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Deglycyrrhizinated Licorice (DGL) के लिए Peptic Ulcer Disease

C

Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

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निष्कर्ष

            
            
Older clinical studies showed DGL comparable to cimetidine for ulcer healing. Modern evidence is limited.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
            
            

                
                Dose: None
                
                
                बनाम: None
                
                
                Outcome: None
                
                
                प्रभाव: None
                
                
                None
                
            

            
            
जनसंख्या: the presence of dyspepsia in the absence of organic or metabolic causes

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …
            
            

                
                Dose: Glycyrrhiza glabra flavonoid-rich extract
                
                
                बनाम: None
                
                
                Outcome: compatibility with probiotics and digestive enzymes
                
                
                प्रभाव: compatible with all tested strains
                
                
                None
                
            

            
            
जनसंख्या: Probiotic strains and enzymes (in vitro)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence …
            
            

                
                Dose: None
                
                
                बनाम: None
                
                
                Outcome: None
                
                
                प्रभाव: None
                
                
                None
                
            

            
            
जनसंख्या: IBD patients (herbal therapy review)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …
            
            

                
                Dose: 75 mg twice daily
                
                
                बनाम: Placebo
                
                
                Outcome: Functional dyspepsia symptom severity (SFLDQ)
                
                
                प्रभाव: None
                
                
                None
                
            

            
            
जनसंख्या: Adults with functional dyspepsia

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
अध्ययन

    

    

        
150

        
प्रतिभागी

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
ग्रेड

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Current drug discovery …
                        2021
                        
                        16 उद्धरण
                        
                    

                

                
                

                    

                        
                            Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of dietary …
                        2017
                        
                        13 उद्धरण
                        
                    

                

                
                

                    

                        
                            Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Annals of gastroenterology
                        2016
                        
                        41 उद्धरण
                        
                    

                

                
                

                    

                        
                            An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Evidence-based complementary and …
                        2012
                        
                        70 उद्धरण
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
सामान्य रूप से उपयोग की जाने वाली खुराकें

                

                    
                    

                        
general:

                        
380-760 mg DGL extract 3 times daily before meals

                    

                    
                    

                        
gastricsupport:

                        
760 mg before meals and at bedtime

                    

                    
                    

                        
dyspepsiasupport:

                        
380-400 mg chewable tablet 20 minutes before meals, 3 times daily

                    

                    
                

                
                

                    अधिकतम सीमा: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                

                
            

            

            
            

                
अनुसंधान में अध्ययन की गई खुराकें

                

                    

                        
                            

                                खुराक
                                अवधि
                                प्रभाव
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                Glycyrrhiza glabra flavonoid-rich extract
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                75 mg twice daily
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                सेवन का सर्वोत्तम समय: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
रिपोर्ट किए गए दुष्प्रभाव

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild nausea in rare cases
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache (uncommon)
                        
    • 
                        
                        
  • 
                            ⚠
                            If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)
                        
    • 
                        
                    

                

                

                
                

                    
ज्ञात अंतःक्रियाएँ

                    
    
                        
                        
  • 
                            ●
                            Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
                        
    • 
                        
                        
  • 
                            ●
                            Diuretics (if residual glycyrrhizin, additive potassium loss)
                        
    • 
                        
                        
  • 
                            ●
                            Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
                        
    • 
                        
                        
  • 
                            ●
                            Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)
                        
    • 
                        
                    

                

                

                
                

                    

                        सहनीय अधिकतम सेवन: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
                    

                

                
            

            

                कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Deglycyrrhizinated Licorice (DGL) help with Peptic Ulcer Disease?
            
        
        

            Based on 2 studies with 150 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Peptic Ulcer Disease management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Deglycyrrhizinated Licorice (DGL) should I take for Peptic Ulcer Disease?
            
        
        

            Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Deglycyrrhizinated Licorice (DGL)?
            
        
        

            Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Peptic Ulcer Disease?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
इसके लिए अन्य सामग्री Peptic Ulcer Disease

                    

                        
                        
                            Zinc Carnosine
                            B

                        
                        
                    

                

                

                
                

                    
Deglycyrrhizinated Licorice (DGL) अन्य स्वास्थ्य स्थितियों के लिए

                    

                        
                        
                            Functional Dyspepsia
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA अस्वीकरण:
        इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।