Zinc 用于 急性腹泻
A 证据 多项大型临床试验一致显示出显著的益处。世界卫生组织/联合国儿童基金会建议所有急性腹泻儿童补充锌（20毫克/日，持续10至14天）。可将病程缩短约25%，并在随后2至3个月内减少腹泻复发。
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A
结论
世界卫生组织/联合国儿童基金会建议所有急性腹泻儿童补充锌（20毫克/日，持续10至14天）。可将病程缩短约25%，并在随后2至3个月内减少腹泻复发。
Key Study Findings
Review
The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries
Other
Clinical practice guidelines for acute infectious diarrhea in children in China (2024).
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Clinical practice guidelines for pediatric acute diarrhea
Randomized Controlled Trial
Open-label
Mobile phone call reminders to improve oral rehydration salt and zinc adherence for acute diarrhea …
Dose: ORS and zinc tablets
vs: Standard care (no reminders)
Outcome: ORS and zinc adherence rates
效果: None
None
研究人群: Children <5 with acute diarrhea
Review
Lactose intolerance: myths and facts. An update.
Dose: None
vs: None
Outcome: Lactose digestion and tolerance management
效果: None
None
研究人群: Lactose intolerant individuals
Randomized Controlled Trial
n=454
1 weeks
Double-blind
Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration …
Dose: 2 billion spores/5mL BID x 5 days
vs: Placebo + ORT + zinc
Outcome: Duration of acute diarrhea
效果: Median 42.83h vs 42.13h (HR 0.93, 95%CI 0.77-1.13)
p=0.70
研究人群: Children 6mo-5y with acute moderate diarrhea in India
Key Statistics
33
研究数量
10000
受试者
↑
Positive
A
等级
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 8-11 mg/day (RDA for adults)
- infantdiarrhea:
- 10 mg/day for 10-14 days (WHO recommendation for infants <6 months)
- pediatricdiarrhea:
- 20 mg/day for 10-14 days (WHO recommendation for children >6 months)
- gutbarriersupport:
- 15-30 mg/day elemental zinc
上限： 40 mg/day elemental zinc for adults (risk of copper depletion above this level)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| ORS and zinc tablets | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| 2 billion spores/5mL BID x 5 days | 1 weeks | Neutral | 454 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： With food to reduce nausea; space from antibiotics and iron by 2 hours
Safety & Side Effects
已报告的副作用
- ⚠ Nausea and vomiting (most common, especially on empty stomach)
- ⚠ Metallic taste
- ⚠ Copper depletion with long-term supplementation above 40 mg/day
- ⚠ Diarrhea (paradoxically, at high doses)
已知相互作用
- ● Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
- ● Penicillamine (zinc reduces absorption; space 2 hours)
- ● Iron supplements (mutual inhibition of absorption; take at different times)
- ● Copper supplements (zinc competes with copper for absorption)
可耐受最高摄入量： 40 mg/day elemental zinc for adults (risk of copper depletion above this level)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Zinc help with 急性腹泻?
Based on 33 studies with 10,000 participants, there is strong evidence from multiple clinical trials that Zinc may support 急性腹泻 management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for 急性腹泻?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (most common, especially on empty stomach), Metallic taste, Copper depletion with long-term supplementation above 40 mg/day, Diarrhea (paradoxically, at high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and 急性腹泻?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 急性腹泻
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