Bifidobacterium lactis 用于 Chronic Constipation
BDose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
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B
结论
Dose-dependently reduces whole gut transit time (WGTT). Higher dose (17.2 billion CFU) showed 31% reduction in WGTT. Also reduces functional GI symptoms.
Key Study Findings
Randomized Controlled Trial
8 weeks
Double-blind
Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, …
Dose: None
vs: Placebo
Outcome: Complete spontaneous bowel movements (CSBMs)
效果: None
None
研究人群: Adults with functional constipation (Rome III)
Randomized Controlled Trial
n=67
4 weeks
Double-blind
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with …
Dose: None
vs: Placebo
Outcome: Weekly spontaneous bowel movements
效果: 4.94 vs 3.00 (P<0.001)
P<0.001
研究人群: Older adults >=60 with functional constipation (Rome IV)
Randomized Controlled Trial
n=35
12 weeks
Double-blind
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable …
Dose: None
vs: Placebo
Outcome: Gut barrier function (zonulin levels)
效果: Zonulin -19.5 ng/mL at week 16
p=0.0002 wk16; p=0.0053 grp
研究人群: IBS without constipation patients
Review
An update on probiotics in paediatrics.
Dose: None
vs: None
Outcome: GI disorder outcomes in paediatrics
效果: None
None
研究人群: Paediatric patients with GI disorders
In Vitro
n=35
A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum …
Dose: 1e6 CFU/mL
vs: IBS supernatants without probiotic
Outcome: Caco-2 paracellular permeability
效果: None
<0.001
研究人群: IBS patients (28) and asymptomatic controls (7)
Randomized Controlled Trial
n=128
2 weeks
Double-blind
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
Dose: 0.5 mL daily for 14 days
vs: Placebo
Outcome: Fever duration (days)
效果: RR 0.64 (95% CI 0.51-0.80)
None
研究人群: Children 28 days-4 years with fever and URTI
Key Statistics
4
研究数量
600
受试者
↑
Positive
B
等级
Referenced Papers
JAMA network open
2025
13 次引用
Nutrients
2025
7 次引用
International journal of …
2025
4 次引用
Molecular nutrition & …
2025
2 次引用
The journal of …
2025
Current opinion in …
2025
JAMA network open
2024
9 次引用
European journal of …
2024
9 次引用
Gut microbes
2023
143 次引用
Journal of clinical …
2023
9 次引用
Clinical nutrition (Edinburgh, …
2022
42 次引用
Frontiers in nutrition
2022
24 次引用
Frontiers in nutrition
2022
22 次引用
Bifidobacterium lactis BL-99 modulates intestinal inflammation and functions in zebrafish models.
Other
PloS one
2022
21 次引用
Medicine
2022
14 次引用
Frontiers in microbiology
2022
4 次引用
Medicine
2021
8 次引用
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Meta-Analysis
Clinical nutrition (Edinburgh, …
2020
94 次引用
Beneficial microbes
2020
22 次引用
Arquivos de gastroenterologia
2020
7 次引用
Alimentary pharmacology & …
2019
59 次引用
Probiotics and antimicrobial …
2019
43 次引用
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Systematic Review
Journal of clinical …
2018
34 次引用
Nutrients
2018
28 次引用
The Turkish journal …
2017
29 次引用
Pediatric gastroenterology, hepatology …
2017
27 次引用
Frontiers in neuroscience
2017
14 次引用
Korean journal for …
2017
7 次引用
The Turkish journal …
2016
63 次引用
The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts.
Systematic Review
Paediatric drugs
2015
122 次引用
The American journal …
2014
284 次引用
Nutrition journal
2014
75 次引用
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials.
Meta-Analysis
World journal of …
2013
111 次引用
Arquivos de gastroenterologia
2013
49 次引用
Georgian medical news
2013
World journal of …
2012
55 次引用
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'.
Other
Nutrition journal
2012
51 次引用
Scandinavian journal of …
2011
187 次引用
Journal of clinical …
2011
163 次引用
Pediatrics
2011
101 次引用
Systematic review of randomised controlled trials: probiotics for functional constipation.
Systematic Review
World journal of …
2010
276 次引用
Alimentary pharmacology & …
2009
333 次引用
BMC pediatrics
2009
46 次引用
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
RCT
World journal of …
2008
163 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 1-10 billion CFU/day
- immunesupport:
- 5-10 billion CFU/day
- constipationsupport:
- 17.2 billion CFU/day (HN019 strain, optimal dose)
上限： Well-tolerated up to 17.2 billion CFU/day in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | 8 weeks | Neutral | -- |
| None | 4 weeks | Positive | 67 |
| None | 12 weeks | Positive | 35 |
| None | -- | Positive | -- |
| 1e6 CFU/mL | -- | Positive | 35 |
| 0.5 mL daily for 14 days | 2 weeks | Positive | 128 |
| None | 2 weeks | Negative | 117 |
| 10 g | 4 weeks | Positive | -- |
最佳服用时间： With or without food; morning dosing may be optimal for transit effects
Safety & Side Effects
已报告的副作用
- ⚠ Mild gas and bloating during initial use
- ⚠ Occasional abdominal discomfort
- ⚠ Rare loose stools
- ⚠ Very rare: bacteremia in immunocompromised individuals
已知相互作用
- ● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
- ● Immunosuppressants (use with caution in immunocompromised patients)
可耐受最高摄入量： Well-tolerated up to 17.2 billion CFU/day in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Bifidobacterium lactis help with Chronic Constipation?
Based on 4 studies with 600 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Chronic Constipation management. Our evidence grade is B (Good Evidence).
How much Bifidobacterium lactis should I take for Chronic Constipation?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bifidobacterium lactis?
Reported side effects may include Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bifidobacterium lactis and Chronic Constipation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Chronic Constipation
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