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L-Glutamine pour Increased Intestinal Permeability (Leaky Gut)

D

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

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D

En conclusion

Small studies in athletes show glutamine (0.25-0.9 g/kg) may reduce exercise-induced intestinal permeability.

Key Study Findings

Review
Intestinal Barrier Impairment, Preservation, and Repair: An Update.
Dose: None vs: None Outcome: Intestinal barrier preservation and repair Effet: None None

Population: IBD and IBS patients (review)

Other
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.
Dose: None vs: None Outcome: Cholesterol levels Effet: None None

Population: Mouse model

In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None vs: None Outcome: inflammation markers Effet: None None

Population: Mice

Other
Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function.
Dose: None vs: None Outcome: None Effet: None None

Population: None

Systematic Review
Effects of glutamine supplementation on inflammatory bowel disease: A systematic review of clinical trials.
Dose: None vs: Placebo or standard care Outcome: IBD symptom improvement Effet: None None

Population: IBD patients

Controlled Clinical Trial n=43 4 weeks
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with …
Dose: 5 g/d vs: None Outcome: None Effet: None None

Population: IBS patients

Key Statistics

2

Études

80

Participants

Positive

D

Note

Referenced Papers

The Cochrane database … 2016 37 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:
5-15 g/day
ibsdsupport:
5 g three times daily (15 g/day total)
postexercisegut:
0.25-0.9 g/kg before intense exercise
gutbarriersupport:
0.5 g/kg/day (approximately 30-40 g/day for adults)

Limite supérieure : Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Posologies étudiées dans la recherche

Posologie Durée Effet N
None -- Positive --
None -- Positive --
None -- Mixed --
None -- Mixed --
None -- Positive --
5 g/d 4 weeks Positive 43
5 g 8.0 weeks Positive --
None -- Mixed --

Moment optimal de prise : Between meals or before exercise; divide doses throughout the day

Safety & Side Effects

Effets indésirables signalés

  • Mild gastrointestinal discomfort at high doses
  • Headache
  • Dizziness at very high doses
  • Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)

Interactions connues

  • Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
  • Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
  • Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)

Apport maximal tolérable : Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does L-Glutamine help with Increased Intestinal Permeability (Leaky Gut)?
Based on 2 studies with 80 participants, there is preliminary evidence that needs more research that L-Glutamine may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is D (Very Early Research).
How much L-Glutamine should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 5-15 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Glutamine?
Reported side effects may include Mild gastrointestinal discomfort at high doses, Headache, Dizziness at very high doses, Potential glutamate excitotoxicity concerns in neurological conditions (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Glutamine and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 80 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Increased Intestinal Permeability (Leaky Gut)

L-Glutamine pour d'autres pathologies

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.