N-Acetyl Cysteine (NAC) 用于 Helicobacter pylori Infection

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'ingredient\u003Dn\u002Dacetyl\u002Dcysteine\u0026condition\u003Dh\u002Dpylori'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

结论

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

Key Study Findings

In Vitro

Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.

Dose: MIC 11 μg/mL vs: None Outcome: anti-Helicobacter pylori activity 效果: None None

研究人群: None

Other

Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Published erratum (correction notice)

Review

Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Other

Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.

Dose: None vs: None Outcome: Cancer outcomes 效果: None None

研究人群: Cancer patients

In Vitro

Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.

Dose: None vs: None Outcome: choline levels/cognition 效果: None None

研究人群: Mice

Other

α-Lipoic Acid Inhibits Apoptosis by Suppressing the Loss of Ku Proteins in Helicobacter pylori-Infected Human …

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Key Statistics

研究数量

250

受试者

↑

Positive

等级

Referenced Papers

Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity. Other

mLife 2026

Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis. Review

Biochimica et biophysica … 2025 1 次引用

Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter pylori Infection". Other

Oxidative medicine and … 2025

Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy. Other

Pharmaceutics 2024 8 次引用

Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production. Other

Frontiers in cellular … 2023 7 次引用

CagA+ Helicobacter pylori, Not CagA- Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation. Other

Frontiers in cardiovascular … 2022 27 次引用

α-Lipoic Acid Inhibits Apoptosis by Suppressing the Loss of Ku Proteins in Helicobacter pylori-Infected Human Gastric Epithelial Cells. Other

Nutrients 2022 11 次引用

Activity of Sodium Lauryl Sulfate, Rhamnolipids, and N-Acetylcysteine Against Biofilms of Five Common Pathogens. Other

Microbial drug resistance … 2020 34 次引用

Comparison of the effect of clarithromycin triple therapy with or without N-acetylcysteine in the eradication of Helicobacter pylori: a randomized … Other

Therapeutic advances in … 2020 7 次引用

Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori. Other

Molecules (Basel, Switzerland) 2020

Multidrug resistance in Helicobacter pylori: current state and future directions. Review

Expert review of … 2019 85 次引用

N-acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication. Meta-Analysis

The Cochrane database … 2019 21 次引用

N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter pylori Infection. Other

Oxidative medicine and … 2018 93 次引用

The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis. Meta-Analysis

Helicobacter 2018 18 次引用

N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection. Other

Journal of microbiology … 2017 16 次引用

Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. Other

Cell host & … 2016 101 次引用

Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species. Other

Helicobacter 2016 60 次引用

Supplementation with Angelica keiskei inhibits expression of inflammatory mediators in the gastric mucosa of Helicobacter pylori-infected mice. Other

Nutrition research (New … 2016 25 次引用

Helicobacter pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3β in human gastric cancer cells. Other

Molecular carcinogenesis 2016 18 次引用

Effects of N-acetylcysteine on First-Line Sequential Therapy for Helicobacter pylori Infection: A Randomized Controlled Pilot Trial. RCT

Gut and liver 2016 17 次引用

Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling … Other

Pathogens and disease 2015 64 次引用

Current Helicobacter pylori treatment in 2014. Review

World journal of … 2015 21 次引用

Oxidative DNA Damage Response in Helicobacter pylori-Infected Mongolian Gerbils. Other

Journal of cancer … 2013 10 次引用

Review article: biofilm formation by Helicobacter pylori as a target for eradication of resistant infection. Review

Alimentary pharmacology & … 2012 104 次引用

Update on triple therapy for eradication of Helicobacter pylori: current status of the art. Other

Clinical and experimental … 2012 1 次引用

The potential role of N-acetylcysteine for the treatment of Helicobacter pylori. Other

Journal of clinical … 2011 34 次引用

Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacter pylori: a clinical trial. RCT

Clinical gastroenterology and … 2010 103 次引用

Chios mastic, a natural supplement for zinc to enhance male sexuality and prostate function. Other

Pharmaceutical biology 2010 16 次引用

Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori. Other

Probiotics and antimicrobial … 2010 9 次引用

N-acetylcysteine: multiple clinical applications. Review

American family physician 2009

A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure? CCT

Helicobacter 2007 130 次引用

Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: an endoscopist-blinded, prospective, randomized study. RCT

World journal of … 2007 77 次引用

Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. Other

Journal of agricultural … 2007 44 次引用

Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands. Other

American journal of … 2007 11 次引用

N-acetylcysteine, a novel treatment for Helicobacter pylori infection. Other

Digestive diseases and … 2004 53 次引用

Cellular mucosal defense is attenuated with chronicity of Helicobacter pylori infection. Other

Digestive diseases and … 2004 4 次引用

Role of NF-kappaB and AP-1 on Helicobater pylori-induced IL-8 expression in AGS cells. Other

Digestive diseases and … 2003 69 次引用

Transcriptional regulation by thiol compounds in Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells. Other

Annals of the … 2002 30 次引用

Oxidant-sensitive transcription factor and cyclooxygenase-2 by Helicobacter pylori stimulation in human gastric cancer cells. Other

Journal of environmental … 2002

The antioxidant effect of rebamipide on oxygen free radical production by H. pylori-activated human neutrophils: in comparison with N-acetylcysteine, ascorbic … Other

Pharmacological research 2001 25 次引用

[Omeprazole/amoxicillin: improved eradication of Helicobacter pylori in smokers because of N-acetylcysteine]. RCT

Schweizerische medizinische Wochenschrift 1994 22 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 600-1,200 mg/day in divided doses
hpyloriadjunct:: 600 mg twice daily alongside standard triple therapy
antioxidantsupport:: 600-900 mg/day

上限： Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

研究中使用的剂量

剂量	持续时间	效果	N
MIC 11 μg/mL	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Negative	--
None	--	Positive	--

最佳服用时间： With or without food; divide doses throughout the day

Safety & Side Effects

已报告的副作用

⚠ Nausea and vomiting (most common, especially at higher doses)
⚠ Diarrhea
⚠ Unpleasant sulfur taste/odor
⚠ Headache

已知相互作用

● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
● Activated charcoal (may reduce NAC absorption)
● Anticoagulants (NAC may have mild antiplatelet effects)
● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)

可耐受最高摄入量： Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?

Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).

How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine (NAC)?

Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Helicobacter pylori Infection

Lactobacillus gasseri B

N-Acetyl Cysteine (NAC) 用于其他健康状况

Inflammatory Bowel Disease (IBD) — General D

快速结论

NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.

Evidence Strength52%

Moderate confidence

研究分析

RCT (4)Meta (2)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Helicobacter pylori Infection

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。