Vitamin A के लिए Increased Intestinal Permeability (Leaky Gut)
CRetinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
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C
निष्कर्ष
Retinoic acid signaling maintains epithelial integrity and IgA production. Supplementation benefits seen primarily in deficient populations.
Key Study Findings
Observational Study
n=54
Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in …
Dose: None
बनाम: None
Outcome: Intestinal permeability (lactulose:mannitol ratio)
प्रभाव: AOR 0.15 (CI 0.05-0.42) for retinol
<0.001
जनसंख्या: Community-dwelling elderly individuals
Other
12 weeks
Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.
Dose: None
बनाम: HFD control mice
Outcome: NAFLD biomarkers and gut microbiota composition
प्रभाव: None
None
जनसंख्या: HFD-induced NAFLD mouse model
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
बनाम: None
Outcome: Athletic performance and nutritional optimization
प्रभाव: None
None
जनसंख्या: Vegan athletes (narrative review)
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
बनाम: None
Outcome: DALYs and mortality rates of congenital birth defects
प्रभाव: DALYs decreased 59.77%, deaths decreased 63.81%
None
जनसंख्या: G20 countries population, 1990-2021
Other
12 weeks
Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and …
Dose: None
बनाम: None
Outcome: Cognitive function
प्रभाव: None
None
जनसंख्या: Mouse model (APP/PS1)
In Vitro
Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.
Dose: None
बनाम: None
Outcome: oxidative stress markers
प्रभाव: None
p < 0.05
जनसंख्या: Chickens
Key Statistics
3
अध्ययन
250
प्रतिभागी
↑
Positive
C
ग्रेड
Referenced Papers
BMC pregnancy and …
2025
6 उद्धरण
Current nutrition reports
2025
3 उद्धरण
NPJ science of …
2025
2 उद्धरण
Scientific reports
2025
Frontiers in nutrition
2024
12 उद्धरण
Journal of animal …
2023
11 उद्धरण
Food science & …
2023
2 उद्धरण
International journal of …
2022
60 उद्धरण
Journal of Nippon …
2021
26 उद्धरण
Frontiers in immunology
2021
8 उद्धरण
Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A …
Systematic Review
Psychiatry research
2020
60 उद्धरण
Journal of diabetes …
2020
11 उद्धरण
Blood
2017
49 उद्धरण
ACS chemical neuroscience
2017
20 उद्धरण
World journal of …
2016
238 उद्धरण
Clinics in dermatology
2016
19 उद्धरण
The Journal of …
2015
31 उद्धरण
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 उद्धरण
Nutrition and cancer
2014
5 उद्धरण
Blood
2013
54 उद्धरण
European journal of …
2012
225 उद्धरण
Journal of burn …
2012
16 उद्धरण
Medical oncology (Northwood, …
2010
12 उद्धरण
Scandinavian journal of …
2010
6 उद्धरण
Journal of nutritional …
2010
2 उद्धरण
European journal of …
2009
24 उद्धरण
Veterinary parasitology
2008
80 उद्धरण
Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Other
American journal of …
2008
25 उद्धरण
European journal of …
2005
2 उद्धरण
Journal of health, …
2003
The British journal …
2002
358 उद्धरण
Rossiiskii fiziologicheskii zhurnal …
2002
Journal of pediatric …
2001
56 उद्धरण
Journal of acquired …
2001
15 उद्धरण
The Pediatric infectious …
2000
14 उद्धरण
Life sciences
1998
35 उद्धरण
Biulleten' eksperimental'noi biologii …
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 700-900 mcg RAE/day (RDA for adults)
- gutbarriersupport:
- 900 mcg RAE/day from mixed sources
- deficiencycorrection:
- 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)
अधिकतम सीमा: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Negative | 54 |
| None | 12 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 12 weeks | Negative | -- |
| None | -- | Positive | -- |
| None | 11 weeks | Positive | -- |
| 10 mg/kg | -- | Negative | -- |
सेवन का सर्वोत्तम समय: With meals containing fat for better absorption
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
- ⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
- ⚠ Nausea, headache, and dizziness
- ⚠ Bone density reduction with long-term excess
ज्ञात अंतःक्रियाएँ
- ● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk of vitamin A)
- ● Tetracycline antibiotics (increased risk of intracranial pressure)
सहनीय अधिकतम सेवन: 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Vitamin A help with Increased Intestinal Permeability (Leaky Gut)?
Based on 3 studies with 250 participants, there is limited but promising evidence that Vitamin A may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is C (Some Evidence).
How much Vitamin A should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Increased Intestinal Permeability (Leaky Gut)
Vitamin A अन्य स्वास्थ्य स्थितियों के लिए
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।