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GutCited

Vitamin A
Vitamin A

vitamin

别名: Retinol, Retinyl Palmitate, Beta-Carotene (provitamin A), Retinoic Acid

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About





            

                
维生素A通过视黄酸信号通路，在维持肠道上皮细胞的正常分化与更新中发挥关键作用。它支持杯状细胞的黏液分泌——黏液是构成肠道屏障的重要成分——并参与分泌型IgA在黏膜表面的转运过程。研究表明，维生素A补充可能有助于支持肠道屏障完整性及免疫防御功能，尤其对于维生素A缺乏的人群效果更为显著。维生素A被认为是维护肠道黏膜健康的重要营养素。

            

        

        

        
        
        

            

  
How It Works





            

                
Maintains intestinal epithelial cell differentiation and turnover via retinoic acid signaling through RAR/RXR nuclear receptors; supports goblet cell mucus production forming the protective mucus layer; required for secretory IgA transport across mucosal surfaces; modulates Th17/Treg balance in gut-associated lymphoid tissue (GALT).

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Increased Intestinal Permeability (Leaky Gut)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    250
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Acute Diarrhea
                                    
                                
                                
                                    D

                                
                                
                                    3
                                
                                
                                    500
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Hepatotoxicity at chronic high doses of preformed vitamin A
                
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                    Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
                
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                    Nausea, headache, and dizziness
                
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                    Bone density reduction with long-term excess
                
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Drug & Supplement Interactions





            
    
                
                
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                    Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
                
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                    Orlistat (reduces absorption of fat-soluble vitamins)
                
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                    Alcohol (increases hepatotoxicity risk of vitamin A)
                
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                    Tetracycline antibiotics (increased risk of intracranial pressure)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin D
                    
                
                
            

        

        
    


    
    












    

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