Lactobacillus rhamnosus GG لـ Irritable Bowel Syndrome (IBS)
B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.
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B
الخلاصة
Several RCTs show improvement in IBS symptoms, particularly bloating and abdominal pain. Effect strongest in IBS-D subtype. Results not uniform across all IBS subtypes.
Key Study Findings
Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None
مقابل: placebo
Outcome: improvement in key IBS symptoms
التأثير: None
None
المجتمع المدروس: patients with IBS from 32 RCTs evaluating 10 probiotic strains
Randomized Controlled Trial
3 weeks
Double-blind
Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review …
Dose: None
مقابل: Placebo
Outcome: Pain outcomes
التأثير: None
None
المجتمع المدروس: IBS patients
Systematic Review
n=3
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic …
Dose: None
مقابل: None
Outcome: Abdominal pain frequency/intensity, constipation
التأثير: None
None
المجتمع المدروس: Children with FAPD or functional constipation
Systematic Review
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Dose: various probiotic strains
مقابل: placebo
Outcome: IBS symptom improvement in children
التأثير: LGG showed benefit in some studies
None
المجتمع المدروس: Children with IBS
Review
Probiotic Bacterial and Fungal Strains: Claims with Evidence.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: Various populations (probiotic claims review)
Review
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: IBD patients
Key Statistics
8
الدراسات
1200
المشاركون
↑
Positive
B
التقييم
Referenced Papers
Journal of clinical …
2026
Nutrients
2024
5 اقتباسات
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 اقتباسات
Digestive diseases (Basel, …
2016
37 اقتباسات
Probiotics for Irritable Bowel Syndrome: Clinical Data in Children.
Systematic Review
Journal of pediatric …
2016
19 اقتباسات
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 اقتباسات
Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
Review
Nutrition in clinical …
2015
31 اقتباسات
BMC gastroenterology
2010
91 اقتباسات
Alimentary pharmacology & …
2007
102 اقتباسات
Asia Pacific journal …
2006
45 اقتباسات
Asia Pacific journal …
2006
Alimentary pharmacology & …
2005
398 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 10-20 billion CFU/day
- ibssupport:
- 10 billion CFU/day for 4-8 weeks
- aadprevention:
- 10-20 billion CFU/day (start with antibiotic, continue 7 days after)
الحد الأعلى: Generally well-tolerated up to 40 billion CFU/day in clinical trials
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 3 weeks | Positive | -- |
| None | -- | Mixed | 3 |
| various probiotic strains | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | 26.0 weeks | Mixed | -- |
أفضل وقت للتناول: On an empty stomach or 30 minutes before meals for optimal survival
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
- ⚠ Rare reports of bacteremia in severely immunocompromised individuals
- ⚠ Occasional loose stools during adjustment period
- ⚠ Very rare: systemic infection in critically ill patients with central venous catheters
التفاعلات المعروفة
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (theoretical risk of infection in immunocompromised patients)
- ● Antifungals (no known interaction but may affect gut flora balance)
الحد الأقصى المسموح به: Generally well-tolerated up to 40 billion CFU/day in clinical trials
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Lactobacillus rhamnosus GG help with Irritable Bowel Syndrome (IBS)?
Based on 8 studies with 1,200 participants, there is moderate evidence from clinical studies that Lactobacillus rhamnosus GG may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).
How much Lactobacillus rhamnosus GG should I take for Irritable Bowel Syndrome (IBS)?
Studies have used various dosages. A commonly studied range is 10-20 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus rhamnosus GG?
Reported side effects may include Mild gas and bloating during initial use (usually resolves in 1-2 weeks), Rare reports of bacteremia in severely immunocompromised individuals, Occasional loose stools during adjustment period, Very rare: systemic infection in critically ill patients with central venous catheters. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus rhamnosus GG and Irritable Bowel Syndrome (IBS)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Irritable Bowel Syndrome (IBS)
Lactobacillus rhamnosus GG لحالات أخرى
References
- [1] Roman Maslennikov et al.. J Clin Med. 2026. Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. doi:10.3390/jcm15031152 PubMed
- [2] Silvia Salvatore et al.. Nutrients. 2024. Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. doi:10.3390/nu16030349 PubMed
- [3] Carrie A M Wegh et al.. J Clin Gastroenterol. 2018. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. doi:10.1097/MCG.0000000000001054 PubMed
- [4] Hania Szajewska et al.. Dig Dis. 2016. Probiotic Bacterial and Fungal Strains: Claims with Evidence. doi:10.1159/000443359 PubMed
- [5] Eleonora Giannetti et al.. J Pediatr Gastroenterol Nutr. 2016. Probiotics for Irritable Bowel Syndrome: Clinical Data in Children. doi:10.1097/MPG.0000000000001220 PubMed
- [6] Sylvia Cruchet et al.. Paediatr Drugs. 2015. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. doi:10.1007/s40272-015-0124-6 PubMed
- [7] Danielle Barnes et al.. Nutr Clin Pract. 2015. Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. doi:10.1177/0884533615610081 PubMed
- [8] Anna Lyra et al.. BMC Gastroenterol. 2010. Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. doi:10.1186/1471-230X-10-110 PubMed
- [9] K Kajander et al.. Aliment Pharmacol Ther. 2007. Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. doi:10.1111/j.1365-2036.2007.03391.x PubMed
- [10] Seppo Salminen et al.. Asia Pac J Clin Nutr. 2006. Intestinal colonisation, microbiota and future probiotics? PubMed
- [11] Kajsa Kajander et al.. Asia Pac J Clin Nutr. 2006. Clinical studies on alleviating the symptoms of irritable bowel syndrome. PubMed
- [12] K Kajander et al.. Aliment Pharmacol Ther. 2005. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. doi:10.1111/j.1365-2036.2005.02579.x PubMed
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.