Lactobacillus acidophilus 用于 Irritable Bowel Syndrome (IBS)

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

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结论

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Key Study Findings

Randomized Controlled Trial n=200 12 weeks Double-blind

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable …

Dose: None vs: placebo Outcome: IBS-Global Improvement Scale response 效果: 19.3% vs 8.9% response at day 28 p=0.048

研究人群: adults with non-constipated irritable bowel syndrome

Meta-Analysis n=3154

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable …

Dose: None vs: placebo Outcome: quality of life, depression, and anxiety in IBS … 效果: SUCRA=89.7% (B. longum for QoL); SUCRA=95.6% (probiotic combo for depression) None

研究人群: patients with irritable bowel syndrome

Randomized Controlled Trial n=61 12 weeks Double-blind

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel …

Dose: None vs: Placebo Outcome: IBS-SSS (100-point reduction) 效果: 45% active vs 33% placebo (P=0.42) P=0.42

研究人群: IBD patients with IBS symptoms in remission

Randomized Controlled Trial 4 weeks

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group …

Dose: 2 g vs: Placebo Outcome: Constipation symptoms 效果: None P = 0.005

研究人群: IBS patients

Randomized Controlled Trial 12 weeks Double-blind

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides …

Dose: None vs: Placebo Outcome: Quality of life 效果: None p = 0.023

研究人群: IBS patients

Other

Computational prediction of new therapeutic effects of probiotics.

Dose: None vs: None Outcome: Colitis severity 效果: None None

研究人群: Crohn's disease patients

Key Statistics

研究数量

350

受试者

↑

Positive

等级

Referenced Papers

Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized … RCT

Journal of gastroenterology … 2026 1 次引用

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review … Meta-Analysis

European journal of … 2026

Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel diseases in absence of inflammation … Other

World journal of … 2025 2 次引用

A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. RCT

Scientific reports 2024 20 次引用

Computational prediction of new therapeutic effects of probiotics. Other

Scientific reports 2024 10 次引用

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro … Other

The Yale journal … 2024 5 次引用

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel … Other

Journal of clinical … 2024 4 次引用

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Other

Journal of neurogastroenterology … 2024 4 次引用

A Synbiotic Combining Chitin-Glucan and Lactobacillus acidophilus NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an … Other

International journal of … 2024 2 次引用

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Meta-Analysis

Nutrients 2023 33 次引用

Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis. Other

Anaerobe 2023 14 次引用

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 次引用

Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Other

Minerva pediatrics 2023 2 次引用

[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea … Other

Voprosy pitaniia 2023

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: … Other

Journal of neurogastroenterology … 2022 21 次引用

Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis. Systematic Review

Nutrients 2022 19 次引用

Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study. Other

Gastroenterology research and … 2022 15 次引用

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Review

Microorganisms 2021 47 次引用

Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Other

Acta gastro-enterologica Belgica 2021 14 次引用

Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. RCT

Nutrients 2020 99 次引用

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant … RCT

Nutrients 2020 78 次引用

A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. RCT

Digestive and liver … 2020 28 次引用

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future … Review

Cellular and molecular … 2020 4 次引用

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Other

Probiotics and antimicrobial … 2019 43 次引用

Effects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model. Other

BMC complementary and … 2019 24 次引用

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Review

Diseases (Basel, Switzerland) 2018 50 次引用

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. RCT

Beneficial microbes 2018 48 次引用

Lactobacillus acidophilus and Bifidobacterium longum supernatants upregulate the serotonin transporter expression in intestinal epithelial cells. Other

Saudi journal of … 2018 41 次引用

Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial. RCT

Cellular and molecular … 2017 9 次引用

Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. RCT

World journal of … 2016 99 次引用

Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of … RCT

Journal of dairy … 2016 67 次引用

Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a … Other

Journal of clinical … 2015 62 次引用

Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. RCT

Journal of gastroenterology … 2014 164 次引用

[Correlation of the microbiota and intestinal mucosa in the pathophysiology and treatment of irritable bowel, irritable eye, and irritable mind … Review

Orvosi hetilap 2014 6 次引用

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Meta-Analysis

Revista espanola de … 2013 102 次引用

Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. RCT

Scandinavian journal of … 2013 74 次引用

A meta-analysis of probiotic efficacy for gastrointestinal diseases. Meta-Analysis

PloS one 2012 445 次引用

The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, … RCT

Journal of clinical … 2012 207 次引用

[Probiotic supplement (Lactobacillus acidophilus and bulgaricus) utility in the treatment of irritable bowel syndrome]. RCT

Revista de gastroenterologia … 2012

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional … RCT

Journal of clinical … 2011 163 次引用

Probiotics in irritable bowel syndrome: underachievers or underpowered? Other

Alimentary pharmacology & … 2010 4 次引用

B-cell activation in patients with irritable bowel syndrome (IBS). Other

Neurogastroenterology and motility 2009 81 次引用

Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Other

Gut and liver 2009 77 次引用

Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome. RCT

Digestive diseases and … 2008 160 次引用

Probiotics in functional gastrointestinal disorders: what are the facts? Review

Current opinion in … 2008 68 次引用

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Other

Nature medicine 2007 774 次引用

Treatment of irritable bowel syndrome. A case control experience. Other

Minerva gastroenterologica e … 2006 22 次引用

Bacteriotherapy using fecal flora: toying with human motions. Review

Journal of clinical … 2004 298 次引用

Probiotics in the treatment of irritable bowel syndrome. RCT

Journal of clinical … 2004 205 次引用

Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. RCT

The American journal … 1983 78 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 1-10 billion CFU/day
ibssupport:: 10 billion CFU/day for 4-8 weeks
lactosesupport:: 1-2 billion CFU with dairy consumption

上限： Generally well-tolerated up to 20 billion CFU/day

研究中使用的剂量

剂量	持续时间	效果	N
None	12 weeks	Positive	200
None	--	Positive	3154
None	12 weeks	Neutral	61
2 g	4 weeks	Mixed	--
None	12 weeks	Positive	--
None	--	Neutral	--
10^9 CFU L. acidophilus LA-5 + L. paracasei daily	12 weeks	Positive	110
None	--	Positive	--

最佳服用时间： On an empty stomach or before meals; may also be taken with dairy

Safety & Side Effects

已报告的副作用

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains)
⚠ Very rare: bacteremia in immunocompromised individuals

已知相互作用

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Sulfasalazine (may affect bacterial metabolism)

可耐受最高摄入量： Generally well-tolerated up to 20 billion CFU/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Lactobacillus acidophilus help with Irritable Bowel Syndrome (IBS)?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus acidophilus may support Irritable Bowel Syndrome (IBS) management. Our evidence grade is B (Good Evidence).

How much Lactobacillus acidophilus should I take for Irritable Bowel Syndrome (IBS)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus acidophilus?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare allergic reactions in dairy-sensitive individuals (dairy-cultured strains), Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus acidophilus and Irritable Bowel Syndrome (IBS)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Irritable Bowel Syndrome (IBS)

Peppermint Oil A Lactobacillus rhamnosus GG B Psyllium Husk B Lactobacillus plantarum B Partially Hydrolyzed Guar Gum (PHGG) B Bifidobacterium longum B

快速结论

Improves intestinal transit time and reduces constipation symptoms in IBS-C. Fecal pH decreases indicating improved fermentation. Best evidence for L. acidophilus NCFM strain.

Evidence Strength72%

High confidence

研究分析

RCT (17)Meta (4)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Irritable Bowel Syndrome (IBS)

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