Bovine Colostrum 用于 急性腹泻
D 研究 目前仅存在初步研究（实验室研究、病例报告）。Some evidence for E. coli-specific diarrhea reduction with hyperimmune colostrum. Standard colostrum evidence is weaker.
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D
结论
Some evidence for E. coli-specific diarrhea reduction with hyperimmune colostrum. Standard colostrum evidence is weaker.
Key Study Findings
Randomized Controlled Trial
n=70
Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A …
Dose: None
vs: Placebo
Outcome: Diarrhea outcomes
效果: None
p=0.05
研究人群: None
Other
n=9
Milk diets influence doxorubicin-induced intestinal toxicity in piglets.
Dose: 100 mg
vs: None
Outcome: None
效果: None
P < 0.05
研究人群: men
Randomized Controlled Trial
n=90
Double-blind
Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused …
Dose: 400 mg
vs: placebo
Outcome: diarrhea
效果: None
p = 0.0005
研究人群: healthy adults
Other
n=605
12 weeks
Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study.
Dose: None
vs: None
Outcome: Pedimune in recurrent respiratory infection and diarrhoea--the Indian …
效果: None
None
研究人群: Children 1-8 yrs with recurrent URTI or diarrhea (India)
Key Statistics
2
研究数量
150
受试者
↑
Positive
D
等级
Referenced Papers
Nutrition (Burbank, Los …
2019
37 次引用
American journal of …
2016
15 次引用
Scandinavian journal of …
2011
77 次引用
Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study.
Other
Indian journal of …
2006
41 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 10-20 g/day
- travelersdiarrhea:
- Hyperimmune colostrum: 400-3,600 mg/day (anti-ETEC formulation)
- exercisegutprotection:
- 20 g/day starting 14 days before intense exercise
- intestinalpermeability:
- 20-60 g/day for gut barrier support
上限： No established upper limit; most studies use 10-60 g/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | 70 |
| 100 mg | -- | Positive | 9 |
| 400 mg | -- | Positive | 90 |
| None | 12 weeks | Positive | 605 |
最佳服用时间： On an empty stomach (30 minutes before meals) for gut barrier support
Safety & Side Effects
已报告的副作用
- ⚠ Mild GI discomfort (bloating, nausea) during initial use
- ⚠ Not suitable for individuals with cow's milk protein allergy
- ⚠ Lactose content may affect lactose-intolerant individuals
- ⚠ Potential concern about growth factor (IGF-1) content in cancer survivors (theoretical)
已知相互作用
- ● Immunosuppressants (colostrum immunoglobulins may theoretically interfere; clinical significance unclear)
- ● No significant adverse drug interactions established
可耐受最高摄入量： No established upper limit; most studies use 10-60 g/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Bovine Colostrum help with 急性腹泻?
Based on 2 studies with 150 participants, there is preliminary evidence that needs more research that Bovine Colostrum may support 急性腹泻 management. Our evidence grade is D (Very Early Research).
How much Bovine Colostrum should I take for 急性腹泻?
Studies have used various dosages. A commonly studied range is 10-20 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bovine Colostrum?
Reported side effects may include Mild GI discomfort (bloating, nausea) during initial use, Not suitable for individuals with cow's milk protein allergy, Lactose content may affect lactose-intolerant individuals, Potential concern about growth factor (IGF-1) content in cancer survivors (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bovine Colostrum and 急性腹泻?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 急性腹泻
Bovine Colostrum 用于其他健康状况
References
- [1] Ghazaleh Eslamian et al.. Nutrition. 2019. Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study. doi:10.1016/j.nut.2018.10.013 PubMed
- [2] Rene L Shen et al.. Am J Physiol Gastrointest Liver Physiol. 2016. Milk diets influence doxorubicin-induced intestinal toxicity in piglets. doi:10.1152/ajpgi.00373.2015 PubMed
- [3] Wlodzimierz Otto et al.. Scand J Gastroenterol. 2011. Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in … doi:10.3109/00365521.2011.574726 PubMed
- [4] Kamlesh Patel et al.. Indian J Pediatr. 2006. Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study. doi:10.1007/BF02759923 PubMed
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