L-Glutamine pour Irritable Bowel Syndrome (IBS)
CPilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.
En conclusion
Pilot RCTs suggest glutamine (5 g TID) reduces intestinal permeability and IBS-D symptoms in post-infectious IBS. Promising but needs larger trials.
Key Study Findings
Population: animal model of IBS with diarrhea
Population: female rats with water avoidance stress-induced IBS-D model
Population: Male C57BL/6 mice (IBS-D model)
Population: IBD and IBS patients (review)
Population: Mouse model
Population: Mice
Key Statistics
2
Études
150
Participants
Positive
Note
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 5-15 g/day
- ibsdsupport:
- 5 g three times daily (15 g/day total)
- postexercisegut:
- 0.25-0.9 g/kg before intense exercise
- gutbarriersupport:
- 0.5 g/kg/day (approximately 30-40 g/day for adults)
Limite supérieure : Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 | 4 weeks | Positive | 25 |
| None | -- | Mixed | 62 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | 75 |
Moment optimal de prise : Between meals or before exercise; divide doses throughout the day
Safety & Side Effects
Effets indésirables signalés
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Headache
- ⚠ Dizziness at very high doses
- ⚠ Potential glutamate excitotoxicity concerns in neurological conditions (theoretical)
Interactions connues
- ● Lactulose (glutamine may reduce the efficacy of lactulose for hepatic encephalopathy)
- ● Anti-seizure medications (glutamine converts to glutamate; theoretical concern)
- ● Chemotherapy agents (glutamine may protect cancer cells; discuss with oncologist)
Apport maximal tolérable : Generally well-tolerated up to 0.5 g/kg/day; caution above 40 g/day
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does L-Glutamine help with Irritable Bowel Syndrome (IBS)?
How much L-Glutamine should I take for Irritable Bowel Syndrome (IBS)?
Are there side effects of L-Glutamine?
How strong is the evidence for L-Glutamine and Irritable Bowel Syndrome (IBS)?
Related Evidence
Autres ingrédients pour Irritable Bowel Syndrome (IBS)
L-Glutamine pour d'autres pathologies
Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.