Vitamin D لـ Irritable Bowel Syndrome (IBS)
CLimited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
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C
الخلاصة
Limited studies suggest vitamin D supplementation may improve IBS symptoms, particularly in deficient individuals. Mechanism via VDR-mediated immune modulation.
Key Study Findings
Review
Early Evidence Indicates Vitamin D Improves Symptoms of Irritable Bowel Syndrome: Nursing Implications and Future …
Dose: None
مقابل: None
Outcome: IBS symptom improvement with vitamin D supplementation
التأثير: None
None
المجتمع المدروس: individuals with irritable bowel syndrome
Systematic Review
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews …
Dose: None
مقابل: Various
Outcome: IBS symptom improvement
التأثير: Probiotics abdominal pain RR 4.04 (2.36-6.92)
None
المجتمع المدروس: Adult IBS patients
Meta-Analysis
Double-blind
The effects of vitamin D intake and status on symptom severity and quality-of-life in adults …
Dose: 3,000 IU daily to 50,000 IU bi-weekly
مقابل: Placebo
Outcome: IBS symptom severity and quality of life
التأثير: MD 20.33 ng/mL [12.91, 27.74] for 25(OH)D; QoL 3.1
None
المجتمع المدروس: Adults with IBS and deficient/insufficient vitamin D
Review
Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review.
Dose: None
مقابل: None
Outcome: Risk of developing Parkinson's disease
التأثير: None
None
المجتمع المدروس: General population (narrative review of PD risk factors)
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
مقابل: None
Outcome: Micronutrient deficiency management in pediatric IBD
التأثير: None
None
المجتمع المدروس: Children with inflammatory bowel disease (review)
Review
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Dose: None
مقابل: None
Outcome: IBS symptom relief and pathophysiology modulation
التأثير: None
None
المجتمع المدروس: Patients with irritable bowel syndrome (review)
Key Statistics
3
الدراسات
400
المشاركون
↑
Positive
C
التقييم
Referenced Papers
Gastroenterology nursing : …
None
4 اقتباسات
Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical …
Systematic Review
Nutrition reviews
2025
10 اقتباسات
Nutrients
2025
7 اقتباسات
Arquivos de neuro-psiquiatria
2025
6 اقتباسات
Critical reviews in …
2025
6 اقتباسات
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.
Review
Nutrients
2025
4 اقتباسات
Nutrients
2025
4 اقتباسات
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2025
3 اقتباسات
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Medicina (Kaunas, Lithuania)
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Nutrients
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47 اقتباسات
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BMC gastroenterology
2024
8 اقتباسات
Nutrients
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5 اقتباسات
Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome.
Other
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4 اقتباسات
Minerva gastroenterology
2024
4 اقتباسات
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2023
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Nutrition and health
2023
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Neurogastroenterology and motility
2023
4 اقتباسات
Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and …
Systematic Review
Biological research for …
2023
3 اقتباسات
Irritable bowel syndrome and endometriosis: diagnosis, similarities, and nutritional management.
Other
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2023
2 اقتباسات
Nutrition journal
2023
Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis.
Meta-Analysis
Journal of gastroenterology …
2022
30 اقتباسات
Association between irritable bowel syndrome and micronutrients: A systematic review.
Systematic Review
Journal of gastroenterology …
2022
29 اقتباسات
The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis.
Meta-Analysis
Nutrition journal
2022
28 اقتباسات
The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome …
Meta-Analysis
Nutrients
2022
24 اقتباسات
PloS one
2022
10 اقتباسات
Nutricion hospitalaria
2022
9 اقتباسات
Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults.
Other
Nutrients
2022
7 اقتباسات
Journal of gastroenterology …
2022
4 اقتباسات
Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review.
Systematic Review
Nutrients
2021
16 اقتباسات
Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome.
Other
Journal of gastroenterology …
2021
10 اقتباسات
Zhongguo dang dai …
2021
The journal of …
2020
294 اقتباسات
The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis.
Meta-Analysis
Osteoporosis international : …
2020
14 اقتباسات
Cureus
2020
10 اقتباسات
Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D.
Review
Expert review of …
2019
33 اقتباسات
Medicine
2019
4 اقتباسات
Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what …
Systematic Review
European journal of …
2018
39 اقتباسات
Saudi journal of …
2018
38 اقتباسات
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2017
280 اقتباسات
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2017
157 اقتباسات
PloS one
2017
38 اقتباسات
PloS one
2017
5 اقتباسات
World journal of …
2016
238 اقتباسات
Nutrients
2016
55 اقتباسات
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Review
Digestive diseases (Basel, …
2016
41 اقتباسات
Clinics in dermatology
2016
19 اقتباسات
World journal of …
2015
62 اقتباسات
Oman medical journal
2015
56 اقتباسات
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
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225 اقتباسات
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Meta-Analysis
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23 اقتباسات
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 600-800 IU/day (RDA)
- ibdsupport:
- 1,000-4,000 IU/day (target serum 25(OH)D >30 ng/mL)
- deficiencycorrection:
- 50,000 IU/week for 8 weeks, then 1,000-4,000 IU/day maintenance
الحد الأعلى: 4,000 IU/day (100 mcg); higher doses under medical supervision only
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 3,000 IU daily to 50,000 IU bi-weekly | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 240 |
أفضل وقت للتناول: With a meal containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion)
- ⚠ Kidney stones with excessive long-term supplementation
- ⚠ Constipation
- ⚠ Metallic taste
التفاعلات المعروفة
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
الحد الأقصى المسموح به: 4,000 IU/day (100 mcg); higher doses under medical supervision only
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Vitamin D help with Irritable Bowel Syndrome (IBS)?
Based on 3 studies with 400 participants, there is limited but promising evidence that Vitamin D may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is C (Some Evidence).
How much Vitamin D should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness, confusion), Kidney stones with excessive long-term supplementation, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Irritable Bowel Syndrome (IBS)
Vitamin D لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.