case Report
Expert review of …
2021
7 trích dẫn
Nutrients
2019
68 trích dẫn
Nutrition & metabolism
2016
61 trích dẫn
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Systematic Review
Journal of pediatric …
2016
19 trích dẫn
Saudi journal of …
2015
32 trích dẫn
World journal of …
2013
69 trích dẫn
Minerva gastroenterologica e …
2013
Nutrition (Burbank, Los …
2006
119 trích dẫn
Digestive diseases and …
2005
55 trích dẫn
Nutrition (Burbank, Los …
2003
143 trích dẫn
Digestive diseases and …
2002
117 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 5-7 g/day
- ibssupport:
- 5 g/day for 4-12 weeks
- siboadjunct:
- 5 g/day alongside antimicrobial therapy
Giới hạn trên: Well-tolerated up to 36 g/day in clinical trials
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | 8 weeks | Positive | 47 |
| Partially hydrolyzed guar gum (PHGG) | -- | Positive | -- |
| None | 12.9 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | 13.0 weeks | Mixed | -- |
| partially hydrolyzed guar gum (PHGG) 5g/day | 12 weeks | Positive | -- |
| various probiotic strains | -- | Mixed | -- |
| None | 4.0 weeks | Positive | -- |
Thời điểm dùng tốt nhất: Mixed into food or beverages; dissolves completely without altering texture
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Minimal gas and bloating (significantly less than other fibers)
- ⚠ Mild abdominal discomfort in rare cases
- ⚠ Loose stools at very high doses
Tương tác đã biết
- ● May slow absorption of some medications (space 1-2 hours)
- ● Diabetes medications (may modestly affect blood glucose)
Mức hấp thụ tối đa cho phép: Well-tolerated up to 36 g/day in clinical trials
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Partially Hydrolyzed Guar Gum (PHGG) help with Irritable Bowel Syndrome (IBS)?
Based on 5 studies with 350 participants, there is moderate evidence from clinical studies that Partially Hydrolyzed Guar Gum (PHGG) may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Partially Hydrolyzed Guar Gum (PHGG) should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 5-7 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Partially Hydrolyzed Guar Gum (PHGG)?
Reported side effects may include Minimal gas and bloating (significantly less than other fibers), Mild abdominal discomfort in rare cases, Loose stools at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Partially Hydrolyzed Guar Gum (PHGG) and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Irritable Bowel Syndrome (IBS)
Partially Hydrolyzed Guar Gum (PHGG) cho các tình trạng khác
References
- [1] Adrianna Wierzbicka et al.. Front Nutr. 2025. Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients … doi:10.3389/fnut.2025.1603011 PubMed
- [2] Hideo Watanabe et al.. J Med Invest. 2024. Changes in intestinal microbiota and biochemical parameters in patients with inflammatory bowel disease and irritable bowel syndrome induced by the … doi:10.2152/jmi.71.121 PubMed
- [3] Jerry Zhou et al.. Nutrients. 2023. Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome. doi:10.3390/nu15224786 PubMed
- [4] Claudio Romano et al.. Expert Rev Gastroenterol Hepatol. 2021. Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases. doi:10.1080/17474124.2021.1884543 PubMed
- [5] Zenta Yasukawa et al.. Nutrients. 2019. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and … doi:10.3390/nu11092170 PubMed
- [6] E Niv et al.. Nutr Metab (Lond). 2016. Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome. doi:10.1186/s12986-016-0070-5 PubMed
- [7] Eleonora Giannetti et al.. J Pediatr Gastroenterol Nutr. 2016. Probiotics for Irritable Bowel Syndrome: Clinical Data in Children. doi:10.1097/MPG.0000000000001220 PubMed
- [8] Luigi Russo et al.. Saudi J Gastroenterol. 2015. Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: effects of gender, age, and body mass … doi:10.4103/1319-3767.153835 PubMed
- [9] Claudio Romano et al.. World J Gastroenterol. 2013. Partially hydrolyzed guar gum in pediatric functional abdominal pain. doi:10.3748/wjg.v19.i2.235 PubMed
- [10] G Quartarone. Minerva Gastroenterol Dietol. 2013. Role of PHGG as a dietary fiber: a review article. PubMed
- [11] Edoardo G Giannini et al.. Nutrition. 2006. Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. doi:10.1016/j.nut.2005.10.003 PubMed
- [12] Giancarlo Parisi et al.. Dig Dis Sci. 2005. Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A … doi:10.1007/s10620-005-2713-7 PubMed
- [13] Joanne L Slavin et al.. Nutrition. 2003. Partially hydrolyzed guar gum: clinical nutrition uses. doi:10.1016/s0899-9007(02)01032-8 PubMed
- [14] G C Parisi et al.. Dig Dis Sci. 2002. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet … doi:10.1023/a:1016419906546 PubMed
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