Bifidobacterium breve pour Irritable Bowel Syndrome (IBS)
D Recherche Seules des recherches préliminaires existent (études en laboratoire, rapports de cas).Limited data from small studies. Preliminary evidence for symptom improvement.
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D
En conclusion
Limited data from small studies. Preliminary evidence for symptom improvement.
Key Study Findings
Review
Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases.
Dose: None
vs: None
Outcome: None
Effet: None
None
Population: None
Other
n=1098
8 weeks
Open-label
A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of …
Dose: None
vs: None (single-arm open-label)
Outcome: Treatment success for abdominal pain and bloating
Effet: 73% pain, 81.9% bloating success at T1
<0.001
Population: IBS patients from 52 Italian gastroenterologists
Randomized Controlled Trial
n=61
8 weeks
Double-blind
Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with …
Dose: None
vs: Placebo
Outcome: IBS-SSS symptom severity score change
Effet: None
None
Population: Patients with moderate-severe diarrhea-predominant IBS
Randomized Controlled Trial
4 weeks
Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …
Dose: 2 g
vs: Placebo
Outcome: Constipation symptoms
Effet: None
P = 0.005
Population: IBS patients
Review
Postbiotics: A new member in the biotics family.
Dose: None
vs: None
Outcome: Clinical applications overview
Effet: None
None
Population: General population (review)
In Vitro
Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal …
Dose: None
vs: None
Outcome: Colitis severity
Effet: None
None
Population: Crohn's disease patients
Key Statistics
2
Études
150
Participants
↑
Positive
D
Note
Referenced Papers
Microbiome research reports
2025
16 citations
Beneficial microbes
2025
Frontiers in nutrition
2025
The Yale journal …
2024
5 citations
Journal of neurogastroenterology …
2024
4 citations
Archivos argentinos de …
2024
3 citations
Cureus
2024
1 citations
Journal of translational …
2023
30 citations
Nutrients
2023
19 citations
Journal of neurogastroenterology …
2022
21 citations
Journal of microbiology …
2022
15 citations
Scientific reports
2022
14 citations
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 citations
Journal of clinical …
2015
62 citations
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Meta-Analysis
Revista espanola de …
2013
102 citations
Journal of clinical …
2012
207 citations
PloS one
2012
31 citations
Beneficial microbes
2011
89 citations
The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat.
Other
Neurogastroenterology and motility
2010
213 citations
BMC gastroenterology
2010
91 citations
Alimentary pharmacology & …
2007
102 citations
Asia Pacific journal …
2006
Alimentary pharmacology & …
2005
398 citations
Journal of clinical …
2004
205 citations
Research in microbiology
2001
201 citations
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 1-10 billion CFU/day
- adultgisupport:
- 5-10 billion CFU/day
- neonatalsupport:
- 1-5 billion CFU/day (as directed by pediatrician)
Limite supérieure : Well-tolerated up to 10 billion CFU/day in clinical trials
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | 8 weeks | Positive | 1098 |
| None | 8 weeks | Neutral | 61 |
| 2 g | 4 weeks | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Serum-derived bovine immunoglobulin (SBI) | -- | Positive | -- |
| None | -- | Positive | -- |
Moment optimal de prise : Before meals or on empty stomach; for infants, mix with breast milk or formula
Safety & Side Effects
Effets indésirables signalés
- ⚠ Mild gas during initial use
- ⚠ Occasional loose stools in infants (transient)
- ⚠ Rare abdominal discomfort
- ⚠ Very rare: bacteremia in immunocompromised individuals
Interactions connues
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
Apport maximal tolérable : Well-tolerated up to 10 billion CFU/day in clinical trials
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Bifidobacterium breve help with Irritable Bowel Syndrome (IBS)?
Based on 2 studies with 150 participants, there is preliminary evidence that needs more research that Bifidobacterium breve may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is D (Very Early Research).
How much Bifidobacterium breve should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium breve?
Reported side effects may include Mild gas during initial use, Occasional loose stools in infants (transient), Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium breve and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
Autres ingrédients pour Irritable Bowel Syndrome (IBS)
References
- [1] Fabiana Bocchio et al.. Microbiome Res Rep. 2025. Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases. doi:10.20517/mrr.2024.52 PubMed
- [2] L Drago et al.. Benef Microbes. 2025. A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of irritable bowel syndrome in adults. doi:10.1163/18762891-bja00097 PubMed
- [3] Ida Marie Bruun Grønbæk et al.. Front Nutr. 2025. Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with diarrhoea-predominant irritable bowel syndrome: results … doi:10.3389/fnut.2025.1701341 PubMed
- [4] Mattia Tinazzi et al.. Yale J Biol Med. 2024. Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … doi:10.59249/JOMF5336 PubMed
- [5] Young Hoon Chang et al.. J Neurogastroenterol Motil. 2024. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. doi:10.5056/jnm23036 PubMed
- [6] María Del C Toca et al.. Arch Argent Pediatr. 2024. Postbiotics: A new member in the biotics family. doi:10.5546/aap.2023-10168.eng PubMed
- [7] Sabine Hazan et al.. Cureus. 2024. Gut Microbiome Alterations Following Oral Serum-Derived Bovine Immunoglobulin Administration in the Management of Dysbiosis. doi:10.7759/cureus.75884 PubMed
- [8] Han Chen et al.. J Transl Med. 2023. Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data. doi:10.1186/s12967-023-03953-7 PubMed
- [9] Xinqi Chen et al.. Nutrients. 2023. Dose-Response Efficacy and Mechanisms of Orally Administered Bifidobacterium breve CCFM683 on IMQ-Induced Psoriasis in Mice. doi:10.3390/nu15081952 PubMed
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- [11] Yae Jin Choi et al.. J Microbiol Biotechnol. 2022. Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children. doi:10.4014/jmb.2206.06023 PubMed
- [12] Edgar Torres-Maravilla et al.. Sci Rep. 2022. Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome. doi:10.1038/s41598-022-21746-8 PubMed
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- [14] Hyuk Yoon et al.. J Clin Biochem Nutr. 2015. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … doi:10.3164/jcbn.15-14 PubMed
- [15] María Ortiz-Lucas et al.. Rev Esp Enferm Dig. 2013. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. doi:10.4321/s1130-01082013000100005 PubMed
- [16] Bong Ki Cha et al.. J Clin Gastroenterol. 2012. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … doi:10.1097/MCG.0b013e31823712b1 PubMed
- [17] Eoin Barrett et al.. PLoS One. 2012. Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel … doi:10.1371/journal.pone.0048159 PubMed
- [18] E O'Sullivan et al.. Benef Microbes. 2011. BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels? doi:10.3920/BM2011.0015 PubMed
- [19] D P McKernan et al.. Neurogastroenterol Motil. 2010. The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat. doi:10.1111/j.1365-2982.2010.01520.x PubMed
- [20] Anna Lyra et al.. BMC Gastroenterol. 2010. Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. doi:10.1186/1471-230X-10-110 PubMed
- [21] K Kajander et al.. Aliment Pharmacol Ther. 2007. Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. doi:10.1111/j.1365-2036.2007.03391.x PubMed
- [22] Kajsa Kajander et al.. Asia Pac J Clin Nutr. 2006. Clinical studies on alleviating the symptoms of irritable bowel syndrome. PubMed
- [23] K Kajander et al.. Aliment Pharmacol Ther. 2005. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. doi:10.1111/j.1365-2036.2005.02579.x PubMed
- [24] Alfredo Saggioro. J Clin Gastroenterol. 2004. Probiotics in the treatment of irritable bowel syndrome. doi:10.1097/01.mcg.0000129271.98814.e2 PubMed
- [25] P Brigidi et al.. Res Microbiol. 2001. Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome … doi:10.1016/s0923-2508(01)01254-2 PubMed
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