L-Glutamine ： Increased Intestinal Permeability (Leaky Gut)
DSmall studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.
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D
結論
Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.
Key Study Findings
Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None
vs: None
Outcome: Intestinal barrier preservation and repair
効果: None
None
対象集団: IBD and IBS patients (review)
Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None
vs: None
Outcome: Cholesterol levels
効果: None
None
対象集団: Mouse model
In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None
vs: None
Outcome: inflammation markers
効果: None
None
対象集団: Mice
Other
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Systematic Review
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Dose: None
vs: Placebo or standard care
Outcome: IBD symptom improvement
効果: None
None
対象集団: IBD patients
Controlled Clinical Trial
n=43
4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d
vs: None
Outcome: None
効果: None
None
対象集団: IBS patients
Key Statistics
2
研究数
80
参加者数
↑
Positive
D
グレード
Referenced Papers
Nutrients
2024
47 件の引用
Cannabis and cannabinoid …
2024
10 件の引用
International journal of …
2023
9 件の引用
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Systematic Review
Clinical nutrition ESPEN
2021
39 件の引用
Advances in nutrition …
2021
34 件の引用
Nutrition research (New …
2020
42 件の引用
Gut
2019
148 件の引用
Current opinion in …
2017
71 件の引用
JPEN. Journal of …
2016
44 件の引用
Glutamine for induction of remission in Crohn's disease.
Systematic Review
The Cochrane database …
2016
37 件の引用
Gastroenterology
2015
17 件の引用
Scandinavian journal of …
2014
56 件の引用
Digestive diseases and …
2012
81 件の引用
Clinical nutrition (Edinburgh, …
2011
12 件の引用
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome.
Other
Gut
2010
263 件の引用
Clinics (Sao Paulo, …
2010
47 件の引用
Nutrition in clinical …
2008
42 件の引用
Clinical nutrition (Edinburgh, …
2005
43 件の引用
JPEN. Journal of …
2000
18 件の引用
JPEN. Journal of …
1999
129 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
上限量： Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 5 g/d | 4 weeks | Positive | 43 |
| 5 g | 8.0 weeks | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
報告されている副作用
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
既知の相互作用
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
耐容上限摂取量： Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?
Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).
How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Increased Intestinal Permeability (Leaky Gut)
L-Glutamine 他の症状・状態について
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