Inulin : Gut Dysbiosis
D 研究 予備的な研究(実験室研究、症例報告)のみが存在します。Increases Bifidobacterium counts (1-2 log). Whether this diversity improvement translates to clinical outcomes is unclear.
結論
Increases Bifidobacterium counts (1-2 log). Whether this diversity improvement translates to clinical outcomes is unclear.
Key Study Findings
対象集団: review of prebiotics, probiotics, synbiotics, postbiotics for gastrointestinal inflammation
対象集団: healthy individuals, children, elderly, and those with constipation, metabolic syndrome, or dysbiosis
対象集団: Women with PCOS and insulin resistance
対象集団: None
対象集団: UC murine model
対象集団: Chronic ketamine-exposed mice
Key Statistics
3
研究数
200
参加者数
Positive
グレード
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 5-10 g/day
- constipationsupport:
- 12 g/day for 4 weeks
- prebioticmaintenance:
- 5-8 g/day
上限量: Well-tolerated up to 20 g/day; start low and increase gradually
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | 2 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | 26 weeks | Mixed | 144 |
推奨摂取タイミング: With meals; divide doses throughout the day to minimize gas
Safety & Side Effects
報告されている副作用
- ⚠ Gas and bloating (common at higher doses; start with 3-5 g/day and titrate up)
- ⚠ Abdominal cramping
- ⚠ Flatulence
- ⚠ Loose stools at very high doses
既知の相互作用
- ● May enhance absorption of calcium and magnesium (beneficial interaction)
- ● Blood sugar-lowering medications (inulin may modestly reduce blood glucose)
- ● Other FODMAPs (cumulative fermentation may worsen symptoms in sensitive individuals)
耐容上限摂取量: Well-tolerated up to 20 g/day; start low and increase gradually
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Inulin help with Gut Dysbiosis?
How much Inulin should I take for Gut Dysbiosis?
Are there side effects of Inulin?
How strong is the evidence for Inulin and Gut Dysbiosis?
Related Evidence
に関する他の成分: Gut Dysbiosis
Inulin 他の症状・状態について
References
- [1] Cinara Regina A V Monteiro et al.. Nutrients. 2026. Prebiotics and Gut Health: Mechanisms, Clinical Evidence, and Future Directions. doi:10.3390/nu18030372 PubMed
- [2] Radhika Baheti et al.. Food Res Int. 2026. Interplay of probiotics, prebiotics, synbiotics and postbiotics: a review of their therapeutic potential for gastrointestinal inflammation. doi:10.1016/j.foodres.2026.118598 PubMed
- [3] Samuel Bogdan Todor et al.. Children (Basel). 2025. Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review. doi:10.3390/children12020166 PubMed
- [4] Kun Zhang et al.. ACS Nano. 2025. Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel. doi:10.1021/acsnano.5c08982 PubMed
- [5] Zhilong Xu et al.. Int J Biol Macromol. 2025. Inulin alleviates chronic ketamine-induced impairments in memory and prepulse inhibition by regulating the gut microbiota, inflammation, and kynurenine pathway. doi:10.1016/j.ijbiomac.2025.139503 PubMed
- [6] Maria Abou Diwan et al.. Environ Pollut. 2025. Effects of Chlorpyrifos on gut dysbiosis and barriers integrity in women with a focus on pregnancy and prebiotic intervention: Insights … doi:10.1016/j.envpol.2024.125533 PubMed
- [7] Sunhee Jung et al.. Nat Metab. 2025. Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis. doi:10.1038/s42255-025-01356-0 PubMed
- [8] Jiahan Wang et al.. Free Radic Biol Med. 2025. Indole lactic acid derived from Akkermansia muciniphila activates the aryl hydrocarbon receptor to inhibit ferroptosis in ischemic stroke. doi:10.1016/j.freeradbiomed.2025.04.020 PubMed
- [9] Silong Wu et al.. Small. 2025. Comprehensive Management of Ulcerative Colitis and its Associated Intra-Extra Intestinal Complications with a Multifunctional Inulin Hydrogel Complex. doi:10.1002/smll.202500726 PubMed
- [10] Giorgia Sarti et al.. Front Pharmacol. 2025. Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice. doi:10.3389/fphar.2025.1596469 PubMed
- [11] Carol Huang et al.. BMJ Open. 2025. Prebiotic supplementation in patients with type 1 diabetes: study protocol for a randomised controlled trial in Canada. doi:10.1136/bmjopen-2025-102486 PubMed
- [12] Camille Amadieu et al.. Clin Nutr ESPEN. 2025. Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention. doi:10.1016/j.clnesp.2025.01.046 PubMed
- [13] Tushar Andriyas et al.. Sci Rep. 2025. Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity. doi:10.1038/s41598-025-21079-2 PubMed
- [14] Priya Makhijani et al.. Cell Rep. 2025. Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice. doi:10.1016/j.celrep.2025.116109 PubMed
- [15] Marie-Luise Puhlmann et al.. BMC Gastroenterol. 2025. Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of a randomized, double-blind, placebo-controlled study. doi:10.1186/s12876-025-04409-6 PubMed
- [16] Lin Yin et al.. Front Nutr. 2025. The role of traditional Chinese medicine in modulating gut microbiota to alleviating insulin resistance in polycystic ovary syndrome. doi:10.3389/fnut.2025.1700612 PubMed
- [17] Yaoyu Hu et al.. ACS Nano. 2025. Hydrogen Therapy and Lipopolysaccharide Trapping with MgB2@Inulin Gel for Reversing Colitis and Its Associated Psychiatric Complications via the Gut-Brain Axis. doi:10.1021/acsnano.5c03843 PubMed
- [18] Jia-Hao Li et al.. Brain Behav Immun. 2025. Gut microbiota mediates prenatal METH exposure-induced anxiety- and depression-like behaviors by modulating the Wnt signaling pathway. doi:10.1016/j.bbi.2025.106112 PubMed
- [19] Jia Yang et al.. Gastroenterology. 2024. High Soluble Fiber Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites in Mice. doi:10.1053/j.gastro.2023.10.012 PubMed
- [20] Xiangjing Cao et al.. Nat Commun. 2024. Ternary inulin hydrogel with long-term intestinal retention for simultaneously reversing IBD and its fibrotic complication. doi:10.1038/s41467-024-52722-7 PubMed
- [21] Chonnikant Visuthranukul et al.. Int J Obes (Lond). 2024. Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity. doi:10.1038/s41366-024-01590-8 PubMed
- [22] Achuthan Ambat et al.. Gut Microbes. 2024. Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing … doi:10.1080/19490976.2024.2382324 PubMed
- [23] Kai Han et al.. Nat Mater. 2024. Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy. doi:10.1038/s41563-024-01909-w PubMed
- [24] Kuan Li et al.. Phytomedicine. 2024. Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism. doi:10.1016/j.phymed.2024.156181 PubMed
- [25] Oana C Iatcu et al.. Nutrients. 2024. Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes. doi:10.3390/nu16203447 PubMed
- [26] Xin Li et al.. Gut Microbes. 2024. Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis. doi:10.1080/19490976.2024.2436949 PubMed
- [27] Miloš Mitrović et al.. Rom J Intern Med. 2024. The effects of synbiotics on the liver steatosis, inflammation, and gut microbiome of metabolic dysfunction-associated liver disease patients-randomized trial. doi:10.2478/rjim-2024-0004 PubMed
- [28] Amin Ariaee et al.. Foods. 2024. The Degree of Inulin Polymerization Is Important for Short-Term Amelioration of High-Fat Diet (HFD)-Induced Metabolic Dysfunction and Gut Microbiota Dysbiosis … doi:10.3390/foods13071039 PubMed
- [29] Chen Hou et al.. J Agric Food Chem. 2024. Pomegranate Juice Supplemented with Inulin Modulates Gut Microbiota and Promotes the Production of Microbiota-Associated Metabolites in Overweight/Obese Individuals: A Randomized, … doi:10.1021/acs.jafc.4c00849 PubMed
- [30] Nauryzbay Imanbayev et al.. Prz Gastroenterol. 2024. Colorectal cancer and microbiota: systematic review. doi:10.5114/pg.2024.136228 PubMed
- [31] Lucas de Freitas Pedrosa et al.. Nutrients. 2024. From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance. doi:10.3390/nu16244286 PubMed
- [32] Helene Israelson et al.. mBio. 2024. Diet composition drives tissue-specific intensity of murine enteric infections. doi:10.1128/mbio.02603-23 PubMed
- [33] Anastasios Mpountouridis et al.. Front Gastroenterol (Lausanne). 2024. Gut microbiome in non-alcoholic fatty liver disease. doi:10.3389/fgstr.2024.1534431 PubMed
- [34] Supriya Roy et al.. World J Gastroenterol. 2023. Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives. doi:10.3748/wjg.v29.i14.2078 PubMed
- [35] Claudia Di Rosa et al.. Nutrients. 2023. Constipation-Predominant Irritable Bowel Syndrome (IBS-C): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms. doi:10.3390/nu15071647 PubMed
- [36] Elnaz Vaghef-Mehrabani et al.. Br J Nutr. 2023. Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: … doi:10.1017/S000711452200232X PubMed
- [37] Dillon P Kiernan et al.. Animals (Basel). 2023. The Effect of Prebiotic Supplements on the Gastrointestinal Microbiota and Associated Health Parameters in Pigs. doi:10.3390/ani13193012 PubMed
- [38] Javier Moleón et al.. Gut Microbes. 2023. Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus … doi:10.1080/19490976.2023.2247053 PubMed
- [39] Alejandra Romo-Araiza et al.. Cell Transplant. 2023. Symbiotic Supplementation (E. faecium and Agave Inulin) Improves Spatial Memory and Increases Plasticity in the Hippocampus of Obese Rats: A … doi:10.1177/09636897231177357 PubMed
- [40] Ya-Hsuan Chang et al.. Sci Rep. 2023. Prebiotic inulin enhances gut microbial metabolism and anti-inflammation in apolipoprotein E4 mice with sex-specific implications. doi:10.1038/s41598-023-42381-x PubMed
- [41] Joanna Szala-Rycaj et al.. Nutrients. 2023. The Influence of Topinambur and Inulin Preventive Supplementation on Microbiota, Anxious Behavior, Cognitive Functions and Neurogenesis in Mice Exposed to … doi:10.3390/nu15092041 PubMed
- [42] Katarzyna Ferenc et al.. Nutrients. 2022. Components of the Fiber Diet in the Prevention and Treatment of IBD-An Update. doi:10.3390/nu15010162 PubMed
- [43] Lucille M Yanckello et al.. J Cell Immunol. 2022. Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase. doi:10.33696/immunology.4.132 PubMed
- [44] Lucille M Yanckello et al.. Front Microbiomes. 2022. Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice. doi:10.3389/frmbi.2022.986951 PubMed
- [45] Lijia Fan et al.. Transl Pediatr. 2021. Enteral feeding and the microbiome in critically ill children: a narrative review. doi:10.21037/tp-20-349 PubMed
- [46] Quentin Le Bastard et al.. Eur J Clin Microbiol Infect Dis. 2020. The effects of inulin on gut microbial composition: a systematic review of evidence from human studies. doi:10.1007/s10096-019-03721-w PubMed
- [47] Rafael Ballan et al.. Prog Mol Biol Transl Sci. 2020. Interactions of probiotics and prebiotics with the gut microbiota. doi:10.1016/bs.pmbts.2020.03.008 PubMed
- [48] Jessie B Hoffman et al.. Environ Pollut. 2020. Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice. doi:10.1016/j.envpol.2020.114183 PubMed
- [49] Jing Gao et al.. Curr Pharm Des. 2020. Impact of Prebiotics on Enteric Diseases and Oxidative Stress. doi:10.2174/1381612826666200211121916 PubMed
- [50] Jing Xue et al.. Endocr J. 2019. Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice. doi:10.1507/endocrj.EJ18-0567 PubMed
- [51] Timo A Thumann et al.. J Ethnopharmacol. 2019. The role of gut microbiota for the activity of medicinal plants traditionally used in the European Union for gastrointestinal disorders. doi:10.1016/j.jep.2019.112153 PubMed
- [52] Silvia Lai et al.. Nutrients. 2019. Effect of Low-Protein Diet and Inulin on Microbiota and Clinical Parameters in Patients with Chronic Kidney Disease. doi:10.3390/nu11123006 PubMed
- [53] Vishal Singh et al.. Cell. 2018. Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. doi:10.1016/j.cell.2018.09.004 PubMed
- [54] Xiulan Guo et al.. Front Microbiol. 2018. Rutin and Its Combination With Inulin Attenuate Gut Dysbiosis, the Inflammatory Status and Endoplasmic Reticulum Stress in Paneth Cells of … doi:10.3389/fmicb.2018.02651 PubMed
- [55] Ashwin N Ananthakrishnan et al.. Cell Host Microbe. 2017. Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases. doi:10.1016/j.chom.2017.04.010 PubMed
- [56] Wen-Bei Han et al.. Zhongguo Zhong Yao Za Zhi. 2017. [Pathomechanism and treatment of gut microbiota dysbiosis in chronic kidney disease and interventional effects of Chinese herbal medicine]. doi:10.19540/j.cnki.cjcmm.20170609.014 PubMed
- [57] Kenichiro Takahashi et al.. Digestion. 2016. Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. doi:10.1159/000441768 PubMed
- [58] F Di Bartolomeo et al.. Phytother Res. 2013. Prebiotics to fight diseases: reality or fiction? doi:10.1002/ptr.4901 PubMed
FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。