N-Acetyl Cysteine (NAC) cho Helicobacter pylori Infection
C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.
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C
Kết luận
NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.
Key Study Findings
In Vitro
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.
Dose: MIC 11 μg/mL
so với: None
Outcome: anti-Helicobacter pylori activity
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Other
Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: Published erratum (correction notice)
Review
Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Other
Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.
Dose: None
so với: None
Outcome: Cancer outcomes
Hiệu quả: None
None
Đối tượng nghiên cứu: Cancer patients
In Vitro
Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.
Dose: None
so với: None
Outcome: choline levels/cognition
Hiệu quả: None
None
Đối tượng nghiên cứu: Mice
Other
α-Lipoic Acid Inhibits Apoptosis by Suppressing the Loss of Ku Proteins in Helicobacter pylori-Infected Human …
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Key Statistics
3
Nghiên cứu
250
Người tham gia
↑
Positive
C
Xếp hạng
Referenced Papers
mLife
2026
Biochimica et biophysica …
2025
1 trích dẫn
Oxidative medicine and …
2025
Pharmaceutics
2024
8 trích dẫn
Frontiers in cellular …
2023
7 trích dẫn
Frontiers in cardiovascular …
2022
27 trích dẫn
Nutrients
2022
11 trích dẫn
Microbial drug resistance …
2020
34 trích dẫn
Therapeutic advances in …
2020
7 trích dẫn
Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori.
Other
Molecules (Basel, Switzerland)
2020
Expert review of …
2019
85 trích dẫn
The Cochrane database …
2019
21 trích dẫn
Oxidative medicine and …
2018
93 trích dẫn
The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis.
Meta-Analysis
Helicobacter
2018
18 trích dẫn
N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection.
Other
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2017
16 trích dẫn
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2016
101 trích dẫn
Helicobacter
2016
60 trích dẫn
Nutrition research (New …
2016
25 trích dẫn
Molecular carcinogenesis
2016
18 trích dẫn
Gut and liver
2016
17 trích dẫn
Pathogens and disease
2015
64 trích dẫn
World journal of …
2015
21 trích dẫn
Journal of cancer …
2013
10 trích dẫn
Alimentary pharmacology & …
2012
104 trích dẫn
Clinical and experimental …
2012
1 trích dẫn
Journal of clinical …
2011
34 trích dẫn
Clinical gastroenterology and …
2010
103 trích dẫn
Pharmaceutical biology
2010
16 trích dẫn
Probiotics and antimicrobial …
2010
9 trích dẫn
American family physician
2009
Helicobacter
2007
130 trích dẫn
World journal of …
2007
77 trích dẫn
Journal of agricultural …
2007
44 trích dẫn
American journal of …
2007
11 trích dẫn
Digestive diseases and …
2004
53 trích dẫn
Digestive diseases and …
2004
4 trích dẫn
Digestive diseases and …
2003
69 trích dẫn
Annals of the …
2002
30 trích dẫn
Journal of environmental …
2002
Pharmacological research
2001
25 trích dẫn
Schweizerische medizinische Wochenschrift
1994
22 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 600-1,200 mg/day in divided doses
- hpyloriadjunct:
- 600 mg twice daily alongside standard triple therapy
- antioxidantsupport:
- 600-900 mg/day
Giới hạn trên: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| MIC 11 μg/mL | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
Thời điểm dùng tốt nhất: With or without food; divide doses throughout the day
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Nausea and vomiting (most common, especially at higher doses)
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/odor
- ⚠ Headache
Tương tác đã biết
- ● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
- ● Activated charcoal (may reduce NAC absorption)
- ● Anticoagulants (NAC may have mild antiplatelet effects)
- ● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)
Mức hấp thụ tối đa cho phép: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?
Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Helicobacter pylori Infection
N-Acetyl Cysteine (NAC) cho các tình trạng khác
References
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