N-Acetyl Cysteine (NAC) para Helicobacter pylori Infection
C Evidencia Evidencia limitada de estudios pequeños, pero existen algunas señales positivas.NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.
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C
Conclusión
NAC (600-1,200 mg/day) may improve H. pylori eradication rates by disrupting biofilm. Small studies show improved eradication when combined with standard therapy.
Key Study Findings
In Vitro
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity.
Dose: MIC 11 μg/mL
vs: None
Outcome: anti-Helicobacter pylori activity
Efecto: None
None
Población: None
Other
Correction to "N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Published erratum (correction notice)
Review
Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Other
Liposomal Drug Delivery against Helicobacter pylori Using Furazolidone and N-Acetyl Cysteine in Augmented Therapy.
Dose: None
vs: None
Outcome: Cancer outcomes
Efecto: None
None
Población: Cancer patients
In Vitro
Helicobacter pylori infection selectively attenuates endothelial function in male mice via exosomes-mediated ROS production.
Dose: None
vs: None
Outcome: choline levels/cognition
Efecto: None
None
Población: Mice
Other
α-Lipoic Acid Inhibits Apoptosis by Suppressing the Loss of Ku Proteins in Helicobacter pylori-Infected Human …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Key Statistics
3
Estudios
250
Participantes
↑
Positive
C
Calificación
Referenced Papers
mLife
2026
Biochimica et biophysica …
2025
1 citas
Oxidative medicine and …
2025
Pharmaceutics
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8 citas
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27 citas
Nutrients
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34 citas
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Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori.
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2019
85 citas
The Cochrane database …
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Oxidative medicine and …
2018
93 citas
The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis.
Meta-Analysis
Helicobacter
2018
18 citas
N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection.
Other
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101 citas
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60 citas
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25 citas
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17 citas
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2015
64 citas
World journal of …
2015
21 citas
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10 citas
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2012
104 citas
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2012
1 citas
Journal of clinical …
2011
34 citas
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2010
103 citas
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2010
16 citas
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2010
9 citas
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2009
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2007
130 citas
World journal of …
2007
77 citas
Journal of agricultural …
2007
44 citas
American journal of …
2007
11 citas
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2004
53 citas
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2004
4 citas
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2003
69 citas
Annals of the …
2002
30 citas
Journal of environmental …
2002
Pharmacological research
2001
25 citas
Schweizerische medizinische Wochenschrift
1994
22 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 600-1,200 mg/day in divided doses
- hpyloriadjunct:
- 600 mg twice daily alongside standard triple therapy
- antioxidantsupport:
- 600-900 mg/day
Límite superior: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| MIC 11 μg/mL | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
Mejor momento para tomar: With or without food; divide doses throughout the day
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Nausea and vomiting (most common, especially at higher doses)
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/odor
- ⚠ Headache
Interacciones conocidas
- ● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
- ● Activated charcoal (may reduce NAC absorption)
- ● Anticoagulants (NAC may have mild antiplatelet effects)
- ● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)
Ingesta máxima tolerable: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does N-Acetyl Cysteine (NAC) help with Helicobacter pylori Infection?
Based on 3 studies with 250 participants, there is limited but promising evidence that N-Acetyl Cysteine (NAC) may support Helicobacter pylori Infection management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine (NAC) should I take for Helicobacter pylori Infection?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine (NAC)?
Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine (NAC) and Helicobacter pylori Infection?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Helicobacter pylori Infection
N-Acetyl Cysteine (NAC) para otras condiciones
References
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