Bifidobacterium longum لـ Irritable Bowel Syndrome (IBS)
B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.RCTs demonstrate significant reduction in IBS composite symptom score versus placebo. Particular benefit for bloating and abdominal distension. Marketed as Alflorex/Align.
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B
الخلاصة
RCTs demonstrate significant reduction in IBS composite symptom score versus placebo. Particular benefit for bloating and abdominal distension. Marketed as Alflorex/Align.
Key Study Findings
Meta-Analysis
n=3154
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …
Dose: None
مقابل: placebo
Outcome: quality of life, depression, and anxiety in IBS …
التأثير: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression)
None
المجتمع المدروس: patients with irritable bowel syndrome
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
مقابل: placebo
Outcome: improvement in key IBS symptoms
التأثير: None
None
المجتمع المدروس: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Controlled Clinical Trial
n=51
12 weeks
Open-label
Targeted probiotic therapy in irritable bowel syndrome: a clinical evaluation on Clostridium butyricum CBM588 and …
Dose: None
مقابل: Pre-treatment baseline
Outcome: IBS-SSS score reduction
التأثير: None
None
المجتمع المدروس: IBS-D and IBS-C patients
Observational Study
n=37
8 weeks
Open-label
An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms …
Dose: None
مقابل: None
Outcome: Total IBS symptom score (TISS)
التأثير: 43.4% TISS reduction; >60% >=30% responders
None
المجتمع المدروس: Adults with IBS (Rome IV criteria)
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
مقابل: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
التأثير: None
<0.001
المجتمع المدروس: IBS patients (28) and asymptomatic controls (7)
Review
The Role and the Regulation of NLRP3 Inflammasome in Irritable Bowel Syndrome: A Narrative Review.
Dose: None
مقابل: None
Outcome: IBS symptom management via NLRP3 inhibition
التأثير: None
None
المجتمع المدروس: Patients with IBS (narrative review)
Key Statistics
4
الدراسات
600
المشاركون
↑
Positive
B
التقييم
Referenced Papers
European journal of …
2026
Journal of clinical …
2026
An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome.
Observational
Probiotics and antimicrobial …
2025
6 اقتباسات
The Role and the Regulation of NLRP3 Inflammasome in Irritable Bowel Syndrome: A Narrative Review.
Review
Microorganisms
2025
4 اقتباسات
International journal of …
2025
4 اقتباسات
Frontiers in medicine
2025
3 اقتباسات
Gut microbes
2024
22 اقتباسات
Nutrients
2024
13 اقتباسات
Microbiology spectrum
2024
9 اقتباسات
Journal of neurogastroenterology …
2024
4 اقتباسات
Journal of clinical …
2024
4 اقتباسات
Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome.
Other
Nutrients
2024
4 اقتباسات
Gut microbes
2024
Journal of translational …
2023
30 اقتباسات
Food & function
2023
18 اقتباسات
Neurogastroenterology and motility
2023
16 اقتباسات
Journal of gastroenterology …
2023
11 اقتباسات
Terapevticheskii arkhiv
2023
3 اقتباسات
Voprosy pitaniia
2023
Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome.
Observational
World journal of …
2022
27 اقتباسات
Journal of neurogastroenterology …
2022
21 اقتباسات
Journal of microbiology …
2022
15 اقتباسات
Computational and structural …
2022
15 اقتباسات
Scientific reports
2022
14 اقتباسات
Terapevticheskii arkhiv
2022
6 اقتباسات
Microorganisms
2021
47 اقتباسات
Nutrients
2021
36 اقتباسات
Clinical nutrition ESPEN
2021
11 اقتباسات
Voprosy pitaniia
2021
3 اقتباسات
Gastroenterology
2020
290 اقتباسات
European journal of …
2020
80 اقتباسات
Nutrients
2020
78 اقتباسات
Nutrients
2020
59 اقتباسات
Gut microbes
2020
36 اقتباسات
Journal of clinical …
2020
31 اقتباسات
The Cochrane database …
2020
14 اقتباسات
Nutrients
2019
114 اقتباسات
Beneficial microbes
2019
31 اقتباسات
Journal of neurogastroenterology …
2018
121 اقتباسات
Saudi journal of …
2018
41 اقتباسات
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 اقتباسات
Gastroenterology
2018
23 اقتباسات
Gastroenterology
2017
684 اقتباسات
The Australian and …
2017
280 اقتباسات
Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis.
Meta-Analysis
Current medical research …
2017
86 اقتباسات
Journal of gastroenterology …
2017
32 اقتباسات
Current medical research …
2017
21 اقتباسات
PloS one
2016
83 اقتباسات
Artificial cells, nanomedicine, …
2016
16 اقتباسات
Journal of gastroenterology …
2014
164 اقتباسات
Orvosi hetilap
2014
6 اقتباسات
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Meta-Analysis
Revista espanola de …
2013
102 اقتباسات
Journal of clinical …
2012
207 اقتباسات
Acta bio-medica : …
2006
41 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1-10 billion CFU/day
- ibssupport:
- 1 billion CFU/day (35624 strain, marketed as Alflorex/Align)
الحد الأعلى: Well-tolerated up to 10 billion CFU/day in clinical trials
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | 3154 |
| None | -- | Positive | -- |
| None | 12 weeks | Positive | 51 |
| None | 8 weeks | Positive | 37 |
| 1e6 CFU/mL | -- | Positive | 35 |
| None | -- | Positive | -- |
| None | 12 weeks | Positive | -- |
| 1x10^10 CFU daily | 6 weeks | Positive | 35 |
أفضل وقت للتناول: On an empty stomach or before meals
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
التفاعلات المعروفة
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
الحد الأقصى المسموح به: Well-tolerated up to 10 billion CFU/day in clinical trials
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Bifidobacterium longum help with Irritable Bowel Syndrome (IBS)?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium longum may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium longum should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium longum?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium longum and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Irritable Bowel Syndrome (IBS)
References
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